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You searched for: Subject "glucagon-like peptides" Remove constraint Subject: "glucagon-like peptides" Journal Analytical biochemistry Remove constraint Journal: Analytical biochemistry Subject tandem mass spectrometry Remove constraint Subject: tandem mass spectrometry
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1. Simultaneous quantification of intracellular and secreted active and inactive glucagon-like peptide-1 from cultured cells

Author:
Amao, Michiko; Kitahara, Yoshiro; Tokunaga, Ayaka; Shimbo, Kazutaka; Eto, Yuzuru; Yamada, Naoyuki
Source:
Analytical biochemistry 2015 v.472 pp. 45-51
ISSN:
0003-2697
Subject:
glucagon-like peptide 1,   etc   ; cultured cells; glucose; hormone secretion; liquid chromatography; monitoring; noninsulin-dependent diabetes mellitus; patients; secretin; sucralose; tandem mass spectrometry;     Show all 11 Subjects
Abstract:
... Glucagon-like peptide-1 (GLP-1) is an incretin peptide that regulates islet hormone secretion. During recent years, incretin-based therapies have been widely used for patients with type 2 diabetes. GLP-1 peptides undergo N- and C-terminal processing for gain or loss of functions. We developed a method to quantify picomolar quantities of intact GLP-1 peptides using liquid chromatography–tandem mass ...
DOI:
10.1016/j.ab.2014.11.009