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- Mattson, Mark P., et al. Show all 9 Authors
- Analytical biochemistry 2019 v.572 pp. 1-8
- NAD (coenzyme); NADP (coenzyme); autoxidation; cell culture; cerebrospinal fluid; erythrocytes; humans; liquid chromatography; mass spectrometry; metabolites; metabolome; skeletal muscle
- ... The reduction-oxidation state of NAD+/NADH is critical for cellular health with NAD+ and its metabolites playing critical roles in aging and pathologies. Given the inherent autooxidation of reduced dinucleotides (i.e. NADH/NADPH), and the well-established differential stability, the accurate measurement of NAD+ and its metabolites is technically challenging. Moreover, sample processing, normalizat ...