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- Kafader, Jared O.; Melani, Rafael D.; Senko, Michael W.; Makarov, Alexander A.; Kelleher, Neil L.; Compton, Philip D.
- Analytical chemistry 2019 v.91 no.4 pp. 2776-2783
- antibodies; carbonate dehydratase; ions; molecular weight; proteins; signal-to-noise ratio
- ... It is well-known that with Orbitrap-based Fourier-transform-mass-spectrometry (FT-MS) analysis, longer-time-domain signals are needed to better resolve species of interest. Unfortunately, increasing the signal-acquisition period comes at the expense of increasing ion decay, which lowers signal-to-noise ratios and ultimately limits resolution. This is especially problematic for intact proteins, inc ...