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- Yang, Ke; Li, Jun; Zhao, Jiuzhou; Ren, Pengfei; Wang, Zhizhong; Wei, Bing; Dong, Bing; Sun, Rui; Wang, Xiaoyan; Groen, Harry J. M.; Ma, Jie; Guo, Yongjun
- Analytical chemistry 2018 v.90 no.19 pp. 11203-11209
- DNA; alleles; detection limit; disease course; droplets; drugs; enzyme inhibitors; epidermal growth factor receptors; high-throughput nucleotide sequencing; lung neoplasms; monitoring; mutation; patients; polymerase chain reaction; therapeutics
- ... A T790M secondary mutation in epidermal-growth-factor receptor (EGFR) is the most well-established EGFR-tyrosine-kinase-inhibitor (TKI) resistance marker in non-small-cell lung cancer (NSCLC). The current methods to rapidly and accurately detect T790M in clinical practice are not satisfactory because of several obstacles, including the unavailability of tumor-tissue rebiopsies and the low DNA copy ...