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- Chen, Hauh-Jyun Candy; Wang, Yi-Ching; Lin, Wen-Peng
- Analytical chemistry 2012 v.84 no.5 pp. 2521-2527
- DNA adducts; biomarkers; detection limit; humans; ionization; isotope dilution technique; leukocytes; monitoring; neoplasms; nucleotides; risk assessment; risk factors; smoking (habit); stable isotopes; tandem mass spectrometry; thymidine; tissues; urine
- ... Studies showed that levels of ethylated DNA adducts in certain tissues and urine are higher in smokers than in nonsmokers. Because cigarette smoking is a major risk factor of various cancers, DNA ethylation might play an important role in cigarette smoke-induced cancer formation. Among the ethylated DNA adducts, O²-ethylthymidine (O²-edT) and O⁴-ethylthymidine (O⁴-edT) are poorly repaired and are ...