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- Li, Yujian; Ding, Xiaojuan; Li, Dandan; Wu, Haiping; Huang, Wei; Ding, Shijia
- Analytical methods 2019 v.11 no.12 pp. 1613-1619
- DNA; analytical methods; catalytic activity; detection limit; fluorescence; fluorescent dyes; genes; humans; models; neoplasms
- ... In this study, an enzyme-free and homogeneous fluorescent biosensing strategy is described for the detection of DNA based on an entropy-driven strand displacement reaction (ESDR) and DNAzyme. In the presence of target DNA, toehold-mediated strand displacement results in the circulation of target DNA and release of DNAzyme sequences from the three-stranded complex. Upon cyclic amplification, one ta ...