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- Lu, Na; Zhang, Bin; Cheng, Likun; Wang, Jinshui; Zhang, Songlin; Fu, Shijun; Xiao, Yueqiang; Liu, Hongyan
- Annals of microbiology 2017 v.67 no.8 pp. 567-576
- process control, etc ; Escherichia coli; acetates; biomass production; byproducts; dissolved oxygen; fermentation; genes; genetic engineering; glucose; industrialization; metabolites; mutants; pH; phosphates; tryptophan; Show all 16 Subjects
- ... Acetate is a primary inhibitory metabolite in cultures of Escherichia coli, and the production of both biomass and desired products are increased by reducing the accumulation of acetate. In this study, the accumulation of acetate during ʟ-tryptophan production was decreased by genetic modification of ʟ-tryptophan-producing strain (BCTRP) and optimization of the fermentation process. The mutant (BC ...