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- Cao, Jay J.; Gregoire, Brian R.; Sun, Li; Song, Sihong
- Annals of the New York Academy of Sciences 2012 v.1240 pp. 1
- acid phosphatase; anti-inflammatory activity; blood serum; bone marrow; bone resorption; calcitonin; cytokines; estrogens; leptin; mice; osteocalcin; osteoclasts; ovariectomy; phosphates; receptors; tibia; tissue weight; trypsin inhibitors; uterus
- ... Proinflammatory cytokines are primary mediators of bone loss in estrogen deficiency. This study determined whether alpha-1 antitrypsin (AAT), a multifunctional protein with proteinase inhibitor and anti-inflammatory activities, mitigates bone loss induced by estrogen deficiency. Mice were either sham-operated or ovariectomized and injected with either AAT or phosphate buffered saline (PBS). Ovarie ...