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You searched for: Journal name Antioxidants Remove constraint Journal name: Antioxidants Publication year rev 7980-2020 Remove constraint Publication year rev: 7980-2020 Source 2020 v.9 no.12 Remove constraint Source: 2020 v.9 no.12
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1. The Antinociceptive, Antioxidant and Anti-Inflammatory Effects of 5-Fluoro-2-Oxindole during Inflammatory Pain

Author:
Alejandro Redondo; Gabriela Riego; Olga Pol
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
adjuvants; administrative management; analgesic effect; anti-inflammatory activity; antioxidants; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; inflammation; males; mice; mor; morphine; oxidative stress; pain; plasticity; protein content; protoporphyrin; quinones; receptors; somatosensory disorders; spinal cord; tin
Abstract:
... Recent studies demonstrate that 5-fluoro-2-oxindole inhibits neuropathic pain but the antinociceptive actions of this drug and its effects on the plasticity, oxidative and inflammatory changes induced by peripheral inflammation as well as on the effects and expression of µ-opioid receptors (MOR) have not been evaluated. In C57BL/6 male mice with inflammatory pain provoked by the subplantar adminis ...
DOI:
10.3390/antiox9121249

2. Antioxidant Supplementation Modulates Neutrophil Inflammatory Response to Exercise-Induced Stress

Author:
Lucrecia Carrera-Quintanar; Lorena Funes; María Herranz-López; Pascual Martínez-Peinado; Sandra Pascual-García; José M Sempere; Marina Boix-Castejón; Alfredo Córdova; Antoni Pons; Vicente Micol; Enrique Roche
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
Aloysia citrodora; almonds; antioxidant activity; antioxidant enzymes; ascorbic acid; beverages; blood sampling; creatine kinase; exercise; homogenization; inflammation; muscles; myeloperoxidase; myoglobin; neutrophils
Abstract:
... The aim of the present report was to evaluate the inflammatory response to a 2000-m running test considering neutrophil myeloperoxidase as an inflammatory marker, and to verify if supplements rich in antioxidants could modulate Post-test antioxidant and anti-inflammatory responses. To this end, a 21-day homogenization period was carried out with three groups: a control group, a supplemented group ...
DOI:
10.3390/antiox9121242

3. Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Author:
Shokoh Parham; Anousheh Zargar Kharazi; Hamid Reza Bakhsheshi-Rad; Hadi Nur; Ahmad Fauzi Ismail; Safian Sharif; Seeram RamaKrishna; Filippo Berto
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
Arctium lappa; Eryngium; Eucalyptus; Melissa officinalis; Mentha pulegium; Portulaca; Tribulus; adverse effects; antibiotics; antineoplastic agents; antioxidant activity; antioxidants; antiviral agents; antiviral properties; bacteria; biocompatible materials; chamomile; cinnamon; cloves; cytotoxicity; fennel; garlic; ginger; health services; heart diseases; herbal medicines; hygiene; lead; mint; nanosilver; oxidative stress; paper; population; thyme; tissue repair; turmeric; viruses
Abstract:
... Recently, increasing public concern about hygiene has been driving many studies to investigate antimicrobial and antiviral agents. However, the use of any antimicrobial agents must be limited due to their possible toxic or harmful effects. In recent years, due to previous antibiotics’ lesser side effects, the use of herbal materials instead of synthetic or chemical drugs is increasing. Herbal mate ...
DOI:
10.3390/antiox9121309

4. Association of Antioxidants Use with All-Cause and Cause-Specific Mortality: A Prospective Study of the UK Biobank

Author:
Inken Behrendt; Gerrit Eichner; Mathias Fasshauer
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
age; antioxidants; ascorbic acid; confidence interval; models; mortality; population; prospective studies; respiratory tract diseases; risk; selenium; testing; vitamin E; zinc
Abstract:
... Prospective studies and randomized controlled trials elucidating the impact of antioxidants supplementation on mortality risk are inconclusive. The present analysis determined association between regular antioxidants use and all-cause (primary objective), as well as cause-specific, mortality in 345,626 participants of the UK Biobank cohort using Cox proportional hazard models. All models were adju ...
DOI:
10.3390/antiox9121287

5. Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

Author:
Leon G. Martens; Jiao Luo; Fleur L. Meulmeester; Nadia Ashrafi; Esther Winters van Eekelen; Renée de Mutsert; Dennis O. Mook-Kanamori; Frits R. Rosendaal; Ko Willems van Dijk; Kevin Mills; Raymond Noordam; Diana van Heemst
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
age; alpha-tocopherol; antioxidant activity; blood serum; cross-sectional studies; dose response; epidemiology; hydroquinone; information; lifestyle; lipid peroxidation; lipids; liquid chromatography; men; metabolism; metabolites; obesity; oxidation; physical activity; population; questionnaires; reactive oxygen species; regression analysis; sleep; tandem mass spectrometry; Netherlands
Abstract:
... The antioxidant vitamin E (α-tocopherol, α-TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with vitamin E metabolism marked by urinary α-tocopheronolactone hydroquinone (α-TLHQ) and α-carboxymethyl-hydroxychroman (α-CEHC levels), as potential reflection of lipid oxidation. We conducted a cross-sectional study in the Netherlands Epide ...
DOI:
10.3390/antiox9121280

6. Berberis microphylla G. Forst (Calafate) Berry Extract Reduces Oxidative Stress and Lipid Peroxidation of Human LDL

Author:
Lia Olivares-Caro; Claudia Radojkovic; Si Yen Chau; Daniela Nova; Luis Bustamante; Jose Yamil Neira; Andy J. Perez; Claudia Mardones
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
Berberis microphylla; X-radiation; cardioprotective effect; cardiovascular diseases; diodes; fatty acid composition; fluorescence; gas chromatography-mass spectrometry; human umbilical vein endothelial cells; humans; incidence; linoleic acid; lipid peroxidation; low density lipoprotein; malondialdehyde; metals; models; oxidation; oxidative stress; phenolic compounds; reactive oxygen species
Abstract:
... Calafate (Berberis microphylla G. Forst) is a Patagonian barberry very rich in phenolic compounds. Our aim was to demonstrate, through in vitro models, that a comprehensive characterized calafate extract has a protective role against oxidative processes associated to cardiovascular disease development. Fifty-three phenolic compounds (17 of them not previously reported in calafate), were tentativel ...
DOI:
10.3390/antiox9121171

7. Biological Effects of Scattered Versus Scanned Proton Beams on Normal Tissues in Total Body Irradiated Mice: Survival, Genotoxicity, Oxidative Stress and Inflammation

Author:
Samia Chaouni; Alexandre Leduc; Frédéric Pouzoulet; Ludovic De Marzi; Frédérique Megnin-Chanet; Dinu Stefan; Jean-Louis Habrand; François Sichel; Carine Laurent
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
adverse effects; animal models; antioxidants; biomarkers; catalase; dosage; erythrocytes; frequency; genotoxicity; glutathione; glutathione peroxidase; heart; inflammation; irradiation; lipid peroxidation; lungs; mice; oxidative stress; plateaus; superoxide dismutase; tissues
Abstract:
... Side effects of proton therapy are poorly studied. Moreover, the differences in the method of dose delivery on normal tissues are not taken into account when proton beams are scanned instead of being scattered. We proposed here to study the effects of both modalities of proton beam delivery on blood; skin; lung and heart in a murine model. In that purpose; C57BL/6 mice were total body irradiated b ...
DOI:
10.3390/antiox9121170

8. L- Carnitine in Drosophila: A Review

Author:
Maria Rosaria Carillo; Carla Bertapelle; Filippo Scialò; Mario Siervo; Gianrico Spagnuolo; Michele Simeone; Gianfranco Peluso; Filomena Anna Digilio
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
Drosophila; acyl coenzyme A; antioxidants; biosynthesis; carnitine; energy; fatty acid metabolism; genes; homeostasis; humans; knowledge; mitochondria; models; mutants; neurodegenerative diseases; neuroglia; occurrence; therapeutics
Abstract:
... L-Carnitine is an amino acid derivative that plays a key role in the metabolism of fatty acids, including the shuttling of long-chain fatty acyl CoA to fuel mitochondrial β-oxidation. In addition, L-carnitine reduces oxidative damage and plays an essential role in the maintenance of cellular energy homeostasis. L-carnitine also plays an essential role in the control of cerebral functions, and the ...
DOI:
10.3390/antiox9121310

9. Carotenoids, Vitamin C, and Antioxidant Capacity in the Peel of Mandarin Fruit in Relation to the Susceptibility to Chilling Injury during Postharvest Cold Storage

Author:
Florencia Rey; Lorenzo Zacarías; María J. Rodrigo
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
Citrus; antioxidant activity; ascorbic acid; assays; chilling injury; citrus peels; cold storage; correlation; cultivars; fruits; postharvest diseases; protective effect; singlet oxygen; temperature; violaxanthin
Abstract:
... Chilling injury (CI) is a postharvest disorder occurring in the fruit of cold-sensitive Citrus species during storage at low temperatures. This study investigated the involvement of carotenoids and vitamin C, two major antioxidants of citrus peel, and the antioxidant capacity in the CI susceptibility of mandarin fruit. To that end, the fruit of three commercial varieties, Fortune, Nova, and Nadorc ...
DOI:
10.3390/antiox9121296

10. Chemical Profiling, Antioxidant, Cytotoxic Activities and Molecular Docking Simulation of Carrichtera annua DC. (Cruciferae)

Author:
Enas E. Eltamany; Sameh S. Elhady; Haidy A. Ahmed; Jihan M. Badr; Ahmad O. Noor; Safwat A. Ahmed; Mohamed S. Nafie
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
Brassicaceae; antioxidant activity; antioxidants; apoptosis; ascorbic acid; breasts; cell cycle checkpoints; chemical composition; computer simulation; cytotoxicity; extracts; flavonoids; hepatocytes; human cell lines; humans; liver; polyphenols; research; toxicity testing
Abstract:
... Our investigation intended to analyze the chemical composition and the antioxidant activity of Carrichtera annua and to evaluate the antiproliferative effect of C. annua crude and phenolics extracts by MTT assay on a panel of cancerous and non-cancerous breast and liver cell lines. The total flavonoid and phenolic contents of C. annua were 47.3 ± 17.9 mg RE/g and 83.8 ± 5.3 mg respectively. C. ann ...
DOI:
10.3390/antiox9121286

11. Comprehensive Analysis of Antioxidant Compounds from Lippia citriodora and Hibiscus sabdariffa Green Extracts Attained by Response Surface Methodology

Author:
María del Carmen Villegas-Aguilar; Francisco Javier Leyva-Jiménez; María de la Luz Cádiz-Gurrea; Antonio Segura-Carretero; David Arráez-Román
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
Aloysia citrodora; Hibiscus sabdariffa; antioxidant activity; antioxidants; assays; calyx; ethanol; extraction; extracts; functional foods; industry; leaves; phenolic compounds; phytochemicals; polar compounds; response surface methodology; temperature; value-added products
Abstract:
... Phenolic compounds have shown to have a high bioactive potential against various pathologies, postulating as an interesting alternative to manage some diseases. In this sense, both Lippia citriodora and Hibiscus sabdariffa are two botanical sources with a demonstrated high bioactive potential, in which their antioxidant capacity stands out. In this work, the optimization of the extraction conditio ...
DOI:
10.3390/antiox9121175

12. Differential Sex-Dependent Regulation of the Alveolar Macrophage miRNome of SP-A2 and co-ex (SP-A1/SP-A2) and Sex Differences Attenuation after 18 h of Ozone Exposure

Author:
Nithyananda Thorenoor; David S. Phelps; Joanna Floros
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
air; antioxidants; females; gender differences; gene expression; genes; genetic variation; genetically modified organisms; genotype; humans; macrophages; males; methodology; mice; microRNA; ozone
Abstract:
... Background: Human SP-A1 and SP-A2, encoded by SFTPA1 and SFTPA2, and their genetic variants differentially impact alveolar macrophage (AM) functions and regulation, including the miRNome. We investigated whether miRNome differences previously observed between AM from SP-A2 and SP-A1/SP-A2 mice are due to continued qualitative differences or a delayed response of mice carrying a single gene. Method ...
DOI:
10.3390/antiox9121190

13. Discovery of Spilanthol Endoperoxide as a Redox Natural Compound Active against Mammalian Prx3 and Chlamydiatrachomatis Infection

Author:
Rosine Dushime; Yunhuang Zhu; Hanzhi Wu; Daniel Saez; Kirtikar Shukla; Heather Brown-Harding; Maique W. Biavatti; Kimberly J. Nelson; Leslie B. Poole; William T. Lowther; Paul B. Jones; Cristina M. Furdui; Allen W. Tsang
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
Chlamydia trachomatis; actin; active ingredients; anti-inflammatory activity; antibiotics; antioxidants; assays; blindness; cytoskeleton; image analysis; infection; mammals; mitochondria; oxidation; pathogens; peroxidation; peroxiredoxin; uterine cervical neoplasms
Abstract:
... Chlamydia trachomatis (Ct) is a bacterial intracellular pathogen responsible for a plethora of diseases ranging from blindness to pelvic inflammatory diseases and cervical cancer. Although this disease is effectively treated with antibiotics, concerns for development of resistance prompt the need for new low-cost treatments. Here we report the activity of spilanthol (SPL), a natural compound with ...
DOI:
10.3390/antiox9121220

14. Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection?

Author:
Klaudia Čobanová; Zora Váradyová; Ľubomíra Grešáková; Katarína Kucková; Dominika Mravčáková; Marián Várady
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
Haemonchus contortus; antioxidant activity; antioxidant enzymes; blood serum; catalase; feed supplements; gastrointestinal nematodes; glutathione peroxidase; ileum; infection; intestinal mucosa; kidneys; lambs; lipid peroxidation; liver; medicinal plants; superoxide dismutase; zinc
Abstract:
... This study was conducted to evaluate the effect of feed supplementation with a medicinal herbs mixture (Hmix) and organic zinc (Zn), alone or in combination, on the antioxidant responses and mineral status of lambs infected with the gastrointestinal nematode parasite Haemonchus contortus. A total of 24 experimentally infected lambs were randomly allocated to 1 of 4 dietary treatments (n = 6). The ...
DOI:
10.3390/antiox9121172

15. Downregulation of the Glo1 Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats

Author:
Jan Šilhavý; Hana Malínská; Martina Hüttl; Irena Marková; Olena Oliyarnyk; Petr Mlejnek; Miroslava Šimáková; František Liška; Ludmila Kazdová; Radka Moravcová; Jiří Novotný; Michal Pravenec
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
adiposity; advanced glycation end products; age; antioxidants; blood serum; diabetes; enzymes; epididymis; genes; glucose; heart; heterozygosity; insulin; lipogenesis; liver; metabolites; obesity; rats; triacylglycerols; weight; white adipose tissue
Abstract:
... Methylglyoxal (MG), a potent precursor of advanced glycation end-products (AGE), is increased in metabolic disorders such as diabetes and obesity. MG and other dicarbonyl metabolites are detoxified by the glyoxalase system in which glyoxalase 1, coded by the Glo1 gene, serves as the rate-limiting enzyme. In this study, we analyzed the effects of Glo1 downregulation on glucose and lipid metabolism ...
DOI:
10.3390/antiox9121179

16. Effect of Heme Oxygenase-1 on Melanoma Development in Mice—Role of Tumor-Infiltrating Immune Cells

Author:
Halina Was; Tomasz Cichon; Ryszard Smolarczyk; Bozena Lackowska; Agnieszka Mazur-Bialy; Magdalena Mazur; Agata Szade; Pawel Dominik; Milena Mazan; Jerzy Kotlinowski; Anna Zebzda; Anna Kusienicka; Claudine Kieda; Jozef Dulak; Alicja Jozkowicz
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
angiogenesis; antioxidants; cell lines; females; genotype; heme oxygenase (biliverdin-producing); leukocytes; liver; lungs; males; melanoma; metastasis; methodology; mice; neoplasm progression; spleen
Abstract:
... Objective: Heme oxygenase-1 (HO-1) is a cytoprotective, proangiogenic and anti-inflammatory enzyme that is often upregulated in tumors. Overexpression of HO-1 in melanoma cells leads to enhanced tumor growth, augmented angiogenesis and resistance to anticancer treatment. The effect of HO-1 in host cells on tumor development is, however, hardly known. Methods and results: To clarify the effect of H ...
DOI:
10.3390/antiox9121223

17. Effects of Two-Week Betaine Supplementation on Apoptosis, Oxidative Stress, and Aerobic Capacity after Exhaustive Endurance Exercise

Author:
Ming-Ta Yang; Xiu-Xin Lee; Bo-Huei Huang; Li-Hui Chien; Chia-Chi Wang; Kuei-Hui Chan
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
antioxidants; apoptosis; betaine; blood sampling; decline; design; exercise; exercise test; heart rate; lymphocytes; males; membrane potential; mitochondria; oxidative stress; oxygen consumption; peak oxygen uptake; placebos; sports drinks; thiobarbituric acid-reactive substances
Abstract:
... This study evaluated the effects of 2 weeks of betaine supplementation on apoptosis, oxidative stress, and aerobic capacity after exhaustive endurance exercise (EEE). A double-blind, crossover, and counterbalanced design was adopted, with 10 healthy male participants asked to consume betaine (1.25 g of betaine mixed with 300 mL of sports beverage, twice per day for 2 weeks) or placebo (300 mL of s ...
DOI:
10.3390/antiox9121189

18. Ellagic Acid as a Tool to Limit the Diabetes Burden: Updated Evidence

Author:
Antonio J. Amor; Carmen Gómez-Guerrero; Emilio Ortega; Aleix Sala-Vila; Iolanda Lázaro
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
animal models; animal research; anti-inflammatory activity; antioxidants; biomedical research; diabetic complications; ellagic acid; extracts; fruits; glucose; glycation; glycemic control; humans; hydrolysis; inflammation; intestines; metabolites; noninsulin-dependent diabetes mellitus; oxidation; oxidative stress; pathogenesis; polyphenols; pomegranate juice; seeds; testing
Abstract:
... Oxidative stress contributes not only to the pathogenesis of type 2 diabetes (T2D) but also to diabetic vascular complications. It follows that antioxidants might contribute to limiting the diabetes burden. In this review we focus on ellagic acid (EA), a compound that can be obtained upon intestinal hydrolysis of dietary ellagitannins, a family of polyphenols naturally found in several fruits and ...
DOI:
10.3390/antiox9121226

19. Enhancement of Biological Properties of Blackcurrants by Lactic Acid Fermentation and Incorporation into Yogurt: A Review

Author:
Rebecca Kowalski; Erika Gustafson; Matthew Carroll; Elvira Gonzalez de Mejia
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
antioxidant activity; antioxidants; area; black currants; chemical composition; exercise; functional foods; humans; information; juices; lactic acid bacteria; lactic fermentation; literature; nervous system diseases; noninsulin-dependent diabetes mellitus; polyphenols; prebiotics; probiotics; research; yogurt
Abstract:
... Blackcurrants (BC) and yogurt are known to possess several health benefits. The objective of this review was to compile the latest information on the effect of lactic acid fermentation on BC and their incorporation into yogurt, including the impact of this combination on chemical composition, sensory aspects, and health attributes of the blend. Google Scholar, Scopus, and PubMed were used to resea ...
DOI:
10.3390/antiox9121194

20. Ethanol Induces Microglial Cell Death via the NOX/ROS/PARP/TRPM2 Signalling Pathway

Author:
Muhammad Syahreel Azhad Sha’fie; Sharani Rathakrishnan; Iffa Nadhira Hazanol; Mohd Haziq Izzazuddin Dali; Mohd Ezuan Khayat; Syahida Ahmad; Yazmin Hussin; Noorjahan Banu Alitheen; Lin-Hua Jiang; Sharifah Alawieyah Syed Mortadza
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
NAD(P)H oxidase (H2O2-forming); antioxidants; assays; brain; cell death; ethanol; fluorescence; image analysis; neuroglia; oxidative stress; propidium; protein kinase C; signal transduction
Abstract:
... Microglial cells are the primary immune cell resident in the brain. Growing evidence indicates that microglial cells play a prominent role in alcohol-induced brain pathologies. However, alcohol-induced effects on microglial cells and the underlying mechanisms are not fully understood, and evidence exists to support generation of oxidative stress due to NADPH oxidases (NOX_-mediated production of r ...
DOI:
10.3390/antiox9121253