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- Hayat, Akhtar; Barthelmebs, Lise; Marty, Jean-Louis
- Applied biochemistry and biotechnology 2012 v.166 no.1 pp. 47-56
- Dinophysis; Prorocentrum; colorimetry; detection limit; diarrhetic shellfish poisoning; enzyme activity; guanosine triphosphate; humans; okadaic acid; phosphoprotein phosphatase; polymers; silica; storage quality; toxins
- ... Okadaic acid (OA), a lipophilic toxin, is produced by Dinophysis and Prorocentrum, and causes diarrheic shellfish poisoning to humans. The mechanism of OA action is based on the reversible inhibition of protein phosphatase type 2A (PP2A) by the toxin. Therefore, this inhibition could be used to develop assay for OA detection. In this work, a colorimetric test based on the PP2A inhibition was devel ...
- Nakamura, Yukio; He, Xinjun; Kato, Hiroyuki; Wakitani, Shigeyuki; Kobayashi, Tatsuya; Watanabe, Sumiko; Iida, Atsumi; Tahara, Hideaki; Warman, Matthew L.; Watanapokasin, Ramida; Postlethwait, John H.
- Applied biochemistry and biotechnology 2012 v.166 no.1 pp. 64-71
- Danio rerio; cartilage; chondrocytes; humans; mutants; platelet-derived growth factor; receptors; small interfering RNA; transcription (genetics)
- ... MicroRNA-140 (miR-140) is specifically expressed in developing cartilage tissues. We have previously reported that miR-140 plays an important role during palatal cartilage development by modulating platelet-derived growth factor receptor alpha (pdgfra) in zebrafish. However, the regulatory mechanism of miR-140 in cartilage is still unknown. Using developing zebrafish, sox9a mutant (sox9a−/−) and s ...
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