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- Gagnaire, Beatrice; Gagné, François; André, Chantale; Blaise, Christian; Abbaci, Khedidja; Budzinski, Hélène; Dévier, Marie-Hélène; Garric, Jeanne
- Aquatic toxicology 2009 v.92 no.3 pp. 155-167
- Gastropoda; snails; endocrine-disrupting chemicals; biomarkers; abiotic stress; vitellogenin; proteins; gonads; histology; phosphates; lipids; animal reproduction; reproductive toxicology; France
- ... The occurrence in aquatic environments of compounds capable of acting as endocrine disruptors (ED) is of concern for wildlife. Elevated levels of the egg-yolk precursor protein vitellogenin (Vg) are widely accepted as a biomarker for xenoestrogen exposure in aquatic organisms. The purpose of this study was to develop a method for tracking changes in levels of Vg-like proteins in gastropods. Vg-lik ...
- Ankley, Gerald T.; Bencic, David C.; Breen, Michael S.; Collette, Timothy W.; Conolly, Rory B.; Denslow, Nancy D.; Edwards, Stephen W.; Ekman, Drew R.; Garcia-Reyero, Natalia; Jensen, Kathleen M.; Lazorchak, James M.; Martinović, Dalma; Miller, David H.; Perkins, Edward J.; Orlando, Edward F.; Villeneuve, Daniel L.; Wang, Rong-Lin; Watanabe, Karen H.
- Aquatic toxicology 2009 v.92 no.3 pp. 168-178
- endocrine-disrupting chemicals; fish; animal models; Pimephales promelas; minnows; Danio rerio; toxicity; mechanism of action; bioinformatics; genomics; metabolomics; transcriptomics; proteomics; prediction; models
- ... Knowledge of possible toxic mechanisms (or modes) of action (MOA) of chemicals can provide valuable insights as to appropriate methods for assessing exposure and effects, thereby reducing uncertainties related to extrapolation across species, endpoints and chemical structure. However, MOA-based testing seldom has been used for assessing the ecological risk of chemicals. This is in part because pas ...