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- Theilen, Nicholas T.; Jeremic, Nevena; Weber, Gregory J.; Tyagi, Suresh C.
- Archives of biochemistry and biophysics 2019 v.666 pp. 138-147
- animal models; antioxidants; body weight; exercise; gene overexpression; genes; males; mice; mitochondria; muscles; muscular atrophy; skeletal muscle; superoxide dismutase; therapeutics; transcription factors; transgenic animals
- ... The present study aims to investigate if overexpressing the mitochondrial transcription factor A (TFAM) gene in a transgenic mouse model diminishes soleus and gastrocnemius atrophy occurring during hindlimb suspension (HLS). Additionally, we aim to observe if combining exercise training in TFAM transgenic mice prior to HLS has a synergistic effect in preventing skeletal muscle atrophy. Male C57BL/ ...
- Soledad, Roman Barbara; Charles, Steenbergen; Samarjit, Das
- Archives of biochemistry and biophysics 2019 v.666 pp. 52-62
- adenosine triphosphate; cytosol; electron transport chain; genes; homeostasis; mitochondria; mitochondrial genome; mitochondrial membrane; nuclear-encoded proteins; transcription (genetics); transcription factors
- ... Over two thousand proteins are found in the mitochondrial compartment but the mitochondrial genome codes for only 13 proteins. The majority of mitochondrial proteins are products of nuclear genes and are synthesized in the cytosol, then translocated into the mitochondria. Most of the subunits of the five respiratory chain complexes in the inner mitochondrial membrane, which generate a proton gradi ...