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- Liu, Yu; Zhang, Lei; Shao, Xiao-Xia; Hu, Meng-Jun; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun
- Archives of biochemistry and biophysics 2016 v.604 pp. 113-120
- G-protein coupled receptors, etc ; agonists; aspartic acid; food intake; humans; insulin; mutants; neuropeptides; relaxin; stress response; Show all 10 Subjects
- ... Relaxin-3 is an insulin/relaxin superfamily neuropeptide involved in the regulation of food intake and stress response via activation of its cognate receptor RXFP3, an A-class G protein-coupled receptor (GPCR). In recent studies, a highly conserved ExxxD motif essential for binding of relaxin-3 has been identified at extracellular end of the second transmembrane domain (TMD2) of RXFP3. For most of ...
- Cattaneo, Fabio; Parisi, Melania; Fioretti, Tiziana; Sarnataro, Daniela; Esposito, Gabriella; Ammendola, Rosario
- Archives of biochemistry and biophysics 2016 v.603 pp. 10-19
- G-protein coupled receptors, etc ; Western blotting; agonists; fluorescent antibody technique; humans; models; mutagenesis; neoplasm cells; neoplasms; nuclear localization signals; phosphorylation; Show all 11 Subjects
- ... Current models of G protein-coupled receptors (GPCRs) signaling describe binding of external agonists to cell surface receptors which, in turn, trigger several biological responses. New paradigms indicate that GPCRs localize to and signal at the nucleus, thus regulating distinct signaling cascades. The formyl-peptide receptor FPR2 belongs to the GPCR super-family and is coupled to PTX-sensitive Gi ...