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1. A mass spectrometry approach for the identification and localization of small aldehyde modifications of proteins

Author:
Afonso, Catarina B.; Sousa, Bebiana C.; Pitt, Andrew R.; Spickett, Corinne M.
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 38-45
ISSN:
0003-9861
Subject:
acrolein; chemical bonding; cysteine; histidine; human serum albumin; ions; lysine; lysozyme; mass spectrometry; models; oxidation; polyunsaturated fatty acids; schiff bases
Abstract:
... Lipids containing polyunsaturated fatty acids are primary targets of oxidation, which produces reactive short-chain aldehydes that can covalently modify proteins, a process called lipoxidation. Improved mass spectrometry (MS) methods for the analysis of these adducts in complex biological systems are needed. Lysozyme and human serum albumin (HSA) were used as model proteins to investigate lipoxida ...
DOI:
10.1016/j.abb.2018.03.026

2. Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans

Author:
Castello, Fabio; Costabile, Giuseppina; Bresciani, Letizia; Tassotti, Michele; Naviglio, Daniele; Luongo, Delia; Ciciola, Paola; Vitale, Marilena; Vetrani, Claudia; Galaverna, Gianni; Brighenti, Furio; Giacco, Rosalba; Del Rio, Daniele; Mena, Pedro
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 1-9
ISSN:
0003-9861
Subject:
bioavailability; byproducts; catechin; grape pomace; humans; juice industry; metabolites; multivariate analysis; pharmacokinetics; phenolic acids; polyphenols; propionic acid; urine; wines
Abstract:
... Grape pomace, the major byproduct of the wine and juice industry, is a relevant source of bioactive phenolic compounds. However, polyphenol bioavailability in humans is not well understood, and the inter-individual variability in the production of phenolic metabolites has not been comprehensively assessed to date. The pharmacokinetic and excretive profiles of phenolic metabolites after the acute a ...
DOI:
10.1016/j.abb.2018.03.021

3. Biological and pharmacological effects of hexahydrocurcumin, a metabolite of curcumin

Author:
Huang, Yiyuan; Cao, Shijie; Zhang, Qiang; Zhang, Hongyang; Fan, Yuqi; Qiu, Feng; Kang, Ning
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 31-37
ISSN:
0003-9861
Subject:
antioxidants; bioavailability; curcumin; human diseases; in vivo studies; medicinal properties; metabolism; metabolites
Abstract:
... Curcumin, one of the most precious pharmacologically relevant natural products, has gained considerable attention among scientists for decades because of its multi-pharmacological activities in the clinical. However, critical studies on its pharmacological and toxicological activities are needed to understand how this compound can have these biological functions considering its poor oral bioavaila ...
DOI:
10.1016/j.abb.2018.03.030

4. Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation

Author:
Bathish, Boushra; Turner, Rufus; Paumann-Page, Martina; Kettle, Anthony J.; Winterbourn, Christine C.
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 120-127
ISSN:
0003-9861
Subject:
acetaminophen; bromides; catalase; collagen; crosslinking; enzyme activity; enzyme inhibitors; epithelial cells; extracellular matrix; hydrazides; hydrogen peroxide; hydroxylysine; mass spectrometry; methionine; myeloperoxidase; oxidation; peroxidase; thiocyanates
Abstract:
... Peroxidasin is a heme peroxidase that catalyses the oxidation of bromide by hydrogen peroxide to form an essential sulfilimine cross-link between methionine and hydroxylysine residues in collagen IV. We investigated cross-linking by peroxidasin embedded in extracellular matrix isolated from cultured epithelial cells and its sensitivity to alternative substrates and peroxidase inhibitors. Peroxidas ...
DOI:
10.1016/j.abb.2018.03.038

5. Cholesterol modulates the binding properties of human relaxin family peptide receptor 3 with its ligands

Author:
Wang, Jia-Hui; Hu, Meng-Jun; Shao, Xiao-Xia; Wei, Dian; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 24-30
ISSN:
0003-9861
Subject:
G-protein coupled receptors; agonists; antagonists; binding capacity; cholesterol; food intake; humans; kidneys; ligands; peptide receptors; plasma membrane; relaxin; stress response
Abstract:
... Relaxin family peptide receptor 3 (RXFP3) is implicated in the regulation of food intake and stress response upon activation by its cognate agonist relaxin-3. As an A-class G protein-coupled receptor, RXFP3 is an integral plasma membrane protein with seven transmembrane domains, yet influence of the membrane lipids on its function remains unknown. In the present study, we disclosed that cholestero ...
DOI:
10.1016/j.abb.2018.03.031

6. Comparison of different analytical techniques for the analysis of carotenoids in tamarillo (Solanum betaceum Cav.)

Author:
Giuffrida, Daniele; Zoccali, Mariosimone; Arigò, Adriana; Cacciola, Francesco; Roa, Coralia Osorio; Dugo, Paola; Mondello, Luigi
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 161-167
ISSN:
0003-9861
Subject:
Solanum betaceum; antheraxanthin; esters; liquids; mass spectrometry; supercritical fluid extraction
Abstract:
... An on-line method based on the coupling of supercritical fluid extraction and supercritical fluid chromatography with triple quadrupole mass spectrometry detection (SFE-SFC-QqQ/MS) for the native carotenoids characterization and apocarotenoids detection in yellow tamarillo was developed for the first time; this is the first work reporting the application of this methodology for the apocarotenoids ...
DOI:
10.1016/j.abb.2018.03.011

7. Effects of grape consumption on biomarkers of inflammation, endothelial function, and PBMC gene expression in obese subjects

Author:
Bardagjy, Allison S.; Hu, Qian; Giebler, Kathryn A.; Ford, Addison; Steinberg, Francene M.
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 145-152
ISSN:
0003-9861
Subject:
adults; biomarkers; carbohydrates; cell adhesion molecules; cross-over studies; endothelins; freeze drying; fruit consumption; gene expression; grapes; inflammation; mononuclear leukocytes; normal values; obesity; oxidative stress
Abstract:
... This study investigated effects of grape consumption on biomarkers of cardiovascular health in obese participants in both postprandial and chronic settings. Twenty obese adults participated in this randomized, placebo controlled, double-blinded crossover trial. Participants were randomized to consume 60 g freeze-dried polyphenol-rich whole grape powder (GP) or placebo (PBO) followed by high fat hi ...
DOI:
10.1016/j.abb.2018.04.003

8. (-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells

Author:
Cremonini, Eleonora; Oteiza, Patricia I.
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 55-63
ISSN:
0003-9861
Subject:
NAD(P)H oxidase (H2O2-forming); Western diets; animal models; carbohydrates; enzyme activity; enzyme inhibitors; human cell lines; humans; insulin; insulin resistance; lipids; liver; metabolites; mice; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; oxidative stress; palmitates; risk; vegetables
Abstract:
... While diets rich in fruit and vegetables can decrease the risk for type 2 diabetes (T2D), diets rich in fat and carbohydrates can increase it. The flavanol-3-ol (-)-epicatechin (EC) can improve insulin sensitivity both in humans and animal models of T2D. NADPH oxidases and oxidative stress can contribute to the development of insulin resistance. This study investigated the capacity of EC and EC me ...
DOI:
10.1016/j.abb.2018.03.027

9. Excited-state dynamics of 3,3′-dihydroxyisorenieratene and (3R,3′R)-zeaxanthin: Observation of vibrationally hot S0 species

Author:
Ehlers, Florian; Scholz, Mirko; Oum, Kawon; Lenzer, Thomas
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 137-144
ISSN:
0003-9861
Subject:
absorption; beta-ionone; bleaching agents; cooling; solvents; wavelengths; zeaxanthin
Abstract:
... We report on an ultrafast transient absorption study of all-trans-3,3′-dihydroxyisorenieratene (“DHIR”) and all-trans-(3R,3′R)-zeaxanthin in organic solvents covering the wavelength range 350–770 nm. The lifetime of the S2 state in both carotenoids is 160–170 fs. Upon internal conversion (IC) non-equilibrated S1 molecules are formed which internally relax on a 300–400 fs time scale. The time const ...
DOI:
10.1016/j.abb.2018.03.035

10. Histone acetyltransferase 1 up regulates Bcl2L12 expression in nasopharyngeal cancer cells

Author:
Miao, Bei-Ping; Zhang, Rui-Shi; Yang, Gui; Sun, Jin-Jie; Tang, Yu-Yan; Liang, Wei-Feng; Liu, Tao; Wen, Zhong; Yang, Ping-Chang; Nie, Guo-Hui
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 72-79
ISSN:
0003-9861
Subject:
Western blotting; absorption; apoptosis; flow cytometry; gene expression; histone acetyltransferase; histones; humans; neoplasm cells; neoplasms; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; screening; therapeutics; transcription (genetics)
Abstract:
... The deregulation of Bcl2L12 expression in cancer has been recognized, but the causative factors are unknown. Histone acetyltransferases (HAT) play critical roles in the regulation gene transcription. This study tests a hypothesis that the aberrant activities of HAT induce deregulation of Bcl2L12 in nasopharyngeal cancer (NPC). In this study, human NPC tissues were collected from the clinic. The ex ...
DOI:
10.1016/j.abb.2018.03.040

11. Inhibition of anthrax lethal factor by ssDNA aptamers

Author:
Lahousse, Mieke; Park, Hae-Chul; Lee, Sang-Choon; Ha, Na-Reum; Jung, In-Pil; Schlesinger, Sara R.; Shackelford, Kaylin; Yoon, Moon-Young; Kim, Sung-Kun
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 16-23
ISSN:
0003-9861
Subject:
Bacillus anthracis; anthrax; anthrax toxin; bacteria; binding capacity; biomarkers; bovine serum albumin; cell viability; cross reaction; diagnostic techniques; enzyme activity; inhibitory concentration 50; mitogen-activated protein kinase kinase; neutralization; oligonucleotides; secretion; single-stranded DNA; toxicity; virulence
Abstract:
... Anthrax is caused by Bacillus anthracis, a bacterium that is able to secrete the toxins protective antigen, edema factor and lethal factor. Due to the high level of secretion from the bacteria and its severe virulence, lethal factor (LF) has been sought as a biomarker for detecting bacterial infection and as an effective target to neutralize toxicity. In this study, we found three aptamers, and bi ...
DOI:
10.1016/j.abb.2018.03.028

12. Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species

Author:
Coker, Melanie S.; Forbes, Louisa V.; Plowman-Holmes, Matthew; Murdoch, David R.; Winterbourn, Christine C.; Kettle, Anthony J.
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 80-89
ISSN:
0003-9861
Subject:
Gram-negative bacteria; Staphylococcus aureus; carotenoids; chlorine; enterobactin; enzyme inhibitors; hydrogen peroxide; myeloperoxidase; neutrophils; oxidants; pathogens; phagosomes; siderophores; toxicity; virulence
Abstract:
... When neutrophils engulf bacteria, myeloperoxidase converts hydrogen peroxide to hypochlorous acid, which is toxic to all micro-organisms. It has been suggested that some pathogens have virulence factors that target myeloperoxidase to dampen the oxidative reactions of neutrophils. These virulence factors include staphyloxanthin, the golden pigment of Staphylococcus aureus, and enterobactin – a side ...
DOI:
10.1016/j.abb.2018.03.039

13. Long noncoding RNA BDNF-AS is downregulated in cervical cancer and has anti-cancer functions by negatively associating with BDNF

Author:
Zhang, Huimin; Liu, Caihong; Yan, Ting; Wang, Jun; Liang, Wentong
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 113-119
ISSN:
0003-9861
Subject:
Lentivirus; antineoplastic activity; cell lines; gene expression; humans; non-coding RNA; quantitative polymerase chain reaction; uterine cervical neoplasms
Abstract:
... We investigated expression and mechanism long noncoding RNA BDNF-AS in human cervical cancer (CC).BDNF-AS expressions were examined by qPCR in CC cell lines and human CC tumors. CC cell lines, SiHa and DoTc2-4510 were transduced with lentivirus to ectopically overexpress BDNF-AS. Possible anti-cancer effects of BDNF overexpression were examined on CC in vitro proliferation and migration, and in vi ...
DOI:
10.1016/j.abb.2018.03.023

14. Long noncoding RNA SNHG6 promotes osteosarcoma cell proliferation through regulating p21 and KLF2

Author:
Ruan, Jianwei; Zheng, Longlong; Hu, Nan; Guan, Guoyi; Chen, Jialin; Zhou, Xiaozhong; Li, Maoquan
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 128-136
ISSN:
0003-9861
Subject:
apoptosis; carcinogenesis; cell cycle checkpoints; cell lines; cell proliferation; genes; in vitro studies; interphase; loss-of-function mutation; mice; non-coding RNA; osteosarcoma; patients; quantitative polymerase chain reaction; regression analysis; reverse transcriptase polymerase chain reaction; survival rate
Abstract:
... The effects of long non-coding RNAs (lncRNAs) on cellular biological processes and even the tumorigenesis have been widely reported. Small nucleolar RNA host gene 6 (SNHG6) has been reported to participate in regulating biological behaviors of multiple types of cancers. Nevertheless, the functions of SNHG6 in osteosarcoma still remain to be uncovered. This study intended to determine the clinical ...
DOI:
10.1016/j.abb.2018.03.036

15. Metabolic changes in urine and serum during progression of diabetic kidney disease in a mouse model

Author:
Kim, Nan Hee; Hyeon, Jin Seong; Kim, Nam Hoon; Cho, Ahreum; Lee, Gayoung; Jang, Seo Young; Kim, Mi-Kyung; Lee, Eun Young; Chung, Choon Hee; Ha, Hunjoo; Hwang, Geum Sook
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 90-97
ISSN:
0003-9861
Subject:
albumins; animal models; biomarkers; blood serum; early diagnosis; excretion; fatty acid metabolism; glucose; kidney diseases; metabolites; metabolomics; mice; nuclear magnetic resonance spectroscopy; pathophysiology; tricarboxylic acid cycle; urine
Abstract:
... Diabetic kidney disease (DKD) involves various pathogenic processes during progression to end stage renal disease, and activated metabolic pathways might be changing based on major pathophysiologic mechanisms as DKD progresses. In this study, nuclear magnetic resonance spectroscopy (NMR)-based metabolic profiling was performed in db/db mice to suggest potential biomarkers for early detection and i ...
DOI:
10.1016/j.abb.2018.03.042

16. Optical assessment of skin carotenoid status as a biomarker of vegetable and fruit intake

Author:
Ermakov, Igor V.; Ermakova, Maia; Sharifzadeh, Mohsen; Gorusupudi, Aruna; Farnsworth, Kelliann; Bernstein, Paul S.; Stookey, Jodi; Evans, Jane; Arana, Tito; Tao-Lew, Lisa; Isman, Carly; Clayton, Anna; Obana, Akira; Whigham, Leah; Redelfs, Alisha H.; Jahns, Lisa; Gellermann, Werner
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 46-54
ISSN:
0003-9861
Subject:
Hispanics; Raman spectroscopy; adults; biomarkers; blood serum; carotenoids; children; day care centers; ethnic differences; fruit consumption; high performance liquid chromatography; melanin; men; nutritional intervention; ophthalmology; screening; skin (animal); tobacco; vegetables; women
Abstract:
... Resonance Raman spectroscopy (RRS) and reflection spectroscopy (RS) are optical methods applicable to the non-invasive detection of carotenoids in human skin. RRS is the older, more thoroughly validated method, whereas RS is newer and has several advantages. Since collective skin carotenoid levels serve as a biomarker for vegetable and fruit intake, both methods hold promise as convenient screenin ...
Handle:
10113/5929379
DOI:
10.1016/j.abb.2018.03.033

17. Plasma proteins associated with circulating carotenoids in Nepalese school-aged children

Author:
Eroglu, Abdulkerim; Schulze, Kerry J.; Yager, James; Cole, Robert N.; Christian, Parul; Nonyane, Bareng A.S.; Lee, Sun Eun; Wu, Lee S.F.; Khatry, Subarna; Groopman, John; West, Keith P.
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 153-160
ISSN:
0003-9861
Subject:
alpha-carotene; anti-inflammatory agents; antioxidant activity; antioxidants; beta-carotene; beta-cryptoxanthin; biomarkers; blood proteins; chromatography; fruit consumption; lipids; lutein; lycopene; models; nutrition assessment; proteomics; school children; tandem mass spectrometry; vegetables; vitamin A; zeaxanthin; Nepal
Abstract:
... Carotenoids are naturally occurring pigments that function as vitamin A precursors, antioxidants, anti-inflammatory agents or biomarkers of recent vegetable and fruit intake, and are thus important for population health and nutritional assessment. An assay approach that measures proteins could be more technologically feasible than chromatography, thus enabling more frequent carotenoid status asses ...
DOI:
10.1016/j.abb.2018.03.025
PubMed:
29605494
PubMed Central:
PMC5937903

18. Research trends in flavonoids and health

Author:
Perez-Vizcaino, Francisco; Fraga, Cesar G.
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 107-112
ISSN:
0003-9861
Subject:
anthocyanidins; coronary disease; epidemiological studies; flavanols; flavonols; food composition; fruits; functional foods; healthy diet; human health; ingredients; isoflavones; medicinal plants; neoplasms; polyphenols; resveratrol; stroke; vegetables
Abstract:
... Herein we describe, based on some bibliometric data, how the field of research on flavonoids has evolved over the last 25 years. The number of papers on flavonoids has risen in an exponential manner over these years, much faster than other fields on food constituents. This increase appears to be related to the contemporary explosion of interest in healthy foods, supplements and nutraceuticals. It ...
DOI:
10.1016/j.abb.2018.03.022

19. Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes

Author:
Mitani, Takakazu; Takaya, Tomohide; Harada, Naoki; Katayama, Shigeru; Yamaji, Ryoichi; Nakamura, Soichiro; Ashida, Hitoshi
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 98-106
ISSN:
0003-9861
Subject:
adipocytes; adipokines; adipose tissue; anti-inflammatory activity; binding proteins; blood glucose; corticosterone; dexamethasone; diet; gene expression; glucocorticoid receptors; hyperglycemia; inflammation; insulin resistance; interleukin-6; messenger RNA; mice; secretion; theophylline; transcription (genetics)
Abstract:
... Adipose tissues in obese individuals are characterized by a state of chronic low-grade inflammation. Pre-adipocytes and adipocytes in this state secrete pro-inflammatory adipokines, such as interleukin 6 (IL-6), which induce insulin resistance and hyperglycemia. Theophylline (1,3-dimethylxanthine) exerts anti-inflammatory effects, but its effects on pro-inflammatory adipokine secretion by pre-adip ...
DOI:
10.1016/j.abb.2018.04.001

20. Tubeimoside V sensitizes human triple negative breast cancer MDA-MB-231 cells to anoikis via regulating caveolin-1-related signaling pathways

Author:
Wang, Ke; Zhu, Xue; Chen, Yu; Yin, Yongxiang; Ma, Tao
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 10-15
ISSN:
0003-9861
Subject:
breast neoplasms; desmosides; drug therapy; ethanol; humans; metastasis; neoplasm cells; programmed cell death; signal transduction; tubers
Abstract:
... Metastatic triple-negative breast cancer (TNBC) has poor outcome with conventional chemotherapy regimens due to its aggressive behavior. The acquisition of anoikis resistance, a programmed cell death process triggered by substratum detachment, is an important mechanism in TNBC metastasis. Therefore, agents that can restore the sensitivity of cancer cells to anoikis may be helpful for the treatment ...
DOI:
10.1016/j.abb.2018.03.029