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- Fordwour, Osei Boakye; Wolthers, Kirsten R.
- Archives of biochemistry and biophysics 2018 v.654 pp. 85-96
- Acinetobacter; NADP (coenzyme); active sites; catalytic activity; cyclohexanones; esters; hydrogen bonding; lactones; models; nicotinamide; oxygen; phosphates; reducing agents; ribose; spectral analysis
- ... Baeyer-Villiger monooxygenases are flavoenzymes that use NADPH and O2 to convert ketones to esters or lactones. A diagnostic feature of BVMO catalysis is the dual role of the pyridine nucleotide: NADPH functions as a reductant of the FAD cofactor and the resulting NADP+ acts to stabilize the ensuing C4a-peroxyflavin intermediate. Using cyclohexanone monooxygenase from Acinetobacter sp. NCIMB 9871 ...