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- Park, Seongjoon; Sung, Bokyung; Jang, Eun Ji; Kim, Dae Hyun; Park, Chan Hum; Choi, Yeon Ja; Ha, Young Mi; Kim, Mi Kyung; Kim, Nam Deuk; Yu, Byung Pal; Chung, Hae Young
- Archives of pharmacal research 2013 v.36 no.7 pp. 880-889
- IKappaB kinase; anti-inflammatory activity; anti-inflammatory agents; antioxidants; arachidonic acid; endothelial cells; gene expression; inducible nitric oxide synthase; mitogen-activated protein kinase; oxidants; oxidative stress; phosphorylation; prostaglandin synthase; rats; transcription factor NF-kappa B
- ... In the present study, the anti-inflammatory effect of salicylideneamino-2-thiophenol (SAL-2), a derivative of salicylate, on a potent oxidant 4-hydroxynonenal (HNE)-induced oxidative stress was investigated using rat prostate endothelial (YPEN-1) cells. We focused on anti-inflammatory activity of SAL-2 which was determined by its ability to suppress COX-2 and iNOS gene expression through suppressi ...