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- Liang, Qiaoli; Yu, Fang; Cui, Xiaodong; Duan, Jin’ao; Wu, Qinan; Nagarkatti, Prakash; Fan, Daping
- Archives of pharmacal research 2013 v.36 no.7 pp. 890-896
- Scirpus; Toll-like receptor 2; Toll-like receptor 4; adhesion; anti-inflammatory activity; cardiovascular diseases; cell adhesion; chemokine CCL2; human umbilical vein endothelial cells; inflammation; interleukins; lipopolysaccharides; macrophages; medicinal plants; monocytes; phosphorylation; translation (genetics); tubers
- ... Sparstolonin B (SsnB) is an isocoumarin compound isolated from the tubers of both Sparganium stoloniferum and Scirpus yagara. We previously demonstrated that SsnB blocked the Toll-like receptor (TLR) 2- and TLR4-triggered inflammatory signaling in macrophages by inhibiting the recruitment of MyD88 to the TIR domains of TLR2 and TLR4. The present study was designed to examine the effects of SsnB on ...
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