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- Bae, Eun Ju
- Archives of pharmacal research 2017 v.40 no.12 pp. 1380-1389
- adiposity; animal models; chromatin; genomics; gluconeogenesis; glucose tolerance; glucose transporters; glycolysis; homeostasis; insulin secretion; longevity; mammals; neoplasms; noninsulin-dependent diabetes mellitus; obesity; pathophysiology; skeletal muscle; triacylglycerols
- ... Sirtuin 6 (SIRT6), one of the seven members of mammalian sirtuin family, localizes in the nucleus and primarily regulates chromatin signaling and genomic integrity. Recent studies established the critical role of SIRT6 in the pathophysiology of metabolic disease, as well as its roles in longevity and cancer. These roles that were determined by genetic studies include promoting pancreatic insulin s ...