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- Choi, Yoon Kyung
- Archives of pharmacal research 2017 v.40 no.12 pp. 1433-1442
- astrocytes; blood vessels; endothelial cells; epithelium; gene expression; glucose transporters; humans; hypoxia; hypoxia-inducible factor 1; messenger RNA; precipitin tests; protein kinase C; protein synthesis; retina; secretion; small interfering RNA; transfection; vascular endothelial growth factor receptor-2; vascular endothelial growth factors
- ... Treatment of human retinal microvascular endothelial cells (HRMECs) with vascular endothelial growth factor 165 (VEGF₁₆₅) increased hypoxia-inducible factor 1α (HIF-1α), VEGF, and glucose transporter 1 (Glut-1) mRNA expression and Glut-1 protein localization to the membrane. In contrast, treatment of human retinal pigment epithelium cells with VEGF₁₆₅ did not induce HIF-1α, VEGF, and Glut-1 gene e ...