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- Matsuzaki, Keiichi, et al. Show all 7 Authors
- Archives of pharmacal research 2013 v.36 no.8 pp. 1029-1038
- DNA; DNA damage; DNA topoisomerase; Euphorbia kansui; Western blotting; apoptosis; caspase-3; cell cycle; cell proliferation; enzyme activity; enzyme inhibition; gene expression regulation; medicinal plants
- ... We have previously reported that many ingenol compounds derived from Euphorbia kansui exhibit topoisomerase (topo) II inhibitory activity. Of these compounds, 3EZ,20Ac-ingenol inhibited topo I activity. Camptothecin, which inhibits the religation activity of topo I without interfering with the binding of topo I to DNA and induces topo I-mediated DNA cleavage, was used as a positive control. In thi ...
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