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- Shirato, Kazuya; Maejima, Madoka; Hirai, Asuka; Ami, Yasushi; Takeyama, Natsumi; Tsuchiya, Kotaro; Kusanagi, Kouich; Nunoya, Tetsuo; Taguchi, Fumihiro
- Archives of virology 2010 v.155 no.12 pp. 1989-1995
- piglets, etc ; Porcine epidemic diarrhea virus; amino acid substitution; animal models; brain; cell fusion; cultured cells; diarrhea; giant cells; mice; suckling; virulence; viruses; Show all 13 Subjects
- ... Porcine epidemic diarrhea virus (PEDV) is the major causative agent of fatal diarrhea in piglets. To study the pathogenic features of PEDV using a mouse model, PEDV with virulence in mice is required. In pursuit of this, we adapted a tissue-culture-passed PEDV MK strain to suckling mouse brains. PEDV obtained after ten passages through the brains (MK-p10) had increased virulence for mice, and its ...