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- Betakova, Tatiana; Hay, Alan J.
- Archives of virology 2009 v.154 no.10 pp. 1619-1624
- histidine, etc ; Influenza A virus; Influenza B virus; humans; ion channels; mutants; mutation; pH; toxicity; tryptophan; Show all 10 Subjects
- ... Co-expression of the BM2 protein with pH-sensitive HA reduces the conversion of HA to its low-pH conformation during transport to the cell surface in the same way as human M2 proteins. BM2 protein is capable of increasing vesicular pH by as much as 0.4 pH units. Mutation analysis showed that replacement of H19 in BM2 protein by A and L resulted in loss of activity, while M2, with the mutation H37A ...