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- Han, Min-Hee, et al. Show all 8 Authors
- Archives of virology 2014 v.159 no.10 pp. 2549-2557
- hepatitis; hepatoma; metalloproteinases; peroxisomes; reactive oxygen species
- ... HBx acts as a multifunctional regulator that modulates various cellular responses, which can lead to development and progression of hepatocellular carcinoma (HCC). Here, we show that the HBx protein is also localized to peroxisomes, and this increases cellular reactive oxygen species (ROS) to levels that are higher than when HBx is localized to other organelles. The elevated ROS strongly activated ...