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- Lynch, Sean M.; Frei, Balz; Morrow, Jason D.; Roberts, L. Jackson II; Xu, Aiming; Jackson, Terence; Reyna, Ronald; Klevay, Leslie M.; Vita, Joseph A.; Keaney, John F. Jr.
- Arteriosclerosis, thrombosis, and vascular biology 1997 v.17 no.11 pp. 2975
- superoxide dismutase; enzyme activity; copper; nutrient deficiencies; long term effects; lipid peroxidation; endothelium; aorta; vasodilation; rats
- ... Nitric oxide (NO) and superoxide are both constitutive products of the endothelium. Because NO is readily inactivated by superoxide, the bioactivity of endothelium-derived NO (EDNO) is dependent on local activity of superoxide dismutase (SOD). We examined the effects of chronic inhibition of copper-zinc SOD (CuZnSOD) using a rat model of dietary copper restriction. Male weanling Sprague-Dawley rat ...