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- Author:
- Olivier, Maryline; Bott, Romain; Frisdal, Eric; Nowicki, Marion; Plengpanich, Wanee; Desmarchelier, Charles; Roi, Stéphanie; Quinn, Carmel M.; Gelissen, Ingrid; Jessup, Wendy; Van Eck, Miranda; Guérin, Maryse; Le Goff, Wilfried; Reboul, Emmanuelle
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1741-1751
- ISSN:
- 1388-1981
- Subject:
- cholesterol; gamma-tocopherol; hepatocytes; humans; lipoproteins; liver; macrophages; mice; physiological transport; rats; tissues; transporters
- Abstract:
- ... Vitamin E membrane transport has been shown to involve the cholesterol transporters SR-BI, ABCA1 and NPC1L1. Our aim was to investigate the possible participation of another cholesterol transporter in cellular vitamin E efflux: ABCG1. In Abcg1-deficient mice, vitamin E concentration was reduced in plasma lipoproteins whereas most tissues displayed a higher vitamin E content compared to wild-type m ...
- DOI:
- 10.1016/j.bbalip.2014.10.003
-
http://dx.doi.org/10.1016/j.bbalip.2014.10.003
- Author:
- Rodriguez Sawicki, Luciana; Guerbi, María Ximena; Falomir Lockhart, Lisandro Jorge; Curto, Lucrecia María; Delfino, José María; Córsico, Betina; Franchini, Gisela Raquel
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1733-1740
- ISSN:
- 1388-1981
- Subject:
- artificial membranes; fatty acid-binding proteins; fatty acids; ligands; proteolysis
- Abstract:
- ... Intestinal fatty acid binding protein (IFABP) is an intracellular lipid binding protein whose specific functions within the cell are still uncertain. An abbreviated version of IFABP encompassing residues 29–126, dubbed Δ98Δ is a stable product of limited proteolysis with clostripain of holo-IFABP. Cumulative evidence shows that Δ98Δ adopts a stable, monomeric and functional fold, with compact core ...
- DOI:
- 10.1016/j.bbalip.2014.09.022
-
http://dx.doi.org/10.1016/j.bbalip.2014.09.022
- Author:
- Hansen, Ida R.; Jansson, Kim M.; Cannon, Barbara; Nedergaard, Jan
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1691-1699
- ISSN:
- 1388-1981
- Subject:
- acclimation; adipocytes; autocrine signaling; brown adipose tissue; cafeteria foods; cell culture; cold; epididymis; gene expression; gene expression regulation; high fat diet; males; mice; muscles; obesogenic diet; signal peptide; white adipose tissue
- Abstract:
- ... Based on results from a signal sequence trap, we investigated chemerin gene expression in brown adipose tissue. Male NMRI mice were exposed to 30, 22 or 4°C for 3weeks, or were fed control (chow) diet, cafeteria diet or high-fat diet at thermoneutrality for the same time. In brown adipose tissue, cold acclimation strongly diminished chemerin gene expression, whereas obesogenic diets augmented expr ...
- DOI:
- 10.1016/j.bbalip.2014.09.003
-
http://dx.doi.org/10.1016/j.bbalip.2014.09.003
- Author:
- Abdel Shakor, Abo Bakr; Atia, Mona; Ismail, Ismail Ahmed; Alshehri, Ali; El-Refaey, Hesham; Kwiatkowska, Katarzyna; Sobota, Andrzej
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1672-1682
- ISSN:
- 1388-1981
- Subject:
- P-glycoproteins; antineoplastic agents; apoptosis; caspase-3; cell viability; ceramides; curcumin; cyclosporine; genes; humans; leukemia; multiple drug resistance; neoplasm cells; sphingomyelins
- Abstract:
- ... Most anti-cancer agents induce apoptosis, however, a development of multidrug resistance in cancer cells and defects in apoptosis contribute often to treatment failure. Here, the mechanism of curcumin-induced apoptosis was investigated in human leukemia HL60 cells and their HL60/VCR multidrug-resistant counterparts. In both cell lines curcumin induced a bi-phasic ceramide generation with a slow ph ...
- DOI:
- 10.1016/j.bbalip.2014.09.006
-
http://dx.doi.org/10.1016/j.bbalip.2014.09.006
- Author:
- Mizuguchi, Chiharu; Hata, Mami; Dhanasekaran, Padmaja; Nickel, Margaret; Okuhira, Keiichiro; Phillips, Michael C.; Lund-Katz, Sissel; Saito, Hiroyuki
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1716-1724
- ISSN:
- 1388-1981
- Subject:
- apolipoprotein E; cholesterol metabolism; energy transfer; fluorescence; guanidines; humans; mutation; phosphatidylcholines
- Abstract:
- ... Human apolipoprotein E (apoE) isoforms exhibit different conformational stabilities and lipid-binding properties that give rise to altered cholesterol metabolism among the isoforms. Using Trp-substituted mutations and site-directed fluorescence labeling, we made a comprehensive comparison of the conformational organization of the N- and C-terminal domains and lipid interactions between the apoE3 a ...
- DOI:
- 10.1016/j.bbalip.2014.09.019
- PubMed:
- 25281910
- PubMed Central:
- PMC4342298
-
http://dx.doi.org/10.1016/j.bbalip.2014.09.019
- Author:
- Park, Woo-Jae; Park, Joo-Won; Merrill, Alfred H.; Storch, Judith; Pewzner-Jung, Yael; Futerman, Anthony H.
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1754-1766
- ISSN:
- 1388-1981
- Subject:
- hepatocytes; fatty acids; Dependoparvovirus; high fat diet; liver; proteins; weight gain; adipose tissue; skeletal muscle; triacylglycerols; mice; insulin; ceramides; sphingosine N-acyltransferase
- Abstract:
- ... Ceramide synthase 2 (CerS2) null mice cannot synthesize very-long acyl chain (C22–C24) ceramides resulting in significant alterations in the acyl chain composition of sphingolipids. We now demonstrate that hepatic triacylglycerol (TG) levels are reduced in the liver but not in the adipose tissue or skeletal muscle of the CerS2 null mouse, both before and after feeding with a high fat diet (HFD), w ...
- DOI:
- 10.1016/j.bbalip.2014.09.009
- PubMed:
- 25241943
- PubMed Central:
- PMC4406097
-
http://dx.doi.org/10.1016/j.bbalip.2014.09.009
- Author:
- Baumgartner, Werner; Weth, Agnes; Gutberlet, Judith; Harms, Gregory; Groschner, Klaus
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1725-1732
- ISSN:
- 1388-1981
- Subject:
- adherens junctions; adhesion; cadherins; cell adhesion; cell fractionation; cholesterol; endothelial cells; fluorescence microscopy; fractionation; microfilaments
- Abstract:
- ... VE-cadherin is the predominant adhesion molecule in vascular endothelial cells being responsible for maintenance of the endothelial barrier function by forming adhesive contacts (adherens junctions) to neighbouring cells. We found by use of single molecule fluorescence microscopy that VE-cadherin is localised in preformed clusters when not inside adherens junctions. These clusters depend on the in ...
- DOI:
- 10.1016/j.bbalip.2014.08.016
-
http://dx.doi.org/10.1016/j.bbalip.2014.08.016
- Author:
- Stieb, Stefanie; Roth, Ziv; Dal Magro, Christina; Fischer, Sabine; Butz, Eric; Sagi, Amir; Khalaila, Isam; Lieb, Bernhard; Schenk, Sven; Hoeger, Ulrich
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1700-1708
- ISSN:
- 1388-1981
- Subject:
- Astacus leptodactylus; Macrobrachium rosenbergii; amino acids; apolipoproteins; binding capacity; crayfish; hepatopancreas; high density lipoprotein; lipid transfer proteins; mass spectrometry; open reading frames; peptides; shrimp; transcriptome
- Abstract:
- ... The novel discoidal lipoprotein (dLp) recently detected in the crayfish, differs from other crustacean lipoproteins in its large size, apoprotein composition and high lipid binding capacity. We identified the dLp sequence by transcriptome analyses of the hepatopancreas and mass spectrometry. Further de novo assembly of the NGS data followed by BLAST searches using the sequence of the high density ...
- DOI:
- 10.1016/j.bbalip.2014.09.020
-
http://dx.doi.org/10.1016/j.bbalip.2014.09.020
- Author:
- Guijas, Carlos; Rodríguez, Juan P.; Rubio, Julio M.; Balboa, María A.; Balsinde, Jesús
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1661-1671
- ISSN:
- 1388-1981
- Subject:
- atherosclerosis; biogenesis; biosynthesis; carcinogenesis; cell physiology; diabetes; droplets; fatty acids; fatty liver; homeostasis; inflammation; leukocytes; neoplasms; neurodegenerative diseases; obesity; organelles; pathophysiology; phospholipase A2; phospholipids
- Abstract:
- ... The classical regard of lipid droplets as mere static energy-storage organelles has evolved dramatically. Nowadays these organelles are known to participate in key processes of cell homeostasis, and their abnormal regulation is linked to several disorders including metabolic diseases (diabetes, obesity, atherosclerosis or hepatic steatosis), inflammatory responses in leukocytes, cancer development ...
- DOI:
- 10.1016/j.bbalip.2014.10.004
-
http://dx.doi.org/10.1016/j.bbalip.2014.10.004
- Author:
- He, Lei; Qin, Shucun; Dang, Lin; Song, Guohua; Yao, Shutong; Yang, Nana; Li, Yuzhen
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1709-1715
- ISSN:
- 1388-1981
- Subject:
- C-reactive protein; anti-inflammatory activity; apoptosis; cardiovascular diseases; cell movement; correlation; cross-sectional studies; endothelial cells; high density lipoprotein cholesterol; hyperlipidemia; in vitro studies; interleukin-6; low density lipoprotein; malondialdehyde; monocytes; necrosis; oxidation; patients; psoriasis; tumor necrosis factor-alpha
- Abstract:
- ... Psoriasis is a chronic inflammatory skin disease, which has been linked to dyslipidemia with potential functional impairment of lipoproteins. This cross-sectional study was designed to characterize the biological activities of plasma lipoproteins in 25 patients with psoriasis and 25 age- and sex-matched healthy controls.In the present study, we found that plasma levels of high-density lipoprotein ...
- DOI:
- 10.1016/j.bbalip.2014.09.008
-
http://dx.doi.org/10.1016/j.bbalip.2014.09.008
- Author:
- Gregory, Melissa K.; James, Michael J.
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1656-1660
- ISSN:
- 1388-1981
- Subject:
- Oncorhynchus mykiss; alpha-linolenic acid; docosahexaenoic acid; docosapentaenoic acid; eicosapentaenoic acid; enzymes; fish; gene expression; liver; mammals; omega-3 fatty acids; yeasts
- Abstract:
- ... The synthesis of the omega-3 long-chain polyunsaturated fatty acids (LCPUFA) eicosapentaenoic acid (EPA; 20:5n−3) and docosahexaenoic acid (DHA; 22:6n−3) from dietary α-linolenic acid (ALA; 18:3n−3) requires three desaturation and three elongation steps in vertebrates. The elongation of EPA to docosapentaenoic acid (DPA; 22:5n−3) can be catalysed by the elongase enzymes Elovl5 or Elovl2, but furth ...
- DOI:
- 10.1016/j.bbalip.2014.10.001
-
http://dx.doi.org/10.1016/j.bbalip.2014.10.001
- Author:
- Bosma, Madeleen; Dapito, Dianne H.; Drosatos-Tampakaki, Zoi; Huiping-Son, Ni; Huang, Li-Shin; Kersten, Sander; Drosatos, Konstantinos; Goldberg, Ira J.
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1648-1655
- ISSN:
- 1388-1981
- Subject:
- cardiomyocytes; droplets; endoplasmic reticulum; free fatty acids; gene expression; humans; lipid metabolism; lipotoxicity; models; oleic acid; palmitates; phosphorylation; triacylglycerols
- Abstract:
- ... We used human cardiomyocyte-derived cells to create an in vitro model to study lipid metabolism and explored the effects of PPARγ, ACSL1 and ATGL on fatty acid-induced ER stress. Compared to oleate, palmitate treatment resulted in less intracellular accumulation of lipid droplets and more ER stress, as measured by upregulation of CHOP, ATF6 and GRP78 gene expression and phosphorylation of eukaryot ...
- DOI:
- 10.1016/j.bbalip.2014.09.012
- PubMed:
- 25251292
- PubMed Central:
- PMC4342292
-
http://dx.doi.org/10.1016/j.bbalip.2014.09.012
- Author:
- Xie, Ping; Zeng, Xu; Xiao, Jing; Sun, Bing; Yang, Dan
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1683-1690
- ISSN:
- 1388-1981
- Subject:
- aorta; atherosclerosis; blood serum; bone marrow; cholesterol metabolism; genes; high density lipoprotein cholesterol; homeostasis; interleukin-6; knockout mutants; macrophages; mice; phenotype; transgenic animals; triacylglycerol lipase; triacylglycerols; tumor necrosis factor-alpha
- Abstract:
- ... Comparative Gene Identification-58 (CGI-58), as an adipose triglyceride lipase (ATGL) activator, strongly increases ATGL-mediated triglyceride (TG) catabolism. Previous studies have shown that CGI-58 affects intestinal cholesterol homeostasis independently of ATGL activity. Therefore, we hypothesized that CGI-58 was involved in macrophage cholesterol metabolism and consequently atherosclerotic les ...
- DOI:
- 10.1016/j.bbalip.2014.08.014
-
http://dx.doi.org/10.1016/j.bbalip.2014.08.014
- Author:
- Patwardhan, Gauri A.; Hosain, Salman B.; Liu, David X.; Khiste, Sachin K.; Zhao, Yunfeng; Bielawski, Jacek; Jazwinski, S. Michal; Liu, Yong-Yu
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1571-1580
- ISSN:
- 1388-1981
- Subject:
- DNA; animal ovaries; apoptosis; bioactive properties; ceramides; epigenetics; genes; heterozygosity; messenger RNA; mutants; neoplasm cells; ovarian neoplasms; phosphoprotein phosphatase; proteins
- Abstract:
- ... Mutants of tumor suppressor p53 not only lose the activity in genome stabilizing and in tumor suppression, but also exhibit oncogenic function in cancer cells. Most efforts in restoring p53 biological activity focus on either altering mutant-protein conformation or introducing an exogenous p53 gene into cells to eliminate p53-mutant cancer cells. Being different from these, we report that ceramide ...
- DOI:
- 10.1016/j.bbalip.2014.08.017
- PubMed:
- 25195822
- PubMed Central:
- PMC4188706
-
http://dx.doi.org/10.1016/j.bbalip.2014.08.017
- Author:
- da Silva, Robin P.; Kelly, Karen B.; Leonard, Kelly-Ann; Jacobs, René L.
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1639-1646
- ISSN:
- 1388-1981
- Subject:
- beta oxidation; creatine; dose response; fatty liver; fibrosis; hepatocytes; hepatoma; high fat diet; lipid peroxidation; lipids; lipolysis; liver; messenger RNA; radiolabeling; rats; secretion; transcription (genetics)
- Abstract:
- ... Non-alcoholic fatty liver disease encompasses a wide spectrum of liver damage including steatosis, non-alcoholic steatohepatitis, fibrosis and cirrhosis. We have previously reported that creatine supplementation prevents hepatic steatosis and lipid peroxidation in rats fed a high-fat diet. In this study, we employed oleate-treated McArdle RH-7777 rat hepatoma cells to investigate the role of creat ...
- DOI:
- 10.1016/j.bbalip.2014.09.001
-
http://dx.doi.org/10.1016/j.bbalip.2014.09.001
- Author:
- Park, Miyoung; Choi, Yeon A; Lee, Hee Gu; Kim, Keun Il; Lim, Jong-Seok; Lee, Myeong-Sok; Oh, Ki-Sook; Yang, Young
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1608-1618
- ISSN:
- 1388-1981
- Subject:
- adipogenesis; animal disease models; dephosphorylation; high fat diet; mice; obesity; okadaic acid; phosphorylation; transcription factors
- Abstract:
- ... It is known that protein phosphatase 2A (PP2A) expression is increased in high-fat diet (HFD)-induced obese mice, but the role of PP2A in adipogenesis as well as obesity remains to be addressed. In this study, the role of PP2A in adipogenesis was explored. Preadipocytes were treated with okadaic acid (OA) during adipogenesis and the degree of adipogenesis was determined. The OA treatment blocked a ...
- DOI:
- 10.1016/j.bbalip.2014.08.008
-
http://dx.doi.org/10.1016/j.bbalip.2014.08.008
- Author:
- Sreckovic, Ivana; Birner-Gruenberger, Ruth; Besenboeck, Carolin; Miljkovic, Milica; Stojakovic, Tatjana; Scharnagl, Hubert; Marsche, Gunther; Lang, Uwe; Kotur-Stevuljevic, Jelena; Jelic-Ivanovic, Zorana; Desoye, Gernot; Wadsack, Christian
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1619-1627
- ISSN:
- 1388-1981
- Subject:
- antioxidant activity; antioxidants; aryldialkylphosphatase; cholesterol; cholesteryl esters; endothelial cells; fetal macrosomia; gel electrophoresis; gene expression regulation; gestational diabetes; high density lipoprotein; inflammation; innate immunity; lipid metabolism; neonates; phospholipids; pregnancy; protein synthesis; proteomics; risk; triacylglycerols
- Abstract:
- ... Gestational diabetes mellitus (GDM) is related to neonatal macrosomia and an increased risk of vascular events. We hypothesized that GDM exerts qualitative effects on neonatal high-density lipoprotein (HDL). HDL was isolated from control (n=11) and GDM maternal/neonatal donors (n=9) and subjected to shotgun proteomics. Differences in HDL mobility were assessed by FPLC and native gel-electrophoresi ...
- DOI:
- 10.1016/j.bbalip.2014.07.021
-
http://dx.doi.org/10.1016/j.bbalip.2014.07.021
- Author:
- Jonnalagadda, Deepa; Sunkara, Manjula; Morris, Andrew J.; Whiteheart, Sidney W.
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1581-1589
- ISSN:
- 1388-1981
- Subject:
- G-protein coupled receptors; agonists; albumins; exocytosis; fluorescence; fractionation; granules; immunity; lipids; membrane fusion; mice; organelles; plasma membrane; platelet activation; secretion; sphingosine
- Abstract:
- ... Sphingosine-1-phosphate (S1P) is an intracellularly generated bioactive lipid essential for development, vascular integrity, and immunity. These functions are mediated by S1P-selective cell surface G-protein coupled receptors. S1P signaling therefore requires extracellular release of this lipid. Several cell types release S1P and evidence for both plasma membrane transporter-mediated and vesicle-d ...
- DOI:
- 10.1016/j.bbalip.2014.08.013
- PubMed:
- 25158625
- PubMed Central:
- PMC4223867
-
http://dx.doi.org/10.1016/j.bbalip.2014.08.013
- Author:
- Zhou, Joseph Yi; Li, Lixin
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1590-1595
- ISSN:
- 1388-1981
- Subject:
- adipocytes; adipogenesis; adults; brown adipose tissue; cardiovascular diseases; cold; diabetes; energy; genes; heat; infants; microRNA; mitochondria; myoblasts; neoplasms; obesity; temperature; transcription (genetics)
- Abstract:
- ... The recent discovery of microRNA, thousands of short, non-coding strands of RNA that regulate gene expressions on the transcriptional level throughout the body, raises the possibility of their roles as therapeutic targets in the treatment of a diverse range of diseases including diabetes, cancer, cardiovascular disease, and obesity. Specifically, their potential as therapeutic targets in the treat ...
- DOI:
- 10.1016/j.bbalip.2014.08.009
-
http://dx.doi.org/10.1016/j.bbalip.2014.08.009
- Author:
- Nguyen, Theresa P.T.; Casarin, Alberto; Desbats, Maria Andrea; Doimo, Mara; Trevisson, Eva; Santos-Ocaña, Carlos; Navas, Placido; Clarke, Catherine F.; Salviati, Leonardo
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1628-1638
- ISSN:
- 1388-1981
- Subject:
- Escherichia coli; RNA; Saccharomyces cerevisiae; biosynthesis; coenzyme Q10; gene overexpression; genes; humans; immunoblotting; kidneys; methyltransferases; mitochondria; mitochondrial membrane; molecular weight; mutants; neurodegenerative diseases; point mutation; polypeptides; proteins; tissues; yeasts
- Abstract:
- ... Coq5 catalyzes the only C-methylation involved in the biosynthesis of coenzyme Q (Q or ubiquinone) in humans and yeast Saccharomyces cerevisiae. As one of eleven polypeptides required for Q production in yeast, Coq5 has also been shown to assemble with the multi-subunit complex termed the CoQ-synthome. In humans, mutations in several COQ genes cause primary Q deficiency, and a decrease in Q biosyn ...
- DOI:
- 10.1016/j.bbalip.2014.08.007
- PubMed:
- 25152161
- PubMed Central:
- PMC4331671
-
http://dx.doi.org/10.1016/j.bbalip.2014.08.007