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You searched for: Journal BBA - Molecular and Cell Biology of Lipids Remove constraint Journal: BBA - Molecular and Cell Biology of Lipids Publication Year 2014 Remove constraint Publication Year: 2014 Source 2014 v.1841 Remove constraint Source: 2014 v.1841
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1. ABCG1 is involved in vitamin E efflux

Author:
Olivier, Maryline; Bott, Romain; Frisdal, Eric; Nowicki, Marion; Plengpanich, Wanee; Desmarchelier, Charles; Roi, Stéphanie; Quinn, Carmel M.; Gelissen, Ingrid; Jessup, Wendy; Van Eck, Miranda; Guérin, Maryse; Le Goff, Wilfried; Reboul, Emmanuelle
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1741-1751
ISSN:
1388-1981
Subject:
cholesterol; gamma-tocopherol; hepatocytes; humans; lipoproteins; liver; macrophages; mice; physiological transport; rats; tissues; transporters
Abstract:
... Vitamin E membrane transport has been shown to involve the cholesterol transporters SR-BI, ABCA1 and NPC1L1. Our aim was to investigate the possible participation of another cholesterol transporter in cellular vitamin E efflux: ABCG1. In Abcg1-deficient mice, vitamin E concentration was reduced in plasma lipoproteins whereas most tissues displayed a higher vitamin E content compared to wild-type m ...
DOI:
10.1016/j.bbalip.2014.10.003

2. Characterization of fatty acid binding and transfer from ∆98∆, a functional all-β abridged form of IFABP

Author:
Rodriguez Sawicki, Luciana; Guerbi, María Ximena; Falomir Lockhart, Lisandro Jorge; Curto, Lucrecia María; Delfino, José María; Córsico, Betina; Franchini, Gisela Raquel
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1733-1740
ISSN:
1388-1981
Subject:
artificial membranes; fatty acid-binding proteins; fatty acids; ligands; proteolysis
Abstract:
... Intestinal fatty acid binding protein (IFABP) is an intracellular lipid binding protein whose specific functions within the cell are still uncertain. An abbreviated version of IFABP encompassing residues 29–126, dubbed Δ98Δ is a stable product of limited proteolysis with clostripain of holo-IFABP. Cumulative evidence shows that Δ98Δ adopts a stable, monomeric and functional fold, with compact core ...
DOI:
10.1016/j.bbalip.2014.09.022

3. Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues

Author:
Hansen, Ida R.; Jansson, Kim M.; Cannon, Barbara; Nedergaard, Jan
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1691-1699
ISSN:
1388-1981
Subject:
acclimation; adipocytes; autocrine signaling; brown adipose tissue; cafeteria foods; cell culture; cold; epididymis; gene expression; gene expression regulation; high fat diet; males; mice; muscles; obesogenic diet; signal peptide; white adipose tissue
Abstract:
... Based on results from a signal sequence trap, we investigated chemerin gene expression in brown adipose tissue. Male NMRI mice were exposed to 30, 22 or 4°C for 3weeks, or were fed control (chow) diet, cafeteria diet or high-fat diet at thermoneutrality for the same time. In brown adipose tissue, cold acclimation strongly diminished chemerin gene expression, whereas obesogenic diets augmented expr ...
DOI:
10.1016/j.bbalip.2014.09.003

4. Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation

Author:
Abdel Shakor, Abo Bakr; Atia, Mona; Ismail, Ismail Ahmed; Alshehri, Ali; El-Refaey, Hesham; Kwiatkowska, Katarzyna; Sobota, Andrzej
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1672-1682
ISSN:
1388-1981
Subject:
P-glycoproteins; antineoplastic agents; apoptosis; caspase-3; cell viability; ceramides; curcumin; cyclosporine; genes; humans; leukemia; multiple drug resistance; neoplasm cells; sphingomyelins
Abstract:
... Most anti-cancer agents induce apoptosis, however, a development of multidrug resistance in cancer cells and defects in apoptosis contribute often to treatment failure. Here, the mechanism of curcumin-induced apoptosis was investigated in human leukemia HL60 cells and their HL60/VCR multidrug-resistant counterparts. In both cell lines curcumin induced a bi-phasic ceramide generation with a slow ph ...
DOI:
10.1016/j.bbalip.2014.09.006

5. Fluorescence study of domain structure and lipid interaction of human apolipoproteins E3 and E4

Author:
Mizuguchi, Chiharu; Hata, Mami; Dhanasekaran, Padmaja; Nickel, Margaret; Okuhira, Keiichiro; Phillips, Michael C.; Lund-Katz, Sissel; Saito, Hiroyuki
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1716-1724
ISSN:
1388-1981
Subject:
apolipoprotein E; cholesterol metabolism; energy transfer; fluorescence; guanidines; humans; mutation; phosphatidylcholines
Abstract:
... Human apolipoprotein E (apoE) isoforms exhibit different conformational stabilities and lipid-binding properties that give rise to altered cholesterol metabolism among the isoforms. Using Trp-substituted mutations and site-directed fluorescence labeling, we made a comprehensive comparison of the conformational organization of the N- and C-terminal domains and lipid interactions between the apoE3 a ...
DOI:
10.1016/j.bbalip.2014.09.019
PubMed:
25281910
PubMed Central:
PMC4342298

6. Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length

Author:
Park, Woo-Jae; Park, Joo-Won; Merrill, Alfred H.; Storch, Judith; Pewzner-Jung, Yael; Futerman, Anthony H.
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1754-1766
ISSN:
1388-1981
Subject:
hepatocytes; fatty acids; Dependoparvovirus; high fat diet; liver; proteins; weight gain; adipose tissue; skeletal muscle; triacylglycerols; mice; insulin; ceramides; sphingosine N-acyltransferase
Abstract:
... Ceramide synthase 2 (CerS2) null mice cannot synthesize very-long acyl chain (C22–C24) ceramides resulting in significant alterations in the acyl chain composition of sphingolipids. We now demonstrate that hepatic triacylglycerol (TG) levels are reduced in the liver but not in the adipose tissue or skeletal muscle of the CerS2 null mouse, both before and after feeding with a high fat diet (HFD), w ...
DOI:
10.1016/j.bbalip.2014.09.009
PubMed:
25241943
PubMed Central:
PMC4406097

7. Localization of VE-cadherin in plasmalemmal cholesterol rich microdomains and the effects of cholesterol depletion on VE-cadherin mediated cell–cell adhesion

Author:
Baumgartner, Werner; Weth, Agnes; Gutberlet, Judith; Harms, Gregory; Groschner, Klaus
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1725-1732
ISSN:
1388-1981
Subject:
adherens junctions; adhesion; cadherins; cell adhesion; cell fractionation; cholesterol; endothelial cells; fluorescence microscopy; fractionation; microfilaments
Abstract:
... VE-cadherin is the predominant adhesion molecule in vascular endothelial cells being responsible for maintenance of the endothelial barrier function by forming adhesive contacts (adherens junctions) to neighbouring cells. We found by use of single molecule fluorescence microscopy that VE-cadherin is localised in preformed clusters when not inside adherens junctions. These clusters depend on the in ...
DOI:
10.1016/j.bbalip.2014.08.016

8. One precursor, three apolipoproteins: The relationship between two crustacean lipoproteins, the large discoidal lipoprotein and the high density lipoprotein/β-glucan binding protein

Author:
Stieb, Stefanie; Roth, Ziv; Dal Magro, Christina; Fischer, Sabine; Butz, Eric; Sagi, Amir; Khalaila, Isam; Lieb, Bernhard; Schenk, Sven; Hoeger, Ulrich
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1700-1708
ISSN:
1388-1981
Subject:
Astacus leptodactylus; Macrobrachium rosenbergii; amino acids; apolipoproteins; binding capacity; crayfish; hepatopancreas; high density lipoprotein; lipid transfer proteins; mass spectrometry; open reading frames; peptides; shrimp; transcriptome
Abstract:
... The novel discoidal lipoprotein (dLp) recently detected in the crayfish, differs from other crustacean lipoproteins in its large size, apoprotein composition and high lipid binding capacity. We identified the dLp sequence by transcriptome analyses of the hepatopancreas and mass spectrometry. Further de novo assembly of the NGS data followed by BLAST searches using the sequence of the high density ...
DOI:
10.1016/j.bbalip.2014.09.020

9. Phospholipase A2 regulation of lipid droplet formation

Author:
Guijas, Carlos; Rodríguez, Juan P.; Rubio, Julio M.; Balboa, María A.; Balsinde, Jesús
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1661-1671
ISSN:
1388-1981
Subject:
atherosclerosis; biogenesis; biosynthesis; carcinogenesis; cell physiology; diabetes; droplets; fatty acids; fatty liver; homeostasis; inflammation; leukocytes; neoplasms; neurodegenerative diseases; obesity; organelles; pathophysiology; phospholipase A2; phospholipids
Abstract:
... The classical regard of lipid droplets as mere static energy-storage organelles has evolved dramatically. Nowadays these organelles are known to participate in key processes of cell homeostasis, and their abnormal regulation is linked to several disorders including metabolic diseases (diabetes, obesity, atherosclerosis or hepatic steatosis), inflammatory responses in leukocytes, cancer development ...
DOI:
10.1016/j.bbalip.2014.10.004

10. Psoriasis decreases the anti-oxidation and anti-inflammation properties of high-density lipoprotein

Author:
He, Lei; Qin, Shucun; Dang, Lin; Song, Guohua; Yao, Shutong; Yang, Nana; Li, Yuzhen
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1709-1715
ISSN:
1388-1981
Subject:
C-reactive protein; anti-inflammatory activity; apoptosis; cardiovascular diseases; cell movement; correlation; cross-sectional studies; endothelial cells; high density lipoprotein cholesterol; hyperlipidemia; in vitro studies; interleukin-6; low density lipoprotein; malondialdehyde; monocytes; necrosis; oxidation; patients; psoriasis; tumor necrosis factor-alpha
Abstract:
... Psoriasis is a chronic inflammatory skin disease, which has been linked to dyslipidemia with potential functional impairment of lipoproteins. This cross-sectional study was designed to characterize the biological activities of plasma lipoproteins in 25 patients with psoriasis and 25 age- and sex-matched healthy controls.In the present study, we found that plasma levels of high-density lipoprotein ...
DOI:
10.1016/j.bbalip.2014.09.008

11. Rainbow trout (Oncorhynchus mykiss) Elovl5 and Elovl2 differ in selectivity for elongation of omega-3 docosapentaenoic acid

Author:
Gregory, Melissa K.; James, Michael J.
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1656-1660
ISSN:
1388-1981
Subject:
Oncorhynchus mykiss; alpha-linolenic acid; docosahexaenoic acid; docosapentaenoic acid; eicosapentaenoic acid; enzymes; fish; gene expression; liver; mammals; omega-3 fatty acids; yeasts
Abstract:
... The synthesis of the omega-3 long-chain polyunsaturated fatty acids (LCPUFA) eicosapentaenoic acid (EPA; 20:5n−3) and docosahexaenoic acid (DHA; 22:6n−3) from dietary α-linolenic acid (ALA; 18:3n−3) requires three desaturation and three elongation steps in vertebrates. The elongation of EPA to docosapentaenoic acid (DPA; 22:5n−3) can be catalysed by the elongase enzymes Elovl5 or Elovl2, but furth ...
DOI:
10.1016/j.bbalip.2014.10.001

12. Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity

Author:
Bosma, Madeleen; Dapito, Dianne H.; Drosatos-Tampakaki, Zoi; Huiping-Son, Ni; Huang, Li-Shin; Kersten, Sander; Drosatos, Konstantinos; Goldberg, Ira J.
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1648-1655
ISSN:
1388-1981
Subject:
cardiomyocytes; droplets; endoplasmic reticulum; free fatty acids; gene expression; humans; lipid metabolism; lipotoxicity; models; oleic acid; palmitates; phosphorylation; triacylglycerols
Abstract:
... We used human cardiomyocyte-derived cells to create an in vitro model to study lipid metabolism and explored the effects of PPARγ, ACSL1 and ATGL on fatty acid-induced ER stress. Compared to oleate, palmitate treatment resulted in less intracellular accumulation of lipid droplets and more ER stress, as measured by upregulation of CHOP, ATF6 and GRP78 gene expression and phosphorylation of eukaryot ...
DOI:
10.1016/j.bbalip.2014.09.012
PubMed:
25251292
PubMed Central:
PMC4342292

13. Transgenic CGI-58 expression in macrophages alleviates the atherosclerotic lesion development in ApoE knockout mice

Author:
Xie, Ping; Zeng, Xu; Xiao, Jing; Sun, Bing; Yang, Dan
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1683-1690
ISSN:
1388-1981
Subject:
aorta; atherosclerosis; blood serum; bone marrow; cholesterol metabolism; genes; high density lipoprotein cholesterol; homeostasis; interleukin-6; knockout mutants; macrophages; mice; phenotype; transgenic animals; triacylglycerol lipase; triacylglycerols; tumor necrosis factor-alpha
Abstract:
... Comparative Gene Identification-58 (CGI-58), as an adipose triglyceride lipase (ATGL) activator, strongly increases ATGL-mediated triglyceride (TG) catabolism. Previous studies have shown that CGI-58 affects intestinal cholesterol homeostasis independently of ATGL activity. Therefore, we hypothesized that CGI-58 was involved in macrophage cholesterol metabolism and consequently atherosclerotic les ...
DOI:
10.1016/j.bbalip.2014.08.014

14. Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells

Author:
Patwardhan, Gauri A.; Hosain, Salman B.; Liu, David X.; Khiste, Sachin K.; Zhao, Yunfeng; Bielawski, Jacek; Jazwinski, S. Michal; Liu, Yong-Yu
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1571-1580
ISSN:
1388-1981
Subject:
DNA; animal ovaries; apoptosis; bioactive properties; ceramides; epigenetics; genes; heterozygosity; messenger RNA; mutants; neoplasm cells; ovarian neoplasms; phosphoprotein phosphatase; proteins
Abstract:
... Mutants of tumor suppressor p53 not only lose the activity in genome stabilizing and in tumor suppression, but also exhibit oncogenic function in cancer cells. Most efforts in restoring p53 biological activity focus on either altering mutant-protein conformation or introducing an exogenous p53 gene into cells to eliminate p53-mutant cancer cells. Being different from these, we report that ceramide ...
DOI:
10.1016/j.bbalip.2014.08.017
PubMed:
25195822
PubMed Central:
PMC4188706

15. Creatine reduces hepatic TG accumulation in hepatocytes by stimulating fatty acid oxidation

Author:
da Silva, Robin P.; Kelly, Karen B.; Leonard, Kelly-Ann; Jacobs, René L.
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1639-1646
ISSN:
1388-1981
Subject:
beta oxidation; creatine; dose response; fatty liver; fibrosis; hepatocytes; hepatoma; high fat diet; lipid peroxidation; lipids; lipolysis; liver; messenger RNA; radiolabeling; rats; secretion; transcription (genetics)
Abstract:
... Non-alcoholic fatty liver disease encompasses a wide spectrum of liver damage including steatosis, non-alcoholic steatohepatitis, fibrosis and cirrhosis. We have previously reported that creatine supplementation prevents hepatic steatosis and lipid peroxidation in rats fed a high-fat diet. In this study, we employed oleate-treated McArdle RH-7777 rat hepatoma cells to investigate the role of creat ...
DOI:
10.1016/j.bbalip.2014.09.001

16. Dephosphorylation of CCAAT/enhancer-binding protein β by protein phosphatase 2A containing B56δ is required at the early time of adipogenesis

Author:
Park, Miyoung; Choi, Yeon A; Lee, Hee Gu; Kim, Keun Il; Lim, Jong-Seok; Lee, Myeong-Sok; Oh, Ki-Sook; Yang, Young
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1608-1618
ISSN:
1388-1981
Subject:
adipogenesis; animal disease models; dephosphorylation; high fat diet; mice; obesity; okadaic acid; phosphorylation; transcription factors
Abstract:
... It is known that protein phosphatase 2A (PP2A) expression is increased in high-fat diet (HFD)-induced obese mice, but the role of PP2A in adipogenesis as well as obesity remains to be addressed. In this study, the role of PP2A in adipogenesis was explored. Preadipocytes were treated with okadaic acid (OA) during adipogenesis and the degree of adipogenesis was determined. The OA treatment blocked a ...
DOI:
10.1016/j.bbalip.2014.08.008

17. Gestational diabetes mellitus modulates neonatal high-density lipoprotein composition and its functional heterogeneity

Author:
Sreckovic, Ivana; Birner-Gruenberger, Ruth; Besenboeck, Carolin; Miljkovic, Milica; Stojakovic, Tatjana; Scharnagl, Hubert; Marsche, Gunther; Lang, Uwe; Kotur-Stevuljevic, Jelena; Jelic-Ivanovic, Zorana; Desoye, Gernot; Wadsack, Christian
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1619-1627
ISSN:
1388-1981
Subject:
antioxidant activity; antioxidants; aryldialkylphosphatase; cholesterol; cholesteryl esters; endothelial cells; fetal macrosomia; gel electrophoresis; gene expression regulation; gestational diabetes; high density lipoprotein; inflammation; innate immunity; lipid metabolism; neonates; phospholipids; pregnancy; protein synthesis; proteomics; risk; triacylglycerols
Abstract:
... Gestational diabetes mellitus (GDM) is related to neonatal macrosomia and an increased risk of vascular events. We hypothesized that GDM exerts qualitative effects on neonatal high-density lipoprotein (HDL). HDL was isolated from control (n=11) and GDM maternal/neonatal donors (n=9) and subjected to shotgun proteomics. Differences in HDL mobility were assessed by FPLC and native gel-electrophoresi ...
DOI:
10.1016/j.bbalip.2014.07.021

18. Granule-mediated release of sphingosine-1-phosphate by activated platelets

Author:
Jonnalagadda, Deepa; Sunkara, Manjula; Morris, Andrew J.; Whiteheart, Sidney W.
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1581-1589
ISSN:
1388-1981
Subject:
G-protein coupled receptors; agonists; albumins; exocytosis; fluorescence; fractionation; granules; immunity; lipids; membrane fusion; mice; organelles; plasma membrane; platelet activation; secretion; sphingosine
Abstract:
... Sphingosine-1-phosphate (S1P) is an intracellularly generated bioactive lipid essential for development, vascular integrity, and immunity. These functions are mediated by S1P-selective cell surface G-protein coupled receptors. S1P signaling therefore requires extracellular release of this lipid. Several cell types release S1P and evidence for both plasma membrane transporter-mediated and vesicle-d ...
DOI:
10.1016/j.bbalip.2014.08.013
PubMed:
25158625
PubMed Central:
PMC4223867

19. MicroRNAs are key regulators of brown adipogenesis

Author:
Zhou, Joseph Yi; Li, Lixin
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1590-1595
ISSN:
1388-1981
Subject:
adipocytes; adipogenesis; adults; brown adipose tissue; cardiovascular diseases; cold; diabetes; energy; genes; heat; infants; microRNA; mitochondria; myoblasts; neoplasms; obesity; temperature; transcription (genetics)
Abstract:
... The recent discovery of microRNA, thousands of short, non-coding strands of RNA that regulate gene expressions on the transcriptional level throughout the body, raises the possibility of their roles as therapeutic targets in the treatment of a diverse range of diseases including diabetes, cancer, cardiovascular disease, and obesity. Specifically, their potential as therapeutic targets in the treat ...
DOI:
10.1016/j.bbalip.2014.08.009

20. Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis

Author:
Nguyen, Theresa P.T.; Casarin, Alberto; Desbats, Maria Andrea; Doimo, Mara; Trevisson, Eva; Santos-Ocaña, Carlos; Navas, Placido; Clarke, Catherine F.; Salviati, Leonardo
Source:
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1628-1638
ISSN:
1388-1981
Subject:
Escherichia coli; RNA; Saccharomyces cerevisiae; biosynthesis; coenzyme Q10; gene overexpression; genes; humans; immunoblotting; kidneys; methyltransferases; mitochondria; mitochondrial membrane; molecular weight; mutants; neurodegenerative diseases; point mutation; polypeptides; proteins; tissues; yeasts
Abstract:
... Coq5 catalyzes the only C-methylation involved in the biosynthesis of coenzyme Q (Q or ubiquinone) in humans and yeast Saccharomyces cerevisiae. As one of eleven polypeptides required for Q production in yeast, Coq5 has also been shown to assemble with the multi-subunit complex termed the CoQ-synthome. In humans, mutations in several COQ genes cause primary Q deficiency, and a decrease in Q biosyn ...
DOI:
10.1016/j.bbalip.2014.08.007
PubMed:
25152161
PubMed Central:
PMC4331671