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BBA - Molecular and Cell Biology of Lipids
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7986-2014
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2014 v.1841
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- Author:
- Maryline Olivier; Romain Bott; Eric Frisdal; Marion Nowicki; Wanee Plengpanich; Charles Desmarchelier; Stéphanie Roi; Carmel M. Quinn; Ingrid Gelissen; Wendy Jessup; Miranda Van Eck; Maryse Guérin; Wilfried Le Goff; Emmanuelle Reboul
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1741-1751
- ISSN:
- 1388-1981
- Subject:
- cholesterol; gamma-tocopherol; hepatocytes; humans; lipoproteins; liver; macrophages; mice; physiological transport; rats; tissues; transporters
- Abstract:
- ... Vitamin E membrane transport has been shown to involve the cholesterol transporters SR-BI, ABCA1 and NPC1L1. Our aim was to investigate the possible participation of another cholesterol transporter in cellular vitamin E efflux: ABCG1. In Abcg1-deficient mice, vitamin E concentration was reduced in plasma lipoproteins whereas most tissues displayed a higher vitamin E content compared to wild-type m ...
- DOI:
- 10.1016/j.bbalip.2014.10.003
- https://doi.org/10.1016/j.bbalip.2014.10.003
- Author:
- Maria Bloksgaard; Ditte Neess; Nils J. Færgeman; Susanne Mandrup
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 369-376
- ISSN:
- 1388-1981
- Subject:
- acyl coenzyme A; alopecia; binding proteins; esters; fur; genes; mice; phenotype; tissues; very long chain fatty acids
- Abstract:
- ... The acyl-CoA binding protein (ACBP) is a 10kDa intracellular protein expressed in all eukaryotic species and mammalian tissues investigated. It binds acyl-CoA esters with high specificity and affinity and is thought to act as an intracellular transporter of acyl-CoA esters between different enzymatic systems; however, the precise function remains unknown. ACBP is expressed at relatively high level ...
- DOI:
- 10.1016/j.bbalip.2013.09.013
- https://doi.org/10.1016/j.bbalip.2013.09.013
- Author:
- Harald M. Nagy; Margret Paar; Christoph Heier; Tarek Moustafa; Peter Hofer; Guenter Haemmerle; Achim Lass; Rudolf Zechner; Monika Oberer; Robert Zimmermann
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 588-594
- ISSN:
- 1388-1981
- Subject:
- adipose tissue; diacylglycerols; fatty acid composition; fatty acids; free fatty acids; hormones; lipolysis; monoacylglycerols; precipitin tests; protein-protein interactions; regulatory proteins; triacylglycerol lipase; triacylglycerols
- Abstract:
- ... Adipose triglyceride lipase (ATGL) is required for efficient mobilization of triglyceride (TG) stores in adipose tissue and non-adipose tissues. Therefore, ATGL strongly determines the availability of fatty acids for metabolic reactions. ATGL activity is regulated by a complex network of lipolytic and anti-lipolytic hormones. These signals control enzyme expression and the interaction of ATGL with ...
- DOI:
- 10.1016/j.bbalip.2014.01.005
- PubMed:
- 24440819
- PubMed Central:
- PMC3988850
- https://doi.org/10.1016/j.bbalip.2014.01.005
- Author:
- Valeria Winslow; Rachel Vaivoda; Aleksandr Vasilyev; David Dombkowski; Karim Douaidy; Christopher Stark; Justin Drake; Evin Guilliams; Dharamainder Choudhary; Frederic Preffer; Ivaylo Stoilov; Peter Christmas
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 868-879
- ISSN:
- 1388-1981
- Subject:
- alleles; animal models; biochemical pathways; enzymes; exons; flow cytometry; humans; immunohistochemistry; inflammation; ischemia; kidneys; metabolism; mice; neutrophils; oxidation; urea nitrogen
- Abstract:
- ... Inflammatory responses to infection and injury must be restrained and negatively regulated to minimize damage to host tissue. One proposed mechanism involves enzymatic inactivation of the pro-inflammatory mediator leukotriene B4, but it is difficult to dissect the roles of various metabolic enzymes and pathways. A primary candidate for a regulatory pathway is omega oxidation of leukotriene B4 in n ...
- DOI:
- 10.1016/j.bbalip.2014.03.002
- PubMed:
- 24632148
- PubMed Central:
- PMC4013684
- https://doi.org/10.1016/j.bbalip.2014.03.002
- Author:
- Luz Ángela Cuellar; Eduardo Daniel Prieto; Laura Virginia Cabaleiro; Horacio Alberto Garda
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 180-189
- ISSN:
- 1388-1981
- Subject:
- apolipoprotein A-I; cholesterol; cysteine; dialysis; energy transfer; fluorescence; gels; high density lipoprotein; macrophages; mutants; phase transition; phospholipids; temperature; tryptophan
- Abstract:
- ... Discoidal high-density lipoproteins (D-HDL) are critical intermediates in reverse cholesterol transport. Most of the present knowledge of D-HDL is based on studies with reconstituted lipoprotein complexes of apolipoprotein A-I (apoA-I) obtained by cholate dialysis (CD). D-HDL can also be generated by the direct microsolubilization (DM) of phospholipid vesicles at the gel/fluid phase transition tem ...
- DOI:
- 10.1016/j.bbalip.2013.10.017
- https://doi.org/10.1016/j.bbalip.2013.10.017
- Author:
- Anouar Hafiane; John K. Bielicki; Jan O. Johansson; Jacques Genest
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1498-1512
- ISSN:
- 1388-1981
- Subject:
- apolipoprotein E; biogenesis; cardiovascular diseases; cholesterol; enzymes; hepatocytes; high density lipoprotein; physiology; synthetic peptides
- Abstract:
- ... Modulation of the reverse cholesterol transport (RCT) pathway may provide a therapeutic target for the prevention and treatment of atherosclerotic cardiovascular disease (CVD). In the present study, we evaluated a novel 26-amino acid apolipoprotein mimetic peptide (ATI-5261) designed from the carboxyl terminal of apoE, in its ability to mimic apoA-I functionality in RCT in vitro. Our data shows th ...
- DOI:
- 10.1016/j.bbalip.2014.07.018
- https://doi.org/10.1016/j.bbalip.2014.07.018
- Author:
- Wenhui Jiang; Besim Ogretmen
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 783-792
- ISSN:
- 1388-1981
- Subject:
- autophagy; cell viability; ceramides; humans; inflammation; mechanism of action; metabolism; metastasis; neoplasms; signal transduction
- Abstract:
- ... Sphingolipid molecules act as bioactive lipid messengers and exert their actions on the regulation of various cellular signaling pathways. Sphingolipids play essential roles in numerous cellular functions, including controlling cell inflammation, proliferation, death, migration, senescence, tumor metastasis and/or autophagy. Dysregulated sphingolipid metabolism has been also implicated in many hum ...
- DOI:
- 10.1016/j.bbalip.2013.09.005
- PubMed:
- 24055889
- PubMed Central:
- PMC3960371
- https://doi.org/10.1016/j.bbalip.2013.09.005
- Author:
- Bing Fang; Ming Zhang; Mai Tian; Lu Jiang; Hui Yuan Guo; Fa Zheng Ren
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 535-543
- ISSN:
- 1388-1981
- Subject:
- Western blotting; antineoplastic activity; apoptosis; calorimetry; circular dichroism spectroscopy; death domain receptors; flow cytometry; fluorescence emission spectroscopy; heat treatment; hydrogen bonding; hydrophobicity; lactalbumin; lactoferrin; lethal dose 50; methylene blue; neoplasm cells; oleic acid; titration; tryptophan; van der Waals forces
- Abstract:
- ... α-Lactalbumin (α-LA) can bind oleic acid (OA) to form HAMLET-like complexes, which exhibited highly selective anti-tumor activity in vitro and in vivo. Considering the structural similarity to α-LA, we conjectured that lactoferrin (LF) could also bind OA to obtain a complex with anti-tumor activity. In this study, LF–OA was prepared and its activity and structural changes were compared with α-LA–O ...
- DOI:
- 10.1016/j.bbalip.2013.12.008
- https://doi.org/10.1016/j.bbalip.2013.12.008
- Author:
- Doris Höglinger; André Nadler; Carsten Schultz
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1085-1096
- ISSN:
- 1388-1981
- Subject:
- cell communication; cells; light; lipids
- Abstract:
- ... Lipid derivatives that can be activated by light, often referred to as ‘caged’ lipids, are useful tools to manipulate intact cells non-invasively. Here we focus on experimental approaches that have made use of caged lipids. Apart from summarizing the recent advances and available tools in the field, we strive to highlight the experimental challenges that arise from lipid-specific biophysical prope ...
- DOI:
- 10.1016/j.bbalip.2014.03.012
- https://doi.org/10.1016/j.bbalip.2014.03.012
- Author:
- Hong-mei Gu; Fa-qi Wang; Da-wei Zhang
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 847-858
- ISSN:
- 1388-1981
- Subject:
- ABC transporters; agonists; alanine; binding sites; cholesterol; high density lipoprotein; liver; macrophages; mutants; small interfering RNA; tyrosine
- Abstract:
- ... ATP-binding cassette transporter G1 (ABCG1) plays an important role in macrophage reverse cholesterol transport in vivo by promoting cholesterol efflux onto lipidated apoA-I. However, the underlying mechanism is unclear. Here, we found that ABCG1 co-immunoprecipitated with caveolin-1 (CAV1) but not with flotillin-1 and -2. Knockdown of CAV1 expression using siRNAs significantly reduced ABCG1-media ...
- DOI:
- 10.1016/j.bbalip.2014.02.002
- https://doi.org/10.1016/j.bbalip.2014.02.002
- Author:
- Gauri A. Patwardhan; Salman B. Hosain; David X. Liu; Sachin K. Khiste; Yunfeng Zhao; Jacek Bielawski; S. Michal Jazwinski; Yong-Yu Liu
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1571-1580
- ISSN:
- 1388-1981
- Subject:
- DNA; animal ovaries; apoptosis; bioactive properties; ceramides; epigenetics; genes; heterozygosity; messenger RNA; mutants; neoplasm cells; ovarian neoplasms; phosphoprotein phosphatase; proteins
- Abstract:
- ... Mutants of tumor suppressor p53 not only lose the activity in genome stabilizing and in tumor suppression, but also exhibit oncogenic function in cancer cells. Most efforts in restoring p53 biological activity focus on either altering mutant-protein conformation or introducing an exogenous p53 gene into cells to eliminate p53-mutant cancer cells. Being different from these, we report that ceramide ...
- DOI:
- 10.1016/j.bbalip.2014.08.017
- PubMed:
- 25195822
- PubMed Central:
- PMC4188706
- https://doi.org/10.1016/j.bbalip.2014.08.017
- Author:
- Yoshikazu Uchida
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 453-462
- ISSN:
- 1388-1981
- Subject:
- apoptosis; cell membranes; ceramides; disease prevention; eczema; keratinocytes; mammals; metabolites; permeability; therapeutics; tissues
- Abstract:
- ... Ceramide, the backbone structure of all sphingolipids, as well as a minor component of cellular membranes, has a unique role in the skin, by forming the epidermal permeability barrier at the extracellular domains of the outermost layer of the skin, the stratum corneum, which is required for terrestrial mammalian survival. In contrast to the role of ceramide in forming the permeability barrier, the ...
- DOI:
- 10.1016/j.bbalip.2013.09.003
- PubMed:
- 24055887
- PubMed Central:
- PMC3943494
- https://doi.org/10.1016/j.bbalip.2013.09.003
- Author:
- Joo-Won Park; Woo-Jae Park; Anthony H. Futerman
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 671-681
- ISSN:
- 1388-1981
- Subject:
- biochemical pathways; cell communication; ceramides; human diseases; humans; mice; pathophysiology
- Abstract:
- ... Ceramide is located at a key hub in the sphingolipid metabolic pathway and also acts as an important cellular signaling molecule. Ceramide contains one acyl chain which is attached to a sphingoid long chain base via an amide bond, with the acyl chain varying in length and degree of saturation. The identification of a family of six mammalian ceramide synthases (CerS) that synthesize ceramide with d ...
- DOI:
- 10.1016/j.bbalip.2013.08.019
- https://doi.org/10.1016/j.bbalip.2013.08.019
- Author:
- Mariona Rabionet; Karin Gorgas; Roger Sandhoff
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 422-434
- ISSN:
- 1388-1981
- Subject:
- biosynthesis; ceramides; enzymes; homeostasis; lipid metabolism; pathogens; permeability; transcription factors; vertebrates; xenobiotics
- Abstract:
- ... The epidermis and in particular its outermost layer the stratum corneum provides terrestrial vertebrates with a pivotal defensive barrier against water loss, xenobiotics and harmful pathogens. A vital demand for this epidermal permeability barrier is the lipid-enriched lamellar matrix that embeds the enucleated corneocytes. Ceramides are the major components of these highly ordered intercellular l ...
- DOI:
- 10.1016/j.bbalip.2013.08.011
- https://doi.org/10.1016/j.bbalip.2013.08.011
- Author:
- Jo Ann Seng; Shane R. Ellis; Jessica R. Hughes; Alan T. Maccarone; Roger J.W. Truscott; Stephen J. Blanksby; Todd W. Mitchell
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1285-1291
- ISSN:
- 1388-1981
- Subject:
- cataract; cholesterol; desorption; electrospray ionization mass spectrometry; humans; sphingolipids; sulfates; thin layer chromatography
- Abstract:
- ... The lipidome of the human lens is unique in that cholesterol and dihydrosphingomyelin are the dominant classes. Moreover, the lens lipidome is not static with dramatic changes in several sphingolipid classes associated with both aging and cataract. Accordingly, there is a clear need to expand knowledge of the molecular species that constitute the human lens sphingolipidome. In this study, human le ...
- DOI:
- 10.1016/j.bbalip.2014.05.006
- https://doi.org/10.1016/j.bbalip.2014.05.006
- Author:
- Mariam Ayyash; Amal Algahmi; John Gillespie; Peter Oelkers
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 505-513
- ISSN:
- 1388-1981
- Subject:
- Candida albicans; Saccharomyces cerevisiae; acyl coenzyme A; acyltransferases; antifungal agents; esterification; fungi; gene expression; genes; homozygosity; mass spectrometry; palmitates; pathogens; phenotype; phospholipids; sterols; substrate specificity
- Abstract:
- ... Phospholipid remodeling involves phospholipase activity to remove acyl chains and acyltransferases to replace acyl chains. We here describe the characterization of a lysophospholipid acyltransferase in the opportunistic fungal pathogen, Candida albicans. Expression of this gene, C.a. LPT1, complemented the lysophospholipid acyltransferase defect in Saccharomyces cerevisiae strains lacking the homo ...
- DOI:
- 10.1016/j.bbalip.2013.12.015
- PubMed:
- 24406902
- PubMed Central:
- PMC4169218
- https://doi.org/10.1016/j.bbalip.2013.12.015
- Author:
- Hiroka Takase; Hiroki Furuchi; Masafumi Tanaka; Toshiyuki Yamada; Kyoko Matoba; Kenji Iwasaki; Toru Kawakami; Takahiro Mukai
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1467-1474
- ISSN:
- 1388-1981
- Subject:
- amino acids; amyloid; apolipoprotein A-I; blood proteins; blood serum; circular dichroism spectroscopy; denaturation; digestion; fluorescence; gel chromatography; gel electrophoresis; high density lipoprotein; humans; light scattering; particle size; patients; phospholipids; physicochemical properties; protein degradation; solubilization; temperature; transmission electron microscopy; trypsin
- Abstract:
- ... The acute-phase human protein serum amyloid A (SAA) is enriched in high-density lipoprotein (HDL) in patients with inflammatory diseases. Compared with normal HDL containing apolipoprotein A-I, which is the principal protein component, characteristics of acute-phase HDL containing SAA remain largely undefined. In the present study, we examined the physicochemical properties of reconstituted HDL (r ...
- DOI:
- 10.1016/j.bbalip.2014.07.012
- https://doi.org/10.1016/j.bbalip.2014.07.012
- Author:
- Ulrich Pecks; Markus G. Mohaupt; Matthias C. Hütten; Nicolai Maass; Werner Rath; Geneviève Escher
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 251-258
- ISSN:
- 1388-1981
- Subject:
- ABC transporters; apolipoprotein A-I; apolipoprotein E; atherosclerosis; blood serum; cholesterol; fetal development; fetus; high density lipoprotein; liver; low density lipoprotein; neonates; risk factors; umbilical cord
- Abstract:
- ... Fetal serum cholesterol and lipoprotein concentrations differ between preterm and term born neonates. An imbalance of the flow of cholesterol from the sites of synthesis or efflux from cells of peripheral organs to the liver, the reverse cholesterol transport (RCT), is linked to atherosclerosis and cardiovascular disease (CVD). Preterm delivery is a risk factor for the development of CVD. Thus, we ...
- DOI:
- 10.1016/j.bbalip.2013.11.008
- https://doi.org/10.1016/j.bbalip.2013.11.008
- Author:
- Kentaro Hanada
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 704-719
- ISSN:
- 1388-1981
- Subject:
- chemistry; choline; serine; phosphatidylcholines; phylogeny; cytosol; endoplasmic reticulum; transport proteins; threonine; bacteria; solutes; plasma membrane; humans; coevolution; ceramides; protists; exons; sphingomyelins; biosynthesis; genomics; protein-serine-threonine kinases; fungi
- Abstract:
- ... Life creates many varieties of lipids. The choline-containing sphingophospholipid sphingomyelin (SM) exists ubiquitously or widely in vertebrates and lower animals, but is absent or rare in bacteria, fungi, protists, and plants. In the biosynthesis of SM, ceramide, which is synthesized in the endoplasmic reticulum, is transported to the Golgi region by the ceramide transport protein CERT, probably ...
- DOI:
- 10.1016/j.bbalip.2013.06.006
- https://doi.org/10.1016/j.bbalip.2013.06.006
- Author:
- Cuiwen H. He; Letian X. Xie; Christopher M. Allan; UyenPhuong C. Tran; Catherine F. Clarke
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 630-644
- ISSN:
- 1388-1981
- Subject:
- biosynthesis; digitonin; gene overexpression; genes; mitochondria; models; molecular weight; mutants; polyacrylamide gel electrophoresis; polypeptides; ubiquinones; yeasts
- Abstract:
- ... Coenzyme Q biosynthesis in yeast requires a multi-subunit Coq polypeptide complex. Deletion of any one of the COQ genes leads to respiratory deficiency and decreased levels of the Coq4, Coq6, Coq7, and Coq9 polypeptides, suggesting that their association in a high molecular mass complex is required for stability. Over-expression of the putative Coq8 kinase in certain coq null mutants restores stea ...
- DOI:
- 10.1016/j.bbalip.2013.12.017
- PubMed:
- 24406904
- PubMed Central:
- PMC3959571
- https://doi.org/10.1016/j.bbalip.2013.12.017