PubAg

Main content area

Search

Did you mean to type: hashim or hashmi?

1  Search Results

1 entry found
Number of results to display per page

Search Results

1. Analysis of the local dynamics of human insulin and a rapid-acting insulin analog by hydrogen/deuterium exchange mass spectrometry

Author:
Hashii, Noritaka,   et al.   ; Nakazawa, Shiori; Ahn, Joomi; Hirose, Kenji; Kawasaki, Nana;     Show all 5 Authors
Source:
BBA - Proteins and Proteomics 2013 v.1834 pp. 1210-1214
ISSN:
1570-9639
Subject:
amino acids; deuterium; dimerization; humans; insulin; mass spectrometry; mutation; peptide mapping
Abstract:
... Human insulin and insulin lispro (lispro), a rapid-acting insulin analog, have identical primary structures, except for the transposition of a pair of amino acids. This mutation results in alterations in their higher order structures, with lispro dissociating more easily than human insulin. In our previous study performed using hydrogen/deuterium exchange mass spectrometry (HDX/MS), differences we ...
DOI:
10.1016/j.bbapap.2012.11.012