U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Journal name BBA advances Remove constraint Journal name: BBA advances Publication year rev 7978-2022 Remove constraint Publication year rev: 7978-2022 Source 2022 v.2 Remove constraint Source: 2022 v.2
Start Over

Search

20  Search Results

1 - 20 of 20
Number of results to display per page

Search Results

1. APP deficiency and HTRA2 modulates PrPc proteostasis in human cancer cells

Author:
Denis S.F. Biard; Rafika Jarray; Nicolas Rebergue; François Leteurtre; Dulce Papy-Garcia
Source:
BBA advances 2022 v.2 pp. 100035
ISSN:
2667-1603
Subject:
Alzheimer disease; amyloid; genes; homeostasis; humans; lipids; neoplasm cells; prions; protein synthesis; serine proteinases
Abstract:
... Cellular protein homeostasis (proteostasis) requires an accurate balance between protein biosynthesis, folding, and degradation, and its instability is causally related to human diseases and cancers. Here, we created numerous engineered cancer cell lines targeting APP (amyloid ß precursor protein) and/or PRNP (cellular prion) genes and we showed that APP knocking-down impaired PRNP mRNA level and ...
DOI:
10.1016/j.bbadva.2021.100035

2. Ab initio reconstruction of small angle scattering data for membrane proteins in copolymer nanodiscs

Author:
Kerrie A. Morrison; Aswin Doekhie; George M. Neville; Gareth J. Price; Paul Whitley; James Doutch; Karen J. Edler
Source:
BBA advances 2022 v.2 pp. 100033
ISSN:
2667-1603
Subject:
composite polymers; crystal structure; crystallization; gramicidin; lipids; models; neutrons; outer membrane proteins
Abstract:
... Small angle scattering techniques are beginning to be more widely utilised for structural analysis of biological systems. However, applying these techniques to study membrane proteins still remains problematic, due to sample preparation requirements and analysis of the resulting data. The development of styrene-maleic acid co-polymers (SMA) to extract membrane proteins into nanodiscs for further s ...
DOI:
10.1016/j.bbadva.2021.100033

3. Ameliorative effect of fluvoxamine against colon carcinogenesis via COX-2 blockade with oxidative and metabolic stress reduction at the cellular, molecular and metabolic levels

Author:
Pranesh Kumar; Mohit Kumar; Anurag Kumar Gautam; Archana Bharti Sonkar; Abhishek Verma; Amita Singh; Raquibun Nisha; Umesh Kumar; Dinesh Kumar; Tarun Mahata; Bolay Bhattacharya; Biswanath Maity; Abhishek Pandeya; Sunil Babu Gosipatala; Sudipta Saha
Source:
BBA advances 2022 v.2 pp. 100046
ISSN:
2667-1603
Subject:
animal models; carcinogenesis; colon; colorectal neoplasms; drug development; fluorouracil; immunoblotting; interleukin-6; metabolites; therapeutics
Abstract:
... Fluvoxamine's (FLX's) anticancer potential was investigated in pre-clinical research utilizing a DMH-induced colorectal cancer (CRC) rat model. qRT-PCR and immunoblotting validated the mechanistic investigation. The CRC condition was induced in response to COX-2 and IL-6, however, following FLX therapy, the condition returned to normal. FLX's anti-CRC potential may be attributable to COX-2 inhibit ...
DOI:
10.1016/j.bbadva.2022.100046

4. Cerosomes as skin repairing agent: Mode of action studies with a model stratum corneum layer at liquid/air and liquid/solid interfaces

Author:
Fabio Strati; Tetiana Mukhina; Reinhard H.H. Neubert; Lukas Opalka; Gerd Hause; Christian E.H. Schmelzer; Matthias Menzel; Gerald Brezesinski
Source:
BBA advances 2022 v.2 pp. 100039
ISSN:
2667-1603
Subject:
air; atopic dermatitis; ceramides; cholesterol; electrostatic interactions; evaporation; homeostasis; humans; hydrogen; liquid-air interface; liquids; mechanism of action; pH; phospholipids; psoriasis; soybeans; stearic acid
Abstract:
... The stratum corneum (SC) is the largest physical barrier of the human body. It protects against physical, chemical and biological damages, and avoids evaporation of water from the deepest skin layers. For its correct functioning, the homeostasis of the SC lipid matrix is fundamental. An alteration of the lipid matrix composition and in particular of its ceramide (CER) fraction can lead to the deve ...
DOI:
10.1016/j.bbadva.2021.100039

5. Characterization of the MYB-inhibitory potential of the Pan-HDAC inhibitor LAQ824

Author:
Maria V. Yusenko; Karl-Heinz Klempnauer
Source:
BBA advances 2022 v.2 pp. 100034
ISSN:
2667-1603
Subject:
apoptosis; drugs; myeloid leukemia; necroptosis; transcription factors; transcriptional activation
Abstract:
... A large body of work has shown that MYB acts as a master transcription regulator in hematopoietic cells and has pinpointed MYB as a potential drug target for acute myeloid leukemia (AML). Here, we have examined the MYB-inhibitory potential of the HDAC inhibitor LAQ824, which was identified in a screen for novel MYB inhibitors. We show that nanomolar concentrations of LAQ824 and the related HDAC in ...
DOI:
10.1016/j.bbadva.2021.100034

6. Comparative study of the hydrophobic interaction effect of pH and ionic strength on aggregation/emulsification of Congo red and amyloid fibrillation of insulin

Author:
Takahiro Kasai; Takashi Wada; Tsubasa Iijima; Yoshiko Minami; Tomoyo Sakaguchi; Ryotaro Koga; Tomoki Shiratori; Yuta Otsuka; Yohsuke Shimada; Yukiko Okayama; Satoru Goto
Source:
BBA advances 2022 v.2 pp. 100036
ISSN:
2667-1603
Subject:
amyloid; comparative study; egg albumen; electrostatic interactions; emulsifying; hens; hydrophobic bonding; hydrophobicity; insulin; ionic strength; isoelectric point; lysozyme; micelles; pH
Abstract:
... Amyloid fibrillation is provoked by the conformational rearrangement of its source. In our previous study, we claimed that the conformational rearrangement of hen egg white lysozyme requires intermolecular aggregation/packing induced. Our proposed causality of the aggregation and amyloid formation was demonstrated by the quantitative dependence of amyloid fibrillation on pH difference from its iso ...
DOI:
10.1016/j.bbadva.2021.100036

7. Fascin-1: Updated biological functions and therapeutic implications in cancer biology

Author:
Chien-Hsiu Li; Ming-Hsien Chan; Shu-Mei Liang; Yu-Chan Chang; Michael Hsiao
Source:
BBA advances 2022 v.2 pp. 100052
ISSN:
2667-1603
Subject:
actin; drug therapy; metastasis; multiomics; neoplasm progression; neoplasms; pseudopodia
Abstract:
... Filopodia are cellular protrusions that respond to a variety of stimuli. Filopodia are formed when actin is bound to the protein Fascin, which may play a crucial role in cellular interactions and motility during cancer metastasis. Significantly, the noncanonical features of Fascin-1 are gradually being clarified, including the related molecular network contributing to metabolic reprogramming, chem ...
DOI:
10.1016/j.bbadva.2022.100052

8. Influenza A virus hemagglutinin prevents extensive membrane damage upon dehydration

Author:
Maiara A. Iriarte-Alonso; Alexander M. Bittner; Salvatore Chiantia
Source:
BBA advances 2022 v.2 pp. 100048
ISSN:
2667-1603
Subject:
Influenza A virus; atomic force microscopy; cold; fluorescence correlation spectroscopy; fluorescence microscopy; glycoproteins; hemagglutinins; influenza; lipid bilayers; lipids; models; pathogenicity; rehydration; relative humidity; temperature; viruses; winter
Abstract:
... While the molecular mechanisms of virus infectivity are rather well known, the detailed consequences of environmental factors on virus biophysical properties are poorly understood. Seasonal influenza outbreaks are usually connected to the low winter temperature, but also to the low relative air humidity. Indeed, transmission rates increase in cold regions during winter. While low temperature must ...
DOI:
10.1016/j.bbadva.2022.100048

9. Interaction of a short antimicrobial peptide on charged lipid bilayer: A case study on aurein 1.2 peptide

Author:
Shuo Qian; Piotr A. Zolnierczuk
Source:
BBA advances 2022 v.2 pp. 100045
ISSN:
2667-1603
Subject:
Litoria; antimicrobial peptides; case studies; hydrophobicity; lipid bilayers; lipids; neutrons; spectroscopy; trees
Abstract:
... Aurein 1.2 (aurein) is a short but active α-helical antimicrobial peptide discovered in Australian tree frogs (Litoria aurea). It shows inhibition on a broad spectrum of bacteria and cancer cells. With well-defined helicity, amphipathicity, and cationic charges, it readily binds to membranes and causes membrane change and disruption. This study provides details on how aurein interacts with charged ...
DOI:
10.1016/j.bbadva.2022.100045

10. Sequencing the origins of life

Author:
Tony Z. Jia; Shota Nishikawa; Kosuke Fujishima
Source:
BBA advances 2022 v.2 pp. 100049
ISSN:
2667-1603
Subject:
biopolymers; evolution; polymerization; polypeptides
Abstract:
... One goal of origins of life research is to understand how primitive informational and catalytic biopolymers emerged and evolved. Recently, a number of sequencing techniques have been applied to analysis of replicating and evolving primitive biopolymer systems, providing a sequence-specific and high-resolution view of primitive chemical processes. Here, we review application of sequencing technique ...
DOI:
10.1016/j.bbadva.2022.100049

11. Subcellular localization of X-linked inhibitor of apoptosis protein (XIAP) in cancer: Does that matter?

Author:
BS Mendonça; CA Ferreira; RC Maia; G Nestal de Moraes
Source:
BBA advances 2022 v.2 pp. 100050
ISSN:
2667-1603
Subject:
apoptosis; cancer therapy; death; homeostasis; humans
Abstract:
... X-linked inhibitor of apoptosis protein (XIAP) finely tunes the balance between survival and death to control homeostasis. XIAP is found aberrantly expressed in cancer, which has been shown to promote resistance to therapy-induced apoptosis and confer poor outcome. Despite its predominant cytoplasmic localization in human tissues, growing evidence implicates the expression of XIAP in other subcell ...
DOI:
10.1016/j.bbadva.2022.100050

12. The dynamic nature of the coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia

Author:
Vincent J. Manna; Hana Choi; Shawna M. Rotoli; Salvatore J. Caradonna
Source:
BBA advances 2022 v.2 pp. 100044
ISSN:
2667-1603
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibodies; cell lines; computer software; epithelium; fluorescent antibody technique; humans; immunohistochemistry; liquid-air interface; models; nose; peptidyl-dipeptidase A; plasma membrane; protein isoforms; quantitative polymerase chain reaction; sequence analysis
Abstract:
... Once inhaled, SARS-CoV-2 particles enter respiratory ciliated cells by interacting with angiotensin converting enzyme 2 (ACE2). Understanding the nature of ACE2 within airway tissue has become a recent focus particularly in light of the COVID-19 pandemic. Airway mucociliary tissue was generated in-vitro using primary human nasal epithelial cells and the air-liquid interface (ALI) model of differen ...
DOI:
10.1016/j.bbadva.2022.100044

13. Application of zinc oxide nanoflowers in environmental and biomedical science

Author:
Victor Jeevan Raj; Rita Ghosh; Agnishwar Girigoswami; Koyeli Girigoswami
Source:
BBA advances 2022 v.2 pp. 100051
ISSN:
2667-1603
Subject:
air; biomarkers; biomedical research; biosensors; chemical reduction; cosmetics; energy; evaporation; nanoflowers; photocatalysis; pollutants; remediation; semiconductors; surface area; therapeutics; vapors; wastewater; zinc oxide
Abstract:
... Zinc oxide (ZnO) nanostructures can be synthesized in nanoforms of spheres, rods, flowers, disks, walls, etc., among which nanoflowers have gained special attention due to their versatile biomedical and pollutant remedial applications in waste water and air. ZnO nanoflowers have an ultrasmall size with a huge surface area to volume ratio due to their hexagonal petal structures which render them su ...
DOI:
10.1016/j.bbadva.2022.100051

14. C11orf21, a novel RUNX1 target gene, is down-regulated by RUNX1-ETO

Author:
Akifumi Matsumoto; Tatsushi Yoshida; Takahiro Shima; Kenta Yamasaki; Kenjiro Tadagaki; Noriko Kondo; Yasumichi Kuwahara; Dong-Er Zhang; Tsukasa Okuda
Source:
BBA advances 2022 v.2 pp. 100047
ISSN:
2667-1603
Subject:
chromosome translocation; computer simulation; consensus sequence; genes; humans; luciferase; myeloid leukemia; patients; promoter regions; site-directed mutagenesis; transcription (genetics); transcription factors
Abstract:
... The fusion protein RUNX1-ETO is an oncogenic transcription factor generated by t(8;21) chromosome translocation, which is found in FAB-M2-type acute myeloid leukemia (AML). RUNX1-ETO is known to dysregulate the normal RUNX1 transcriptional network, which should involve essential factors for the onset of AML with t(8;21). In this study, we screened for possible transcriptional targets of RUNX1 by r ...
DOI:
10.1016/j.bbadva.2022.100047

15. Does Microsecond Active-Site Dynamics Primarily control Proteolytic Activity of Bromelain? Clues from Single Molecular Level Study with a Denaturant, a Stabilizer and a Macromolecular Crowder

Author:
Nilimesh Das; Sandeep Yadav; Kuldeep Singh Negi; Ejaj Tarif; Pratik Sen
Source:
BBA advances 2022 v.2 pp. 100041
ISSN:
2667-1603
Subject:
active sites; bromelains; casein; cysteine; dyes; enzyme activity; proteolysis; spectroscopy; stabilizers; sucrose
Abstract:
... Proteins are dynamic entity with various molecular motions at different timescale and length scale. Molecular motions are crucial for the optimal function of an enzyme. It seems intuitive that these motions are crucial for optimal enzyme activity. However, it is not easy to directly correlate an enzyme's dynamics and activity due to biosystems' enormous complexity. amongst many factors, structure ...
DOI:
10.1016/j.bbadva.2022.100041

16. Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin

Author:
Shilpi Goenka
Source:
BBA advances 2022 v.2 pp. 100042
ISSN:
2667-1603
Subject:
Escherichia coli; humans; interleukin-6; lipopolysaccharides; melanin; melanocytes; secretion; serotypes
Abstract:
... Lipopolysaccharides (LPS) alter melanin synthesis and induce cytokine secretion in melanocytes; however, effects of different serotypes or species of LPS have been rarely addressed. Herein, LPS from serotypes (O55:B5, O26:B6, O128:B12) of E Coli and P gingivalis (LPS-PG) was examined in human melanocytes of lightly-pigmented (LP) and darkly-pigmented (DP) donors. Results showed no effect of any LP ...
DOI:
10.1016/j.bbadva.2022.100042

17. Increased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses

Author:
Graeme Benzie; Kristen Bouma; Taylor Battellino; Steven Cooper; Rick Hemming; Wafa Kammouni; Lin Liu; Cuong Do; Mazdak Khajehpour; Helene Perreault; Stuart Kornfeld; Barbara Triggs-Raine; Brian L. Mark
Source:
BBA advances 2022 v.2 pp. 100032
ISSN:
2667-1603
Subject:
death; enzyme replacement therapy; gangliosides; lysosomes; neurodegenerative diseases; neurons; phosphorylation
Abstract:
... Tay-Sachs and Sandhoff diseases are genetic disorders resulting from mutations in HEXA or HEXB, which code for the α- and β-subunits of the heterodimer β-hexosaminidase A (HexA), respectively. Loss of HexA activity results in the accumulation of GM2 ganglioside (GM2) in neuronal lysosomes, culminating in neurodegeneration and death, often by age 4. Previously, we combined critical features of the ...
DOI:
10.1016/j.bbadva.2021.100032

18. Regulation and functions of membrane lipids: Insights from Caenorhabditis elegans

Author:
Muhasin Koyiloth; Sathyanarayana N. Gummadi
Source:
BBA advances 2022 v.2 pp. 100043
ISSN:
2667-1603
Subject:
Caenorhabditis elegans; biosynthesis; cholesterol; diet; glycerophospholipids; homeostasis; humans; lipid bilayers; lipid composition; membrane fluidity; plasma membrane; sphingolipids
Abstract:
... The Caenorhabditis elegans plasma membrane is composed of glycerophospholipids and sphingolipids with a small cholesterol. The C. elegans obtain the majority of the membrane lipids by modifying fatty acids present in the bacterial diet. The metabolic pathways of membrane lipid biosynthesis are well conserved across the animal kingdom. In C. elegans CDP-DAG and Kennedy pathway produce glycerophosph ...
DOI:
10.1016/j.bbadva.2022.100043

19. A global analysis on the differential regulation of RNA binding proteins (RBPs) by TNF–α as potential modulators of metabolic syndromes

Author:
Jiss Maria Louis; Arjun Agarwal; Sukanta Mondal; Indrani Talukdar
Source:
BBA advances 2022 v.2 pp. 100037
ISSN:
2667-1603
Subject:
RNA; diabetes; heart; metabolic syndrome; necrosis; neoplasms; phosphorylation; phosphotransferases (kinases); risk; sequence analysis; stroke
Abstract:
... Metabolic syndrome (MetS) is associated with a group of conditions, which enhances the risk of diabetes, heart diseases and stroke in the affected individuals. Earlier reports from our lab have shown that Tumor necrosis factor-α (TNF-α) significantly modulates the expression of 56 genes at the alternative splicing level which are involved in various signaling and metabolic pathways (MetS genes) co ...
DOI:
10.1016/j.bbadva.2021.100037

20. A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissue

Author:
Gaewyn Ellison; Ashley L. Hollings; Mark J. Hackett
Source:
BBA advances 2022 v.2 pp. 100038
ISSN:
2667-1603
Subject:
astrocytes; brain; metallome; oligodendroglia; zinc
Abstract:
... It is now well established that transition metals, such as Iron (Fe), Copper (Cu), and Zinc (Zn) are necessary for healthy brain function. Although Fe, Cu, and Zn are essential to the brain, imbalances in the amount, distribution, or chemical form (“metallome”) of these metals is linked to the pathology of numerous brain diseases or disorders. Despite the known importance of metal ions for both br ...
DOI:
10.1016/j.bbadva.2021.100038