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1. Haploid yeast cells undergo a reversible phenotypic switch associated with chromosome II copy number

Author:
Drozdova, Polina; Mironova, Ludmila; Zhouravleva, Galina
Source:
BMC genetics 2016 v.17 no.Supplement 3 pp. 152
ISSN:
1471-2156
Subject:
chromosome elimination,   etc   ; chromosomes; essential genes; gene overexpression; genomics; guanidines; haploidy; mutants; mutation; phenotype; polypeptides; prions; translation (genetics); viability; yeasts;     Show all 15 Subjects
Abstract:
... BACKGROUND: SUP35 and SUP45 are essential genes encoding polypeptide chain release factors. However, mutants for these genes may be viable but display pleiotropic phenotypes which include, but are not limited to, nonsense suppressor phenotype due to translation termination defect. [PSI ⁺] prion formation is another Sup35p-associated mechanism leading to nonsense suppression through decreased avail ...
DOI:
10.1186/s12863-016-0464-4
PubMed:
28105933
PubMed Central:
PMC5249023