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- Vicient, Carlos M, et al. Show all 2 Author
- BMC plant biology 2013 v.13 no.1 pp. 186
- DNA damage; DNA topoisomerase; alkaloids; cell growth; corn; cultured cells; enzyme activity; mass spectrometry; nucleases; pH; single-stranded DNA; two-dimensional gel electrophoresis; zinc
- ... BACKGROUND: Camptothecin is a plant alkaloid that specifically binds topoisomerase I, inhibiting its activity and inducing double stranded breaks in DNA and activating the cell responses to DNA damage. RESULTS: Maize cultured cells were incubated in the presence of different concentrations of camptothecin. Camptothecin inhibits cultured cell growth, induces genomic DNA degradation, and induces a 3 ...
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