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1. Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation

Author:
Keller, Janine,   et al.   ; Schlegel, Gloria; Hirche, Frank; Geißler, Stefanie; Schwarz, Frieder J; Ringseis, Robert; Stangl, Gabriele I; Eder, Klaus;     Show all 8 Authors
Source:
BMC veterinary research 2012 v.8 no.1 pp. 356
ISSN:
1746-6148
Subject:
biopsy; biosynthesis; carnitine; cations; dairy cows; early lactation; energy balance; energy deprivation; enzymes; fatty acid composition; fatty acids; free fatty acids; gene expression; gene targeting; genes; hepatocytes; liver; messenger RNA; oxidation; pregnancy; receptors; rodents; swine; transcription factors; transporters
Abstract:
... BACKGROUND: In rodents and pigs, it has shown that carnitine synthesis and uptake of carnitine into cells are regulated by peroxisome proliferator-activated receptor α (PPARA), a transcription factor which is physiologically activated during fasting or energy deprivation. Dairy cows are typically in a negative energy balance during early lactation. We investigated the hypothesis that genes of carn ...
DOI:
10.1186/1746-6148-8-28
PubMed:
22417075
PubMed Central:
PMC3361467