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You searched for: Journal name Biochemical and biophysical research communications Remove constraint Journal name: Biochemical and biophysical research communications Publication year rev 7978-2022 Remove constraint Publication year rev: 7978-2022 Source 2022 v.622 Remove constraint Source: 2022 v.622
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1. 7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis

Author:
Weitao Zhang; Hanyue Xue; Chen Zhou; Zuguo Zheng; Mingming Xing; Hang Chu; Ping Li; Naixia Zhang; Yongjun Dang; Xiaojun Xu
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 184-191
ISSN:
0006-291X
Subject:
adipose tissue; antibiotics; blood serum; cholesterol; fatty liver; heat-shock protein 90; liver; microarray technology; research; triacylglycerols
Abstract:
... Hepatic steatosis is one of the most important causes of liver disease worldwide. Heat shock protein 90 (HSP90) is essential for numerous client proteins. Recently, more attention was focused on increased HSP90 levels in hepatic steatosis, especially HSP90β. Thus, great efforts have been made to develop HSP90β inhibitors, and most natural inhibitors are derived from microorganisms. In this study, ...
DOI:
10.1016/j.bbrc.2022.07.033

2. Amentoflavone impairs the reconsolidated fear memories through inhibition of ERK pathway

Author:
Kuisheng Sun; Ruizhu Xie; Zhengjun Yi; Liqian Yin; Yan Guan; Lujuan Wang; Ying Wang; Xiaoyan Ding; Yaning Luan; Huijie Liu; Yuhan Fan
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 8-14
ISSN:
0006-291X
Subject:
Western blotting; amygdala; animal behavior; fearfulness; inflammation; memory; pathophysiology; research
Abstract:
... Post-traumatic stress disorder (PTSD) is a pathological fear memory-related disease. The persistence of pathological fearful memories is one of the most characteristic symptoms of PTSD. However, this can be eliminated by intervening in reconsolidation. Inflammation is intimately involved in the pathophysiologic progression of PTSD. Amentoflavone (AF) has anti-inflammatory effects. However, the eff ...
DOI:
10.1016/j.bbrc.2022.07.024

3. Combinatorial transcriptional regulation of HEB/ZEB1/ASCL1 and MYBL2 on Ras/ErbB signaling

Author:
Feiliang Zhong; Tingting Chen; Bo Li
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 170-176
ISSN:
0006-291X
Subject:
breast neoplasms; carcinogenesis; cell cycle; chromatin immunoprecipitation; liver neoplasms; loci; lung neoplasms; melanoma; oncogenes; patients; research; transcription (genetics); transcription factors
Abstract:
... Gene expression is tightly regulated by transcription factors (TFs) which play an important role in development and tumorigenesis. Abnormal transcriptional regulation leads to oncogene activation or tumor suppressor inhibition, thus promoting the occurrence and progression of tumors. MYBL2 (alias B-Myb), a ubiquitously expressed transcription factor of the MYB family, is a nuclear protein involved ...
DOI:
10.1016/j.bbrc.2022.07.046

4. Culturable bacteria in the entire acne lesion and short-chain fatty acid metabolites of Cutibacterium acnes and Staphylococcus epidermidis isolates

Author:
Tristan Yusho Huang; Yong E. Jiang; David A. Scott
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 45-49
ISSN:
0006-291X
Subject:
Acinetobacter; Pseudomonas; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus hominis; acetates; acne; agar; butyrates; fermentation; gas chromatography-mass spectrometry; metabolites; microbiome; probiotics; propionic acid; research; short chain fatty acids
Abstract:
... Although evidence supports that the acne microbiome harbors a diverse range of microbes that play a vital role in the progression of acne vulgaris, the culturable microbes in the acne microbiome have not yet been largely identified. Here, we grew microbe colonies from entire acne lesions on agar plates and identified abundant Staphylococcus, Acinetobacter, and Pseudomonas species from forty select ...
DOI:
10.1016/j.bbrc.2022.06.068

5. Effect of bacteriophage-encoded chaperonins on amyloid transformation of α-synuclein

Author:
Evgeniia V. Leisi; Kseniya V. Barinova; Sofia S. Kudryavtseva; Andrey V. Moiseenko; Vladimir I. Muronetz; Lidia P. Kurochkina
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 136-142
ISSN:
0006-291X
Subject:
adenosinetriphosphatase; amyloid; bacteriophages; chaperonins; encapsulation; research
Abstract:
... Controversial information about the role of chaperonins in the amyloid transformation of proteins and, in particular, α-synuclein, requires a more detailed study of the observed effects due to the structure and functional state of various chaperonins. In this work, two types of phage chaperonins, the double-ring EL and the single-ring OBP, were shown to stimulate α-synuclein fibrillation in an ATP ...
DOI:
10.1016/j.bbrc.2022.07.015

6. Effects of chemically EGFR targeting on non-targeted physical cell behaviors in 2D and 3D microfluidic cultures of invasive and non-invasive breast cancer cell lines

Author:
Shohreh Azadi; Ehsan Mohammadi; Mohammad Tafazzoli-Shadpour; Mohammad Tabatabaei
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 1-7
ISSN:
0006-291X
Subject:
actin; antineoplastic agents; biomarkers; breast neoplasms; carcinogenesis; cell viability; chemical treatment; collagen; cytoskeleton; drug therapy; myosin; neoplasm cells; research; vimentin
Abstract:
... Cancer development comprehends changes in cell structural and physical states. Cancer cells are softer than normal cells, produce higher contractile forces, and migrate more easily. While chemotherapy, targets proteins involved in biological behaviors, it may affect cell physicomechanical state due to the interconnections among signaling pathways. Here we treated non-invasive and invasive breast c ...
DOI:
10.1016/j.bbrc.2022.07.013

7. Immunization with 674–685 fragment of SARS-Cov-2 spike protein induces neuroinflammation and impairs episodic memory of mice

Author:
Olena Lykhmus; Olena Kalashnyk; Lyudmyla Koval; Olga Krynina; Serhiy Komisarenko; Maryna Skok
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 57-63
ISSN:
0006-291X
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; acetylcholine; blood; brain; choline; cognition; decline; hemocyanin; immune response; immunization; immunoglobulins; memory; memory disorders; nicotinic receptors; research
Abstract:
... COVID-19 is accompanied by strong inflammatory reaction and is often followed by long-term cognitive disorders. The fragment 674–685 of SARS-Cov-2 spike protein was shown to interact with α7 nicotinic acetylcholine receptor involved in regulating both inflammatory reactions and cognitive functions. Here we show that mice immunized with the peptide corresponding to 674–685 fragment of SARS-Cov-2 sp ...
DOI:
10.1016/j.bbrc.2022.07.016

8. Mutations in the polyhedrin NLS affect the assembly and polyhedral shape of alphabaculovirus occlusion bodies

Author:
Susumu Katsuma
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 15-21
ISSN:
0006-291X
Subject:
Autographa californica multiple nucleopolyhedrovirus; Bombyx mori nucleopolyhedrovirus; arginine; mutation; nuclear localization signals; research
Abstract:
... Alphabaculoviruses produce occlusion bodies (OBs) in the nucleus of the infected cells at the late stage of infection. OBs are mainly composed of a single viral protein called polyhedrin (POLH). Autographa californica multiple nucleopolyhedrovirus (AcMNPV) POLH possesses a monopartite nuclear localization signal sequence (NLS), KRKK, from 32nd to 35th residues. However, the functions of POLH NLS o ...
DOI:
10.1016/j.bbrc.2022.07.023

9. Reversible acetylation modulates p54nrb/NONO-mediated expression of the interleukin 8 gene

Author:
Jae-Eun Ryu; Taek-Yeol Jung; Seong-Hoon Park; Jun Hong Park; Hyun-Seok Kim
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 50-56
ISSN:
0006-291X
Subject:
DNA repair; acetylation; acetyltransferases; genes; interleukin-8; lysine; methylation; phosphorylation; research; sirtuins; transcription (genetics)
Abstract:
... The non-POU domain-containing octamer-binding protein (NONO, also referred to as p54nrb) is a multifunctional nuclear protein engaging in transcriptional regulation, mRNA splicing, nuclear retention of defective RNA, and DNA repair. Emerging evidence has demonstrated that p54nrb is subjected to various posttranslational modifications, including phosphorylation and methylation, which may be importa ...
DOI:
10.1016/j.bbrc.2022.06.085

10. Rheology predicts sputum eosinophilia in patients with muco-obstructive lung diseases

Author:
Mathilde Volpato; Jerome Vialaret; Christophe Hirtz; Aurélie Petit; Carey Suehs; Jérémy Patarin; Eric Matzner-Lober; Isabelle Vachier; Nicolas Molinari; Arnaud Bourdin; Jeremy Charriot
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 64-71
ISSN:
0006-291X
Subject:
Internet; asthma; cell biology; cohort studies; eosinophilia; gene amplification; lungs; mass spectrometry; modulus of elasticity; mucins; mucus; protein content; research; rheology; rheometers
Abstract:
... Mucus is known to play a pathogenic role in muco-obstructive lung diseases, but little is known about the determinants of mucus rheology. The purpose of this study is to determine which sputum components influence sputum rheology in patients with muco-obstructive lung diseases. We performed a cross sectional prospective cohort study. Spontaneous sputum was collected from consecutive patients with ...
DOI:
10.1016/j.bbrc.2022.07.025

11. Study of the influence of hyperglycemia on the abundance of amino acids, fatty acids, and selected lipids in extracellular vesicles using TOF-SIMS

Author:
Magdalena E. Marzec; Carina Rząca; Paweł Moskal; Ewa Ł. Stępień
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 30-36
ISSN:
0006-291X
Subject:
cholesterol; exosomes; glucose; humans; hyperglycemia; isoleucine; liquids; mass spectrometry; phenylalanine; research; tyrosine; valine
Abstract:
... Time-of-flight secondary ion mass spectrometry (TOF-SIMS) with the Bi₃⁺ liquid metal ion gun was used to investigate the content of lipids and amino acids (AAs) in extracellular vesicles (EVs). We induced metabolic changes in human pancreatic β-cells by stimulation with high glucose concentrations (35 mM) and tested the hypothesis of hyperglycemia (HG) has a detrimental effect on lipids and AAs in ...
DOI:
10.1016/j.bbrc.2022.07.020

12. Using adenovirus-mediated gene transfer to study the effect of myeloperoxidase on plasma lipid levels, HDL structure and functionality in mice expressing human apoA-I forms

Author:
Katerina Dalakoura-Karagkouni; Ioanna Tiniakou; Vassilis I. Zannis; Dimitris Kardassis
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 108-114
ISSN:
0006-291X
Subject:
amino acids; antioxidants; apolipoprotein A-I; atherosclerosis; biogenesis; blood lipids; catabolism; cholesterol; electrophoresis; gene transfer; high density lipoprotein; humans; inflammation; liver; macrophages; mutation; myeloperoxidase; peroxidase; research; toxicity
Abstract:
... Apolipoprotein A-I (apoA-I), the main protein component of High-Density Lipoprotein (HDL), is modified in plasma and the arterial wall by various enzymes. Myeloperoxidase (MPO), a leukocyte-derived peroxidase, is highly expressed during inflammation and associates with HDL reducing its functionality and contributing to atherosclerosis. In the present study we sought to explore further the effect o ...
DOI:
10.1016/j.bbrc.2022.07.001

13. ZFP64 transcriptionally activates PD-1 and CTLA-4 and plays an oncogenic role in esophageal cancer

Author:
Gan Qiu; Yiping Deng
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 72-78
ISSN:
0006-291X
Subject:
apoptosis; bioinformatics; carcinogenesis; cell proliferation; esophageal neoplasms; gain-of-function mutation; immunohistochemistry; mice; neoplasm cells; protein synthesis; research; transcription (genetics); transcription factors; xenotransplantation; zinc finger motif
Abstract:
... Anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death-1 (PD-1) are promising therapies for esophageal cancer. Zinc finger protein 64 (ZFP64) is precited as a transcriptional factor for PD-1 and CTLA-4 and presents high expression in esophagus cancer by bioinformatics analysis. The present study was designed to validate these results and to further explore the role of ...
DOI:
10.1016/j.bbrc.2022.06.011

14. The mouse homolog of the mutant WASp responsible for human X-linked neutropenia renders granulopoiesis ineffective

Author:
Masahiro Ikeda; Muneyoshi Futami; Bidisha Chanda; Masayuki Kobayashi; Kiyoko Izawa; Arinobu Tojo
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 177-183
ISSN:
0006-291X
Subject:
actin; bone marrow; gain-of-function mutation; genes; hematopoiesis; humans; mice; mutants; neutropenia; neutrophils; polymerization; research
Abstract:
... Severe congenital neutropenia (SCN) is characterized by severe neutropenia and recurrent critical infections. X-linked neutropenia (XLN) is caused by a gain-of-function mutation in the Wiskott-Aldrich syndrome gene (WAS), the product of which (WASp) is expressed only in blood cells, especially during neutrophil maturation. To investigate the mechanism of neutropenia, we established a novel knock-i ...
DOI:
10.1016/j.bbrc.2022.07.037

15. Crystal structures of the catalytic domain of human PARP15 in complex with small molecule inhibitors

Author:
Xuelan Zhou; Yang Yang; Qin Xu; Huan Zhou; Fanglin Zhong; Jun Deng; Jin Zhang; Jian Li
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 93-100
ISSN:
0006-291X
Subject:
DNA repair; active sites; drugs; enzymes; humans; ligands; research; therapeutics
Abstract:
... PARP15, or ARTD7, is an enzyme carrying out mono-ADP-ribosylation and regulating activities of a range of cellular proteins. This enzyme belongs to the family of the poly(ADP-ribose) polymerases (PARPs), which comprises of proteins with various potential disease indications. Due to their involvement in a number of cellular processes and important role in DNA repair and regulation, PARPs have been ...
DOI:
10.1016/j.bbrc.2022.06.070

16. Discovery of glycosylated naphthacemycins and elucidation of the glycosylation

Author:
Yu-Hang Gao; Qiu-Yue Nie; Yu Hu; Xinhua Lu; Wensheng Xiang; Xiangjing Wang; Gong-Li Tang
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 122-128
ISSN:
0006-291X
Subject:
Streptomyces; biocatalysts; biosynthesis; glucose; glycosylation; multigene family; research; solubility
Abstract:
... Two glycosylated naphthacemycins (naphthacemycins D₁ and D₂) were identified in Streptomyces sp. N12W1565. These two compounds not only showed antimicrobial potential against bacteria but also exhibited more aqueous solubility than naphthacemycins. Furthermore, the whole genome of Streptomyces sp. N12W1565 has been sequenced, the natY gene, located outside the biosynthetic gene cluster encoding a ...
DOI:
10.1016/j.bbrc.2022.06.095

17. ERK1 loss accelerates the progression of osteoarthritis in aged mice via NRF2/BACH1 signaling

Author:
Jian Chen; Zhijun Chen; Putao Yuan; Hai Huang; Jiying Wang; Peihua Shi; Xuewu Sun
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 129-135
ISSN:
0006-291X
Subject:
cartilage; chondrocytes; dimethyl fumarate; mitogen-activated protein kinase; osteoarthritis; research; therapeutics; transportation
Abstract:
... Osteoarthritis (OA) is now a common degenerative joint related disease. However, the clinical efficacy of drugs associated with cartilage regeneration remains limited. In our study, we firstly explored the role of ERK1 in the progression of OA. We clarified that ERK1-deficient mice were susceptible to age-related OA. The higher OARSI scores and more severe cartilage degeneration was observed in th ...
DOI:
10.1016/j.bbrc.2022.07.012

18. Effect of chemically induced osteogenesis supplements on multicellular behavior of osteocytic spheroids

Author:
Jeonghyun Kim; Takashi Inagaki; Junko Sunaga; Taiji Adachi; Takeo Matsumoto
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 79-85
ISSN:
0006-291X
Subject:
actin; bone formation; collagen; models; morphogenesis; organoids; research
Abstract:
... Understanding in multicellular behaviors in three-dimensional (3D) culture models such as organoids is important to help us better comprehend the mechanisms of the morphogenesis and functions of diverse organs in vivo cellular environment. In this study, we elucidated the multicellular behaviors of the osteocytic spheroids in response to the chemically induced osteogenesis supplements (OS). Partic ...
DOI:
10.1016/j.bbrc.2022.07.026

19. Exosomes from bone marrow mesenchymal stem cells decrease chemosensitivity of acute myeloid leukemia cells via delivering miR-10a

Author:
Juan Wu; Yaqin Zhang; Xiaoyu Li; Jingyi Ren; Ling Chen; Jiadi Chen; Yingping Cao
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 149-156
ISSN:
0006-291X
Subject:
bone marrow; coculture; exosomes; myeloid leukemia; research
Abstract:
... Bone marrow mesenchymal stem cells (BMSCs) are an integral part of the acute myeloid leukemia (AML) bone marrow microenvironment and contribute to AML progression. In this study, we explored the communication between BMSCs and AML cells via exosomes. The AML cells co-cultured with BMSCs-Exos were found to have lower chemosensitivity exposed to cytarabine, suggesting that BMSCs-Exos could protect A ...
DOI:
10.1016/j.bbrc.2022.07.017

20. Fluorescence imaging of epigenetic genome modifications

Author:
Maria A. Moshareva; Konstantin A. Lukyanov; Lidia V. Putlyaeva
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 86-92
ISSN:
0006-291X
Subject:
5-methylcytosine; DNA; epigenetics; epigenome; fluorescence; histones; research
Abstract:
... Epigenome contains a lot of information about cell state. Epigenetic analysis includes primarily sequence-based methods, which provide detailed data on distribution of modifications along the genome, but are poorly applicable for screenings. Specific fluorescence labeling and imaging of epigenetic modifications is an attractive complementary approach. It is currently based mainly on histone modifi ...
DOI:
10.1016/j.bbrc.2022.07.014