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Biochemical and biophysical research communications
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Publication year rev
7978-2022
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2022 v.632
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- Author:
- Jae-Byoung Chae; Chul-Woo Park; Hyeong Min Lee; Leo Sungwong Choi; Chaehee Park; Junghoon Kim; Jaejin Shin; Jooseung Hyeon; Jihan Lee; Hyungwoo Lee; Hyung Soon Park; Chang-Hoon Nam; Hyewon Chung
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 62-68
- ISSN:
- 0006-291X
- Subject:
- DNA damage; RNA; adults; apoptosis; blood vessels; cell cycle checkpoints; cell senescence; epithelium; inflammation; macular degeneration; mice; models; pathogenesis; research; retina; vision
- Abstract:
- ... Age-related macular degeneration (AMD) is a chronic and progressive disease characterized by degeneration of the retinal pigment epithelium (RPE) and retina that ultimately leads to loss of vision. The pathological mechanisms of AMD are not fully known. Cellular senescence, which is a state of cell cycle arrest induced by DNA-damage or aging, is hypothesized to critically affect the pathogenesis o ...
- DOI:
- 10.1016/j.bbrc.2022.09.061
- https://doi.org/10.1016/j.bbrc.2022.09.061
- Author:
- Jian Yang; Yongzheng Li; Zhaowei Sun; Zhiyao Fan; Ming Shi; Shujie Liu; Yufan Meng; Bin Zhou; Yuanyuan Jiang; Hanxiang Zhan
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 1-9
- ISSN:
- 0006-291X
- Subject:
- bioinformatics; cell proliferation; data collection; gene expression; gene expression regulation; genome; neoplasm progression; pancreatic neoplasms; prognosis; protein-protein interactions; quantitative polymerase chain reaction; regression analysis; research; sequence analysis
- Abstract:
- ... This study aimed to determine the role of COL17A1 in tumor progression and predict the prognosis of pancreatic cancer (PC). RNA-seq data from The Cancer Genome Atlas and Genotype-Tissue Expression were analyzed using bioinformatics methods. “Limma” package was used to screen differentially expressed genes (DEGs). Prognostic-associated data were further analyzed using univariate Cox regression and ...
- DOI:
- 10.1016/j.bbrc.2022.09.049
- https://doi.org/10.1016/j.bbrc.2022.09.049
- Author:
- Takashi Kurita; Xiaoyan Li; Ujjal K. Bhawal
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 32-39
- ISSN:
- 0006-291X
- Subject:
- alkaline phosphatase; bioinformatics; bone formation; femur; gain-of-function mutation; genes; histopathology; humans; immunohistochemistry; mice; micro-computed tomography; microRNA; osteoblasts; osteopontin; research; toluidine blue; transcription factors; transfection
- Abstract:
- ... MicroRNAs are associated with pivotal post-transcriptional gene regulation in bone formation. Human differentiated embryonic chondrocyte expressed gene 1 (Dec1) is also involved in regulating osteoblastogenesis. In the present study, we aimed to investigate the distinctive role of miR-21–5p and Dec1 in osteoblast function and to determine their biological functions. MC3T3-E1 pre-osteoblastic cells ...
- DOI:
- 10.1016/j.bbrc.2022.09.090
- https://doi.org/10.1016/j.bbrc.2022.09.090
- Author:
- Da-Som Kim; Wonjun Ji; Dong Ha Kim; Yun Jung Choi; Kyungtaek Im; Chae Won Lee; Jeongin Cho; Joongkee Min; Dong-Cheol Woo; Chang-Min Choi; Jae Cheol Lee; Young Hoon Sung; Jin Kyung Rho
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 85-91
- ISSN:
- 0006-291X
- Subject:
- adults; animal models; carcinogenesis; drug development; drug resistance; drugs; epidermal growth factor receptors; genetic engineering; genetically modified organisms; humans; luciferase; lung neoplasms; magnetism; mice; mutants; oncogenes; research; transgenes
- Abstract:
- ... Although epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) have shown dramatic response and improvement in treating lung cancer with mutant EGFR, the emergence of drug resistance remains a major problem. In particular, some mutations including T790 M and C797S have been recognized as mechanisms of acquired resistance because they weaken binding affinity to drugs. To date, m ...
- DOI:
- 10.1016/j.bbrc.2022.09.104
- https://doi.org/10.1016/j.bbrc.2022.09.104
- Author:
- Qi Guo; Lijia Zhang; Lei Zhao; Xueying Pang; Peng Wang; Heng Sun; Songjiang Liu
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 48-54
- ISSN:
- 0006-291X
- Subject:
- RNA; bioinformatics; cytoplasm; gain-of-function mutation; genes; migratory behavior; neoplasm cells; research; therapeutics; uterine cervical neoplasms
- Abstract:
- ... Cervical cancer (CC) is the second most common malignancy among women. GEPIA demonstrated that MEF2C-AS1 and its nearby gene MEF2C present downregulation in CC tissues. We attempted to clarify molecular mechanism between MEF2C-AS1 and MEF2C underlying CC progression. RT-qPCR was used to measure expression levels and subcellular distribution of MEF2C-AS1 and MEF2C in CC cell lines. Gain-of-function ...
- DOI:
- 10.1016/j.bbrc.2022.09.091
- https://doi.org/10.1016/j.bbrc.2022.09.091
- Author:
- Hai Zhou; Jing Zhou; Hongwei Teng; Hua Yang; Jinsong Qiu; Xiangdong Li
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 92-99
- ISSN:
- 0006-291X
- Subject:
- animal models; apoptosis; bone marrow; brain; brain damage; cell communication; cell cycle checkpoints; exosomes; infarction; ischemia; microRNA; neuroglia; oxidative stress; phenotype; research; stroke
- Abstract:
- ... Mesenchymal stem cells-derived exosomes (MSCs-Exo) were able to exert neuroprotective effects in brain injury after ischemic stroke (IS). In addition, exosomes containing microRNAs (miRNAs) can be transported to recipient cells to mediate intercellular communication. It has been shown that the level of miR-145 was significantly downregulated in brain tissues of rats subjected to middle cerebral ar ...
- DOI:
- 10.1016/j.bbrc.2022.09.089
- https://doi.org/10.1016/j.bbrc.2022.09.089
- Author:
- Shen Zhang; Jian Ding; Yanni Tu; Qiuyu Zhang; Zheng Ye; Hao Yu; Qingyan Sun; Tianmiao Hua
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 17-23
- ISSN:
- 0006-291X
- Subject:
- calcium-calmodulin-dependent protein kinase; cortex; glutamic acid; membrane proteins; neurons; phosphorylation; plasma membrane; protein content; research; visual cortex; visual perception
- Abstract:
- ... Numerous studies indicate that top-down influence plays critical roles in visual perception by enhancing neuronal excitability in the primary visual cortex (V1). The underlying mechanisms are poorly understood. This study examined changes of excitatory glutamatergic markers in the V1 cortex of cat after top-down influence of cortical area 7 (A7) was modulated by transcranial direct current stimula ...
- DOI:
- 10.1016/j.bbrc.2022.09.082
- https://doi.org/10.1016/j.bbrc.2022.09.082
- Author:
- Fei Lu; Pengfei Liang; Bei Fan; Qingwen Zhu; Tao Xue; Zhenzhen Liu; Renfeng Wang; Yukai Zhang; Xinyu Zhang; Wei Li; Shujuan Wang; Jun Chen; Dingjun Zha
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 69-75
- ISSN:
- 0006-291X
- Subject:
- cytoplasm; deafness; etiology; fluorescent antibody technique; ganglia; genes; heterozygosity; homozygosity; mice; neurons; pedigree; peripheral nervous system diseases; research
- Abstract:
- ... Autosomal recessive nonsyndromic auditory neuropathy is attributed to a genetic etiology. We identified a compound heterozygous missense variant, c.G736A (p.G246S) and c.C2954T (p.T985 M) in TNN of affected patients in a pedigree via candidate gene screening and exome sequencing. To determine the genetic etiology of deafness in the pedigree with a heterozygous missense variant in the gene TNN enco ...
- DOI:
- 10.1016/j.bbrc.2022.09.081
- https://doi.org/10.1016/j.bbrc.2022.09.081
- Author:
- Yan Zhang; Li Zhang; Birui Shi; Fulong Huang; Yinhuang Gao; Zhishuo Miao; Ke Ma; Ziyao Zhan; Wei Zou; Menghua Liu
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 24-31
- ISSN:
- 0006-291X
- Subject:
- Bacteroidetes; Firmicutes; Proteobacteria; corticotropin; drug development; forced swimming test; gene expression; hormone receptors; intestinal microorganisms; mental health; mice; models; pathogenesis; physiology; research; serotonin; sucrose; tail suspension test
- Abstract:
- ... Postpartum depression (PPD) is a serious mental health concern of new mothers worldwide. In view of the particularity of puerpera, the research on pathogenesis and drug development of PPD are highly dependent on animal models. Although both maternal separation (MS) and chronic unpredictable mild stress (CUMS) modeling approaches have been used in PPD studies, the characteristics of the two rodent ...
- DOI:
- 10.1016/j.bbrc.2022.09.063
- https://doi.org/10.1016/j.bbrc.2022.09.063
- Author:
- I-Hsun Huang; Shin-Ichiro Miyashita; Tsuyoshi Hata; Shura Karatsu; Keita Hosoya; Yoshimasa Sagane
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 55-61
- ISSN:
- 0006-291X
- Subject:
- Clostridium botulinum; botulinum toxin; cell death; cell lines; cell viability; cytotoxicity; epithelial cells; hemagglutinins; intestines; kidneys; models; neurotoxins; rats; research; serotypes
- Abstract:
- ... Clostridium botulinum produces seven botulinum neurotoxin (BoNT) serotypes. In nature, BoNT exists as a part of the progenitor toxin complex (PTC) through associations with neurotoxin associated proteins (NAPs), including nontoxic nonhemagglutinin and hemagglutinin (HA) complex, consists of HA-70, HA-17 and HA-33. Because PTC displays higher oral toxicity than pure BoNTs, NAPs play a critical role ...
- DOI:
- 10.1016/j.bbrc.2022.09.093
- https://doi.org/10.1016/j.bbrc.2022.09.093
- Author:
- Fumitaka Hiura; Yuko Kawabata; Tsukasa Aoki; Akiko Mizokami; Eijiro Jimi
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 40-47
- ISSN:
- 0006-291X
- Subject:
- actin; autophagosomes; autophagy; bone formation; bone marrow; bone resorption; dose response; genes; ligands; macrophages; males; mice; models; osteoclasts; periodontitis; phosphatidylethanolamines; research; silk; therapeutics
- Abstract:
- ... Autophagy is a non-selective action in which cells degrade parts of themselves, reusing degraded cellular components. Among autophagy-related gene (ATG) family members, ATG4 proteins play crucial roles in the microtubule-associated protein 1 light chain 3 (LC3) phosphatidylethanolamine (PE) system which is essential for autophagosome maturation. Although autophagy has been shown to be involved in ...
- DOI:
- 10.1016/j.bbrc.2022.09.065
- https://doi.org/10.1016/j.bbrc.2022.09.065
- Author:
- Di Zhou; Qiaohui Yang; Jialin Li; Xiao Liu; Jin Li; Wang Zhou; Yujiao Chai; Zhuo Li
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 76-84
- ISSN:
- 0006-291X
- Subject:
- cell structures; epithelium; hematopoiesis; humans; muscle development; neurogenesis; research; retina; sequence analysis; sex determination; wnt proteins
- Abstract:
- ... Hairy and enhancer of split homolog-1 (Hes1) is a member of an extensive family of basic helix-loop-helix (bHLH) proteins and plays a crucial role in neurogenesis, myogenesis, hematopoiesis, and sex determination. It has been reported that Hes1 is essential for precursors maintenance, optic cup-stalk boundary maintenance, and morphogenesis of the retina. However, it still reminds questions about t ...
- DOI:
- 10.1016/j.bbrc.2022.09.080
- https://doi.org/10.1016/j.bbrc.2022.09.080
- Author:
- Yangming Zhang; Yuqiao Xie; Zishuo Cheng; Kaiwen Xi; Xin Huang; Fang Kuang; Wenting Wang; Tiaotiao Liu; Baolin Guo; Shengxi Wu
- Source:
- Biochemical and biophysical research communications 2022 v.632 pp. 10-16
- ISSN:
- 0006-291X
- Subject:
- Toll-like receptor 4; animal models; dose response; electroencephalography; hippocampus; memory; memory disorders; mice; neuroglia; quercetin; research; sleep deprivation; therapeutics
- Abstract:
- ... Paradoxical sleep deprivation (PSD) is prevalent in modern society, and impaired memory is one of its serious consequences. The pathogenic mechanism is still unclear, and the therapeutic strategies for PSD are limited. Here, we found that quercetin treatment ameliorated memory impairments caused by PSD in a dose-dependent manner in an animal model. Quercetin could restore the dynamic changes of th ...
- DOI:
- 10.1016/j.bbrc.2022.09.088
- https://doi.org/10.1016/j.bbrc.2022.09.088