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You searched for: Journal name Biochemical and biophysical research communications Remove constraint Journal name: Biochemical and biophysical research communications Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Source 2019 v.514 no.1 Remove constraint Source: 2019 v.514 no.1
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1. ALOX12 inhibition sensitizes breast cancer to chemotherapy via AMPK activation and inhibition of lipid synthesis

Author:
Zhen Huang; Longjie Xia; Xiao Zhou; Changyuan Wei; Qinguo Mo
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 24-30
ISSN:
0006-291X
Subject:
AMP-activated protein kinase; acetyl coenzyme A; apoptosis; arachidonic acid; breast neoplasms; breasts; cell lines; drug therapy; enzyme activity; gain-of-function mutation; messenger RNA; metabolites; neoplasm cells; patients; protein content; tissues
Abstract:
... Arachidonate lipoxygenase12 (Alox12) and its metabolites 12S-hydroxyeicosatetraenoic acid (12S-HETE) have been implicated in influencing tumor transformation and progression. In this study, we have systematically evaluated the expression, function and the downstream effectors of Alox12 in breast cancer using loss- and gain-of-function approaches. We demonstrated that both mRNA and protein levels o ...
DOI:
10.1016/j.bbrc.2019.04.101

2. ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation

Author:
Shintaro Watanuki; Hiroshi Kobayashi; Yuriko Sorimachi; Masamichi Yamamoto; Shinichiro Okamoto; Keiyo Takubo
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 287-294
ISSN:
0006-291X
Subject:
adenosine triphosphate; bone marrow; cell cycle; cell differentiation; glucose; glycolysis; hematopoietic stem cells; monitoring; monocytes; nutrient requirements; oxidative phosphorylation
Abstract:
... Hematopoietic stem cells (HSCs) are quiescent cells in the bone marrow niche and are relatively dependent on glycolytic ATP production. On the other hand, differentiated cells, including hematopoietic progenitor cells (HPCs), preferentially generate ATP via oxidative phosphorylation. However, it is unclear how cellular differentiation and the cell cycle status affect nutritional requirements and A ...
DOI:
10.1016/j.bbrc.2019.04.123

3. Adiponectin alleviates NLRP3-inflammasome-mediated pyroptosis of aortic endothelial cells by inhibiting FoxO4 in arteriosclerosis

Author:
Liwei Zhang; Ming Yuan; Liang Zhang; Bin Wu; Xiao Sun
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 266-272
ISSN:
0006-291X
Subject:
Western blotting; adiponectin; atherosclerosis; caspase-1; cell viability; endothelial cells; epithelial cells; humans; inflammasomes; interleukin-18; interleukin-1beta; lactate dehydrogenase; lipopolysaccharides; oxidation; pyroptosis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; secretion; small interfering RNA; therapeutics
Abstract:
... Endothelial dysfunctions, such as pyroptosis, are chronic inflammatory processes with important roles in atherosclerosis. Adiponectin (APN), an adipocyte-derived protein that is abundant in circulation, reportedly protects against atherosclerosis. However, the mechanism underlying its antiatherogenic effect on human aortic epithelial cells remains unknown. In this study, oxidized lipopolysaccharid ...
DOI:
10.1016/j.bbrc.2019.04.143

4. Anxiety and task performance changes in an aging mouse model

Author:
Erika D. Nolte; Keith A. Nolte; Shirley ShiDu Yan
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 246-251
ISSN:
0006-291X
Subject:
animal behavior; animal models; anxiety; cognition; cognitive disorders; females; males; mice; risk factors; senescence (aging)
Abstract:
... Due to the increasing focus on aging as an important risk factor for many serious diseases and an emphasis on animal models that have translational value, an increasing number of animal models are being aged. Animal behavior tests can be used to assess effects of aging in mouse models. Female mice begin exhibiting anxiety-like behaviors at 12 months of age which become more serious at 24 months, w ...
DOI:
10.1016/j.bbrc.2019.04.049

5. Aryl hydrocarbon receptor activation alleviates dextran sodium sulfate-induced colitis through enhancing the differentiation of goblet cells

Author:
Jiuheng Yin; Kunqiu Yang; Chao Zhou; Pengyuan Xu; Weidong Xiao; Hua Yang
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 180-186
ISSN:
0006-291X
Subject:
bacteria; colitis; cytokines; dextran; goblet cells; human cell lines; immunohistochemistry; inflammation; intestines; mice; microbial load; models; signal transduction
Abstract:
... The intestinal inflammation induces disruption of the intestinal barrier function and leads to bacteria invasion. Accumulating evidences revealed that the aryl hydrocarbon receptor (AhR) plays a vital role in maintaining the intestinal barrier function. However, the precise mechanism remains to be unclear.Adult C57BL/6J mice were randomly divided into three groups: Sham, DSS and DSS + 6-formylindo ...
DOI:
10.1016/j.bbrc.2019.04.136

6. Biochemical and histological evidence of thyroid gland dysfunction in estradiol valerate model of the polycystic ovary in Wistar rats

Author:
Areej A. Alzahrani; Ahlam A. Alahmadi; Soad S. Ali; Bassam A. Alahmadi; Rana A. Arab; Lobna F. Wahman; Nagla A. El-Shitany
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 194-199
ISSN:
0006-291X
Subject:
animal ovaries; apoptosis; blood serum; caspase-3; estradiol; follicle-stimulating hormone; granules; heterochromatin; histology; humans; laboratory animals; luteinizing hormone; males; microscopy; models; proliferating cell nuclear antigen; rats; resorption; thyroid gland; thyroid hormones; thyrotropin
Abstract:
... Thyroid defects and polycystic ovary (PSO) disease are prevalent endocrine problems among humans. While various studies investigated the ovarian function and histological alterations during estradiol valerate model of PCO, yet, there were no available studies examining thyroid gland function and histology. Therefore, the present study aimed to investigate linkage between estradiol valerate-induced ...
DOI:
10.1016/j.bbrc.2019.04.126

7. Buforin-1 blocks neuronal SNARE-mediated membrane fusion by inhibiting SNARE complex assembly

Author:
Jung Gi Lee; Young-Joon Ko; Ji-Hye Choi; Min Jeong Jo; Youngsoo Jun; Jae Il Kim
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 105-111
ISSN:
0006-291X
Subject:
Bufo; SNARE proteins; antimicrobial peptides; botulinum toxin; exocytosis; membrane fusion; nervous system diseases; neurons; neurotransmitters; plasma membrane; synaptic vesicles; toads
Abstract:
... Assembly of neuronal SNARE protein complexes is essential for fusion of synaptic vesicles with the presynaptic plasma membrane, which releases neurotransmitters into the synaptic cleft and mediates neurotransmission. However, despite the potential of pharmacological regulation of this process for the treatment of various neurological disorders, only a few reagents, including botulinum neurotoxins, ...
DOI:
10.1016/j.bbrc.2019.04.124

8. Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II

Author:
Yosuke Osaki; Koji Matsuhisa; Wang Che; Masayuki Kaneko; Rie Asada; Takao Masaki; Kazunori Imaizumi; Atsushi Saito
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 217-223
ISSN:
0006-291X
Subject:
Dependoparvovirus; antibodies; behavior disorders; blood-brain barrier; calnexin; central nervous system; cognition; dermatan sulfate; endoplasmic reticulum; enzyme activity; enzyme replacement therapy; enzymes; genes; heparan sulfate; intravenous injection; lysosomes; mucopolysaccharidosis; mutants; mutation; transferrin receptors
Abstract:
... Mucopolysaccharidosis type II (MPS II) is one of the most common mucopolysaccharidoses, which is caused by mutation of the gene encoding iduronate 2-sulfatase (IDS). The loss of function of IDS leads to the accumulation of heparan sulfate and dermatan sulfate of glycosaminoglycans throughout the body, resulting in skeletal deformities, mental retardation, rigid joints, and thick skin. Recently, en ...
DOI:
10.1016/j.bbrc.2019.04.115

9. Cell-seeded porous silk fibroin scaffolds promotes axonal regeneration and myelination in spinal cord injury rats

Author:
Kemin You; Hongze Chang; Feng Zhang; Yixin Shen; Yan Zhang; Feng Cai; Liang Liu; Xiaodong Liu
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 273-279
ISSN:
0006-291X
Subject:
animal injuries; animal models; axons; fibroins; flow cytometry; mesenchymal stromal cells; myelin basic protein; myelin sheath; myelination; nerve regeneration; nerve tissue; rats; spinal cord
Abstract:
... Accumulating evidence indicates that a suitable scaffold designed for the spinal cord injury (SCI) was needed to enhance the survival of transplanted Bone mesenchymal stem cells (BMSCs) and to promote nerve regeneration. The current study was aimed to evaluate the effect of the porous silk fibroin scaffold (PSFSs) seeded with BMSCS on nerve regeneration, myelination and functional recovery after S ...
DOI:
10.1016/j.bbrc.2019.04.137

10. DjERas plays an important role in planarian regeneration and homeostasis

Author:
Qi Guo; Jiajia Ni; Fangfang Zhang; Yanan Guo; Yizhe Zhang; Huimin Fang; Qingnan Tian; Shoutao Zhang
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 205-209
ISSN:
0006-291X
Subject:
Dugesia; RNA interference; cell differentiation; cell proliferation; genes; genetic markers; homeostasis; progeny; signal transduction; stem cells
Abstract:
... The mechanisms of cell turnover including cell proliferation and cell differentiation were complex. Planarians possess amazing regeneration ability and undergo cell turnover throughout life. We identified a homologous gene of ERas by RNAi in Dugesia japonica. Knocking-down DjERas resulted in regeneration and homeostasis defects. Furthermore, we found that the expression of neoblasts and late proge ...
DOI:
10.1016/j.bbrc.2019.04.118

11. Downregulated circular RNA hsa_circ_0067301 regulates epithelial-mesenchymal transition in endometriosis via the miR-141/Notch signaling pathway

Author:
Mengmeng Zhang; Sixue Wang; Lu Tang; Xi Wang; Tingting Zhang; Xiaomeng Xia; Xiaoling Fang
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 71-77
ISSN:
0006-291X
Subject:
cadherins; circular RNA; endometrium; female genital diseases; gene expression regulation; microRNA; neoplasms; pathogenesis; protein synthesis; signal transduction; vimentin
Abstract:
... Endometriosis is a common gynecologic disorder with enigmatic etiopathogenesis and is characterized by tumor-like biological behaviors. Epithelial-mesenchymal transition (EMT) has been recognized as a core mechanism of endometriosis. Recently, circular RNAs (circRNAs) have attracted considerable attention because they play an important role in the progression of cancer. However, little is known ab ...
DOI:
10.1016/j.bbrc.2019.04.109

12. Exosomal miR-301 derived from mesenchymal stem cells protects myocardial infarction by inhibiting myocardial autophagy

Author:
Yong Li; Rong Yang; Bingyan Guo; Hongbo Zhang; Hui Zhang; Suyun Liu; Yongjun Li
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 323-328
ISSN:
0006-291X
Subject:
Western blotting; autophagy; cardiac output; echocardiography; exosomes; flow cytometry; mesenchymal stromal cells; messenger RNA; models; myocardial infarction; protective effect; proteins; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; staining
Abstract:
... To investigate the protective effects of miR-301 in exosomes secreted by bone mesenchymal stem cells (BMSCs) on rats' myocardial infarction (MI).After isolation and culture, BMSCs were identified using flow cytometry. Then exosomes were then isolated. Rats MI models were established and they were divided into 4 groups: Sham group, Model group (injected with PBS), BMSC-Exos group (injected with exo ...
DOI:
10.1016/j.bbrc.2019.04.138

13. Extracellular vesicles derived from the mid-to-late stage of osteoblast differentiation markedly enhance osteogenesis in vitro and in vivo

Author:
Yan Wei; Cuizhu Tang; Jinglun Zhang; Zhihao Li; Xiaoxin Zhang; Richard J. Miron; Yufeng Zhang
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 252-258
ISSN:
0006-291X
Subject:
bone formation; bones; cartilage; lymph; mesenchymal stromal cells; mice; mineralization; osteoblasts; osteoporosis; ovariectomy; tissue engineering
Abstract:
... Extracellular vesicles (EVs) play an important role in biological functions and may feature innate therapeutic potential for diseases. In the present study, EVs released by osteoblasts at different stages of the mineralization process were investigated for their potential ability to promote bone formation. Results showed that the characteristics of EVs of mineralizing osteoblasts changed with regu ...
DOI:
10.1016/j.bbrc.2019.04.029

14. FOXA1+ regulatory T cells: A novel T cell subset that suppresses antitumor immunity in lung cancer

Author:
Jinyan Liang; Chen Tian; Yulan Zeng; Qifan Yang; Yangyang Liu; Yuting Liu; Jingjing Wu; Yue Hu; Feifei Gu; Kai Zhang; Yan Wang; Yong Zhang; Li Liu
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 308-315
ISSN:
0006-291X
Subject:
T-lymphocytes; animal models; autoimmune diseases; blood sampling; disease control; immunity; in vitro studies; interferon-gamma; interleukin-2; liver; lung neoplasms; lungs; metastasis; patients; prognosis; tissues
Abstract:
... Regulatory T cells (Tregs) are important in the tumor microenvironment. Many subpopulations of Tregs have participated in suppressing antitumor immunity. Recently, FOXA1+ Tregs were reported as a novel subset of Tregs that control autoimmune diseases. However, their clinical value in lung cancer is unknown.We included 92 subjects in this study. Peripheral blood samples were collected from 15 lung ...
DOI:
10.1016/j.bbrc.2019.04.152

15. Fetal bovine serum enlarges the size of human pancreatic cancer spheres accompanied by an increase in the expression of cancer stem cell markers

Author:
Norihiko Sasaki; Masashi Toyoda; Fumio Hasegawa; Masakazu Fujiwara; Fujiya Gomi; Toshiyuki Ishiwata
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 112-117
ISSN:
0006-291X
Subject:
adenocarcinoma; carcinogenesis; cell lines; electron microscopy; epidermal growth factor; fetal bovine serum; fibroblast growth factor 2; genetic markers; histology; humans; metastasis; mortality; neoplasm cells; pancreatic neoplasms; stem cells; therapeutics
Abstract:
... Pancreatic ductal adenocarcinoma (PDAC) is a major histological type of pancreatic cancer and remains one of the most lethal cancers with a high mortality rate owing to its aggressive growth, high metastatic rate, and recurrence. Recent studies on cancer stem cells (CSCs) have suggested that the aggressive growth, high metastatic rate, and recurrence might be caused by the ability of CSCs to self- ...
DOI:
10.1016/j.bbrc.2019.04.117

16. Graphene oxide-assisted non-immobilized SELEX of chiral drug ephedrine aptamers and the analytical binding mechanism

Author:
Ligang Xing; Yuhui Zhang; Jidong Yang
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 134-139
ISSN:
0006-291X
Subject:
Gibbs free energy; binding capacity; colorimetry; dissociation; ephedrine; graphene; graphene oxide; high-throughput nucleotide sequencing; models; oligonucleotides; screening; single-stranded DNA; systematic evolution of ligands by exponential enrichment; titration
Abstract:
... Here, we describe a study of screen characterization of aptamers targeting the chiral drug ephedrine using the non-immobilized graphene oxide (GO) SELEX. The improved method of long and short chains was here used to prepare the ssDNA library. The Resonance Rayleigh Scattering (RRS) method was first used to monitor the screening process. Through high-throughput sequencing, the genetic sequence data ...
DOI:
10.1016/j.bbrc.2019.04.067

17. Hhip inhibits proliferation and promotes differentiation of adipocytes through suppressing hedgehog signaling pathway

Author:
Haiyan Wei; Jingjing Li; Shengjie Shi; Lutong Zhang; Aoqi Xiang; Xin'e Shi; Gongshe Yang; Guiyan Chu
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 148-156
ISSN:
0006-291X
Subject:
adipocytes; adipogenesis; adipose tissue; bacteriophages; body fat; cell cycle; cell proliferation; gene expression regulation; genes; lipid metabolism; lipids; obesity; obesity-related diseases; peroxisome proliferator-activated receptor gamma; signal transduction; swine
Abstract:
... Adipogenesis, which directly control body fat mass, plays a crucial role in lipid metabolism and obesity-related diseases. Hedgehog interacting protein (Hhip) belongs to Hedgehog (Hh) signaling pathway. The Hh signaling pathway was already linked with adipogenesis in previous reports, however, the physiological functions of Hhip on lipid deposition are still poorly understood. In this study, the l ...
DOI:
10.1016/j.bbrc.2019.04.047

18. Identification of the O-GalNAcylation site(s) on FOXA1 catalyzed by ppGalNAc-T2 enzyme in vitro

Author:
Siqi Zhang; Lijuan Bai; Qiushi Chen; Yan Ren; Keren Zhang; Qiong Wu; Huang Huang; Wenli Li; Yan Zhang; Jianing Zhang; Yubo Liu
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 157-165
ISSN:
0006-291X
Subject:
breast neoplasms; catalytic activity; chromatin; electrospray ionization mass spectrometry; gene expression; glycosylation; neoplasm progression; peptides; tandem mass spectrometry; transcription (genetics); transcription factors
Abstract:
... FOXA1 functions as a pioneer factor of transcriptional regulation that binds to specific sites in the chromatin and recruits other transcription factors, promoting the initiation of gene transcription and mediating the regulation of downstream target gene expression. FOXA1 was reported to facilitate or reprogram ERα binding, thus playing a key function in breast cancer progression. Our previous re ...
DOI:
10.1016/j.bbrc.2019.04.146

19. Insufficient PINX1 expression stimulates telomerase activation by direct inhibition of EBV LMP1-NF-κB axis during nasopharyngeal carcinoma development

Author:
Yunyi Liu; Pinggui Gong; Ni Zhou; Junjun Zhang; Cui He; Shuilian Wang; Hong Peng
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 127-133
ISSN:
0006-291X
Subject:
Human gammaherpesvirus 4; Southern blotting; Western blotting; bioluminescence assay; carcinoma; carrier state; cell growth; chromatin; early diagnosis; enzyme activity; enzyme inhibition; gene expression regulation; gene overexpression; membrane proteins; neoplasm cells; precipitin tests; quantitative polymerase chain reaction; signal transduction; telomerase; telomeres; transcription (genetics); transcription factor NF-kappa B; tumor suppressor genes
Abstract:
... Early malignant transformation of nasopharyngeal carcinoma(NPC) is associated with Epstein-Barr virus(EBV) infection and telomerase activation. The EBV latent membrane protein 1(LMP1) regulates expression of various genes by triggering NF-κB signaling pathway. PINX1 is a well-identified tumor suppressor gene by inhibiting telomerase activity and cancer cell growth. However, whether and how EBV inh ...
DOI:
10.1016/j.bbrc.2019.04.104

20. KLF7 promotes polyamine biosynthesis and glioma development through transcriptionally activating ASL

Author:
Feng Guan; Zhuang Kang; Jun-Ting Zhang; Ni-Na Xue; Hui Yin; Liang Wang; Bei-Bei Mao; Wei-Cheng Peng; Bo-Lun Zhang; Xin Liang; Zhi-Qiang Hu
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 51-57
ISSN:
0006-291X
Subject:
argininosuccinate lyase; biosynthesis; carcinogenesis; gene expression; glioma; metabolites; oncogenes; patients; polyamines; tissues; transcription (genetics); transcription factors; urea cycle; zinc finger motif
Abstract:
... Krüppel-like factors (KLFs) are zinc-finger transcriptional factors that regulate target gene expression. Recent studies have shown that KLFs play essential roles in cancer development, whereas the function of KLF7 in glioma remains unclear. In this study, we showed that KLF7 was up-regulated in glioma tissues and its expression was inversely correlated with the patients’ survival. Functional expe ...
DOI:
10.1016/j.bbrc.2019.04.120