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- Author:
- Kitazume-Taneike, Rika; Taneike, Manabu; Omiya, Shigemiki; Misaka, Tomofumi; Nishida, Kazuhiko; Yamaguchi, Osamu; Akira, Shizuo; Shattock, Michael J.; Sakata, Yasushi; Otsu, Kinya
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 442-447
- ISSN:
- 0006-291X
- Subject:
- Toll-like receptor 9; deoxyribonuclease I; heart; infarction; inflammation; mice; mitochondria; mitochondrial DNA; myocardial ischemia; reperfusion injury; signal transduction; therapeutics
- Abstract:
- ... In myocardial ischemia/reperfusion injury, the innate immune and subsequent inflammatory responses play a crucial role in the extension of myocardial damage. Toll-like receptor 9 (TLR9) is a critical receptor for recognizing unmethylated CpG motifs that mitochondria contain in their DNA, and induces inflammatory responses. The aim of this study was to elucidate the role of TLR9 in myocardial ische ...
- DOI:
- 10.1016/j.bbrc.2019.05.150
- PubMed:
- 31160091
- PubMed Central:
- PMC6590932
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.150
- Author:
- Izuo, Naotaka; Murakami, Kazuma; Fujihara, Yoshitaka; Maeda, Masahiro; Saito, Takashi; Saido, Takaomi C.; Irie, Kazuhiro; Shimizu, Takahiko
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 462-467
- ISSN:
- 0006-291X
- Subject:
- Alzheimer disease; animal models; brain; cognition; cognitive disorders; enzyme-linked immunosorbent assay; immunization; immunohistochemistry; mice; molecular weight; mutation; neurotoxicity; patients; phenotype
- Abstract:
- ... Irie and colleagues identified a “toxic conformer”, which possesses a turn structure at positions 22-23, among various conformations of Aβ and have been reporting its potent oligomeric capacity and neurotoxicity. This toxic conformer was detected in the brains of AD patients and AD model mice (Tg2576 line), and passive immunization targeting this conformer ameliorated the cognitive dysfunction in ...
- DOI:
- 10.1016/j.bbrc.2019.05.131
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.131
- Author:
- Xue, Hanbing; Sun, Lin; Fujimoto, Hirofumi; Suzuki, Tadaki; Takahashi, Yoshimasa; Ohnishi, Kazuo
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 481-486
- ISSN:
- 0006-291X
- Subject:
- antibodies; antigens; genes; genetic engineering; high-throughput nucleotide sequencing; immune response; immunoglobulin heavy chains; immunoglobulin light chains; protein synthesis; prototypes
- Abstract:
- ... Immunoglobulins play important roles in antigen recognition during the immune response, and the complementarity-determining region (CDR) 3 of the heavy chain is considered as the critical antigen-binding site. We previously developed a statistical protocol for the extensive analysis of heavy chain variable region repertoires and the dynamics of their immune response using next-generation sequencin ...
- DOI:
- 10.1016/j.bbrc.2019.05.149
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.149
- Author:
- Lee, Soonje; Lee, Changwoo; Woo, Changsu; Kang, Shin Jung; Shin, Ki Soon
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 468-473
- ISSN:
- 0006-291X
- Subject:
- hippocampus; mice; neurons; stress response
- Abstract:
- ... The ventral subiculum (vSub) is the major output structure of the hippocampus and serves as a main limbic region in mediating the brain's response to stress. Previously, we reported that there are three subtypes of vSub neurons based on their firing patterns: regular-spiking (RS), weak-bursting (WB) and strong-bursting (SB) neurons and chronic social defeat stress (CSDS) increased SB neurons espec ...
- DOI:
- 10.1016/j.bbrc.2019.05.180
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.180
- Author:
- Liu, Jianan; Yang, Li; Liu, Feifei; Li, Heng; Tang, Wei; Tong, Xiankun; Zuo, Jianping
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 403-409
- ISSN:
- 0006-291X
- Subject:
- Dengue virus; RNA interference; RNA replication; dengue; enzymes; genes; innate immunity; messenger RNA; protein synthesis; public health
- Abstract:
- ... Dengue virus (DENV) infection is a public health problem worldwide. To establish infection in host cells, DENV require host cellular mechanism to suppress and evade innate immunity for their replication. In this study, Ccr4-Not complex genes were screened by using RNAi approach in DENV-infected A549 and Huh7 cells. We found that CNOT2 plays a proviral role in DENV infection. The expression level o ...
- DOI:
- 10.1016/j.bbrc.2019.05.083
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.083
- Author:
- Zhao, Yan-Yan; Jiang, Yong-Liang; Chen, Yuxing; Zhou, Cong-Zhao; Li, Qiong
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 510-515
- ISSN:
- 0006-291X
- Subject:
- Halothiobacillus; carbon dioxide; carbon dioxide fixation; crystal structure; encapsulation; proteins
- Abstract:
- ... Carboxysome, encapsulating an enzymatic core within an icosahedral-shaped semipermeable protein shell, could enhance CO2 fixation under low CO2 conditions in the environment. The shell of Halothiobacillus neapolitanus α-carboxysome possesses two 38% sequence-identical pentameric proteins, namely CsoS4A and CsoS4B. However, the functions of two paralogous pentameric proteins in α-carboxysome assemb ...
- DOI:
- 10.1016/j.bbrc.2019.05.047
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.047
- Author:
- EL-Sayed, R.; Waraky, A.; Ezzat, K.; Albabtain, R.; ElGammal, K.; Shityakov, S.; Muhammed, M.; Hassan, M.
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 487-492
- ISSN:
- 0006-291X
- Subject:
- DNA damage; Raman spectroscopy; biodegradation; carbon; carbon nanotubes; cell lines; cytochrome P-450; electron microscopy; enzymes; granuloma; inflammation; isozymes; liver; lungs; models; optical properties; oxidation; oxidative stress; toxicity; viability; xenobiotics
- Abstract:
- ... Carbon nanotubes (CNTs) are a class of carbon based nanomaterials which have attracted substantial attention in recent years as they exhibit outstanding physical, mechanical and optical properties. In the last decade many studies have emerged of the underlying mechanisms behind CNT toxicity including malignant transformation, the formation of granulomas, inflammatory responses, oxidative stress, D ...
- DOI:
- 10.1016/j.bbrc.2019.05.097
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.097
- Author:
- Huang, Feng; Sheng, Xu-Xiang; Zhang, Hong-Juan
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 410-416
- ISSN:
- 0006-291X
- Subject:
- animal models; apoptosis; basement membrane; cell growth; cortex; diabetic nephropathy; fibrosis; gene targeting; glucose; hydrogen peroxide; inflammation; kidneys; mice; mitogen-activated protein kinase; oxidative stress; patients; renal failure; streptozotocin; superoxide dismutase; therapeutics; transforming growth factor beta 1
- Abstract:
- ... Diabetic nephropathy (DN) is a leading cause of renal failure worldwide. Unfortunately, the pathogenetic mechanism of DN is far from to be understood. Dual-specificity phosphatase 26 (DUSP26) is a member of the Dusp protein family, and is suggested to be involved in divers biological and pathological processes, such as cell growth, differentiation, inflammation and apoptosis. However, its role in ...
- DOI:
- 10.1016/j.bbrc.2019.05.032
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.032
- Author:
- Junliang, Lu; Lili, Wang; Xiaolong, Liang; Xuguang, Liu; Huanwen, Wu; Zhiyong, Liang
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 493-498
- ISSN:
- 0006-291X
- Subject:
- cell movement; hyaluronan synthase; hyaluronic acid; hyaluronoglucosaminidase; molecular weight; neoplasm cells; pancreatic neoplasms; paracrine signaling; quantitative polymerase chain reaction; tissues
- Abstract:
- ... The polysaccharide hyaluronan (HA) is abundant in pancreatic cancer (PC) tissue and promotes pancreatic cancer cell (PCC) motility in vitro. However, it is controversial as to whether high-molecular-weight HA (HMW-HA) or low-molecular weight HA(LMW-HA) is present in the pancreatic cancer stroma and whether PCC or pancreatic stellate cell (PSC) in PC tissue produces HA. We thereby aim to characteri ...
- DOI:
- 10.1016/j.bbrc.2019.05.167
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.167
- Author:
- Li, Guangqi; Chen, Xiaojuan; Zhou, Xuan; Huang, Rong; Li, Lingbo; Miao, Youzhi; Liu, Dongyang; Zhang, Ruifu
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 417-422
- ISSN:
- 0006-291X
- Subject:
- Aspergillus fumigatus; active sites; carbohydrate binding; composting; fungi; industrial applications; models; molecular dynamics; thermal stability; xylanases
- Abstract:
- ... Xylanase is an important enzyme in industrial applications, which usually require the enzyme to maintain activity in high-temperature condition. In this study, a GH10 family xylanase XynAF0 from a thermophilic composting fungus, Aspergillus fumigatus Z5, was investigated to determine its thermostable mechanism. XynAF0 showed excellent thermostability, which could maintain 50% relative activity aft ...
- DOI:
- 10.1016/j.bbrc.2019.05.163
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.163
- Author:
- Yang, Yong; Dai, Zhiming; Dai, Xianhua
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 423-428
- ISSN:
- 0006-291X
- Subject:
- epigenetics; genes; histones; transcription (genetics)
- Abstract:
- ... Enhancers can regulate gene transcription from afar. Many enhancers are located in genes. Although the regulatory roles of several individual intragenic enhancers have been elaborated, a genome-wide insight into intragenic enhancers remains to be elucidated. We found that active intragenic enhancers have a preference for being located in expressed genes. Unlike intergenic enhancers, active intrage ...
- DOI:
- 10.1016/j.bbrc.2019.05.160
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.160
- Author:
- Mandal, Bitapi; Mondal, Hasanat Karim; Das, Saurabh
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 505-509
- ISSN:
- 0006-291X
- Subject:
- DNA; anthracyclines; antineoplastic activity; antineoplastic agents; calves; clinical trials; cytotoxicity; drug toxicity; electrochemistry; electron transfer; emodin; free radicals; glassy carbon electrode; mechanism of action; moieties; nucleobases; oxygen; superoxide anion; therapeutics; thymus gland
- Abstract:
- ... There is enough proof to believe that free-radical intermediates of anthracycline based anticancer agents are involved in different stages of drug action. Subtle therapeutic differences observed in the actions of different anthracyclines largely influence the mechanism of action of the drugs that distinguish one member from another. Redox properties control biological responses related either to t ...
- DOI:
- 10.1016/j.bbrc.2019.05.140
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.140
- Author:
- Yuan, Qi; Zhang, Zheng; Hu, Xiaoxuan; Liao, Jinmao; Kuang, Jia
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 499-504
- ISSN:
- 0006-291X
- Subject:
- collagen; free radicals; hepatocytes; interleukin-6; iron; iron overload; liver cirrhosis; oxidative stress; oxygen; transcription (genetics); transforming growth factor beta 1
- Abstract:
- ... The transformation of hepatic stellate cells (HSCs) to activated myofibroblasts plays a critical role in the progression of hepatic fibrosis, while iron-catalyzed production of free radical, including reaction and active oxygen (ROS), and activation and transformation of HSC into a myofibroblasts has been regarded as a major mechanism. In the present study, we attempted to investigate the mechanis ...
- DOI:
- 10.1016/j.bbrc.2019.05.152
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.152
- Author:
- Xiao, Feng-Jun; Zhang, Dan; Wu, Ye; Jia, Qing-Hua; Zhang, Lin; Li, Yu-Xiang; Yang, Yue-Feng; Wang, Hua; Wu, Chu-Tse; Wang, Li-Sheng
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 448-454
- ISSN:
- 0006-291X
- Subject:
- Lentivirus; angiogenesis; atherosclerosis; cell death; growth retardation; human umbilical vein endothelial cells; ischemia; lipoproteins; microRNA; neoplasms; precipitin tests; zinc
- Abstract:
- ... Endothelial cell death is linked to vascular diseases such as atherosclerosis and tissue ischemia. miRNA-17-92 (miR-17–92) is a multiple functional oncogenic miRNA cluster which plays vital roles in tumor angiogenesis and tissue development. However, its role in regulation of endothelial cell ferroptosis remains unclear. In this study, we revealed that miR-17–92 protects endothelial HUVEC cells fr ...
- DOI:
- 10.1016/j.bbrc.2019.05.147
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.147
- Author:
- Zhao, Yan; Nie, Ming; Xu, Peng; Li, Hua; Xu, Lei; Cheng, Xue-Qi; Lei, Yan-Qing
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 474-480
- ISSN:
- 0006-291X
- Subject:
- acute kidney injury; kidneys; mice; oxidative stress; protective effect; reactive oxygen species
- Abstract:
- ... Nitrosporeusine A (NA) has been recently reported to exert anti-inflammatory and renal protective effects, but whether NA can attenuate sepsis-associated acute kidney injury (AKI) has not yet been reported. In this study, our results found that cecal ligation and puncture (CLP) reduced renal PGC-1α expression and induced oxidative stress in C57BL/6 mice. PGC-1α overexpression attenuated CLP-induce ...
- DOI:
- 10.1016/j.bbrc.2019.05.151
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.151
- Author:
- Zhang, Yixuan; Sun, Linlin; Liu, E; Wang, Aibo; Yan, Junhao
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 429-435
- ISSN:
- 0006-291X
- Subject:
- aquaporins; astrocytes; breathing; central nervous system diseases; drainage; eugenol; extracellular space; gene silencing; genes; hippocampus; neurons; olfactory perception; rats; sensory system; smell
- Abstract:
- ... Accelerating the clearance of toxin in the brain extracellular space (ECS) has grown a promising strategy for treating some central nervous system diseases. As oldest sensory system, we know little about the influence of olfaction on the brain, but preclinical studies such as treatment of neurological diseases through it are in the ascendant. This makes it important to clarify the effects of olfac ...
- DOI:
- 10.1016/j.bbrc.2019.05.159
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.159
- Author:
- Chen, Chunyou; Mei, Qin; Wang, Linlin; Feng, Xuewen; Tao, Xiaoxiao; Qiu, Chenfeng; Zhu, Jingang
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 436-441
- ISSN:
- 0006-291X
- Subject:
- NADP (coenzyme); Western blotting; analytical kits; antioxidants; apoptosis; astrocytes; epilepsy; fluorescent antibody technique; glutathione; glycolysis; neurons; oxidative stress; pentose phosphate cycle; proteins; rats; seizures; staining
- Abstract:
- ... TP53-induced glycolysis and apoptosis regulator (TIGAR) activates the pentose phosphate pathway (PPP), which feeds reduced nicotinamide adenine dinucleotide phosphate (NADPH) to the antioxidant glutathione pathway. Oxidative stress-induced neuronal apoptosis is the pathological basis of several neurological disorders, including epilepsy. To determine the potential anti-epileptic action TIGAR in a ...
- DOI:
- 10.1016/j.bbrc.2019.05.156
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.156
- Author:
- Han, Ming; Lu, Hongping; Han, Kai; Yuan, Xiaoxue; Liu, Shunai; Wang, Yun; Zhao, Jing; Liang, Pu; Cheng, Jun
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.3 pp. 455-461
- ISSN:
- 0006-291X
- Subject:
- Hepatitis B virus; apoptosis; cell proliferation; chronic hepatitis B; databases; death; hepatoma; human cell lines; immunohistochemistry; mice; oncogenes; patients; protein synthesis; thiostrepton; tissues; transactivators
- Abstract:
- ... Hepatocellular carcinoma (HCC) is one of the most common cancer in the world and the main cause of cancer death. Chronic hepatitis B virus (HBV) infection is the major cause of HCC. HBx, as a transactivator, plays an important role in the occurrence and development process of HCC leading by HBV infection. XTP8, related to HBx, however, there are no studies on the function of XTP8 in HCC. In our re ...
- DOI:
- 10.1016/j.bbrc.2019.05.164
-
https://dx.doi.org/10.1016/j.bbrc.2019.05.164