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You searched for: Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Publication Year 2019 Remove constraint Publication Year: 2019 Source 2019 v.515 no.3 Remove constraint Source: 2019 v.515 no.3
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1. Ablation of Toll-like receptor 9 attenuates myocardial ischemia/reperfusion injury in mice

Author:
Kitazume-Taneike, Rika; Taneike, Manabu; Omiya, Shigemiki; Misaka, Tomofumi; Nishida, Kazuhiko; Yamaguchi, Osamu; Akira, Shizuo; Shattock, Michael J.; Sakata, Yasushi; Otsu, Kinya
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 442-447
ISSN:
0006-291X
Subject:
Toll-like receptor 9; deoxyribonuclease I; heart; infarction; inflammation; mice; mitochondria; mitochondrial DNA; myocardial ischemia; reperfusion injury; signal transduction; therapeutics
Abstract:
... In myocardial ischemia/reperfusion injury, the innate immune and subsequent inflammatory responses play a crucial role in the extension of myocardial damage. Toll-like receptor 9 (TLR9) is a critical receptor for recognizing unmethylated CpG motifs that mitochondria contain in their DNA, and induces inflammatory responses. The aim of this study was to elucidate the role of TLR9 in myocardial ische ...
DOI:
10.1016/j.bbrc.2019.05.150
PubMed:
31160091
PubMed Central:
PMC6590932

2. An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease

Author:
Izuo, Naotaka; Murakami, Kazuma; Fujihara, Yoshitaka; Maeda, Masahiro; Saito, Takashi; Saido, Takaomi C.; Irie, Kazuhiro; Shimizu, Takahiko
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 462-467
ISSN:
0006-291X
Subject:
Alzheimer disease; animal models; brain; cognition; cognitive disorders; enzyme-linked immunosorbent assay; immunization; immunohistochemistry; mice; molecular weight; mutation; neurotoxicity; patients; phenotype
Abstract:
... Irie and colleagues identified a “toxic conformer”, which possesses a turn structure at positions 22-23, among various conformations of Aβ and have been reporting its potent oligomeric capacity and neurotoxicity. This toxic conformer was detected in the brains of AD patients and AD model mice (Tg2576 line), and passive immunization targeting this conformer ameliorated the cognitive dysfunction in ...
DOI:
10.1016/j.bbrc.2019.05.131

3. Artificial immunoglobulin light chain with potential to associate with a wide variety of immunoglobulin heavy chains

Author:
Xue, Hanbing; Sun, Lin; Fujimoto, Hirofumi; Suzuki, Tadaki; Takahashi, Yoshimasa; Ohnishi, Kazuo
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 481-486
ISSN:
0006-291X
Subject:
antibodies; antigens; genes; genetic engineering; high-throughput nucleotide sequencing; immune response; immunoglobulin heavy chains; immunoglobulin light chains; protein synthesis; prototypes
Abstract:
... Immunoglobulins play important roles in antigen recognition during the immune response, and the complementarity-determining region (CDR) 3 of the heavy chain is considered as the critical antigen-binding site. We previously developed a statistical protocol for the extensive analysis of heavy chain variable region repertoires and the dynamics of their immune response using next-generation sequencin ...
DOI:
10.1016/j.bbrc.2019.05.149

4. Chronic social defeat stress increases burst firing of nucleus accumbens-projecting ventral subicular neurons in stress-susceptible mice

Author:
Lee, Soonje; Lee, Changwoo; Woo, Changsu; Kang, Shin Jung; Shin, Ki Soon
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 468-473
ISSN:
0006-291X
Subject:
hippocampus; mice; neurons; stress response
Abstract:
... The ventral subiculum (vSub) is the major output structure of the hippocampus and serves as a main limbic region in mediating the brain's response to stress. Previously, we reported that there are three subtypes of vSub neurons based on their firing patterns: regular-spiking (RS), weak-bursting (WB) and strong-bursting (SB) neurons and chronic social defeat stress (CSDS) increased SB neurons espec ...
DOI:
10.1016/j.bbrc.2019.05.180

5. CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway

Author:
Liu, Jianan; Yang, Li; Liu, Feifei; Li, Heng; Tang, Wei; Tong, Xiankun; Zuo, Jianping
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 403-409
ISSN:
0006-291X
Subject:
Dengue virus; RNA interference; RNA replication; dengue; enzymes; genes; innate immunity; messenger RNA; protein synthesis; public health
Abstract:
... Dengue virus (DENV) infection is a public health problem worldwide. To establish infection in host cells, DENV require host cellular mechanism to suppress and evade innate immunity for their replication. In this study, Ccr4-Not complex genes were screened by using RNAi approach in DENV-infected A549 and Huh7 cells. We found that CNOT2 plays a proviral role in DENV infection. The expression level o ...
DOI:
10.1016/j.bbrc.2019.05.083

6. Crystal structure of pentameric shell protein CsoS4B of Halothiobacillus neapolitanus α-carboxysome

Author:
Zhao, Yan-Yan; Jiang, Yong-Liang; Chen, Yuxing; Zhou, Cong-Zhao; Li, Qiong
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 510-515
ISSN:
0006-291X
Subject:
Halothiobacillus; carbon dioxide; carbon dioxide fixation; crystal structure; encapsulation; proteins
Abstract:
... Carboxysome, encapsulating an enzymatic core within an icosahedral-shaped semipermeable protein shell, could enhance CO2 fixation under low CO2 conditions in the environment. The shell of Halothiobacillus neapolitanus α-carboxysome possesses two 38% sequence-identical pentameric proteins, namely CsoS4A and CsoS4B. However, the functions of two paralogous pentameric proteins in α-carboxysome assemb ...
DOI:
10.1016/j.bbrc.2019.05.047

7. Degradation of pristine and oxidized single wall carbon nanotubes by CYP3A4

Author:
EL-Sayed, R.; Waraky, A.; Ezzat, K.; Albabtain, R.; ElGammal, K.; Shityakov, S.; Muhammed, M.; Hassan, M.
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 487-492
ISSN:
0006-291X
Subject:
DNA damage; Raman spectroscopy; biodegradation; carbon; carbon nanotubes; cell lines; cytochrome P-450; electron microscopy; enzymes; granuloma; inflammation; isozymes; liver; lungs; models; optical properties; oxidation; oxidative stress; toxicity; viability; xenobiotics
Abstract:
... Carbon nanotubes (CNTs) are a class of carbon based nanomaterials which have attracted substantial attention in recent years as they exhibit outstanding physical, mechanical and optical properties. In the last decade many studies have emerged of the underlying mechanisms behind CNT toxicity including malignant transformation, the formation of granulomas, inflammatory responses, oxidative stress, D ...
DOI:
10.1016/j.bbrc.2019.05.097

8. DUSP26 regulates podocyte oxidative stress and fibrosis in a mouse model with diabetic nephropathy through the mediation of ROS

Author:
Huang, Feng; Sheng, Xu-Xiang; Zhang, Hong-Juan
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 410-416
ISSN:
0006-291X
Subject:
animal models; apoptosis; basement membrane; cell growth; cortex; diabetic nephropathy; fibrosis; gene targeting; glucose; hydrogen peroxide; inflammation; kidneys; mice; mitogen-activated protein kinase; oxidative stress; patients; renal failure; streptozotocin; superoxide dismutase; therapeutics; transforming growth factor beta 1
Abstract:
... Diabetic nephropathy (DN) is a leading cause of renal failure worldwide. Unfortunately, the pathogenetic mechanism of DN is far from to be understood. Dual-specificity phosphatase 26 (DUSP26) is a member of the Dusp protein family, and is suggested to be involved in divers biological and pathological processes, such as cell growth, differentiation, inflammation and apoptosis. However, its role in ...
DOI:
10.1016/j.bbrc.2019.05.032

9. High-molecular-weight hyaluronan produced by activated pancreatic stellate cells promotes pancreatic cancer cell migration via paracrine signaling

Author:
Junliang, Lu; Lili, Wang; Xiaolong, Liang; Xuguang, Liu; Huanwen, Wu; Zhiyong, Liang
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 493-498
ISSN:
0006-291X
Subject:
cell movement; hyaluronan synthase; hyaluronic acid; hyaluronoglucosaminidase; molecular weight; neoplasm cells; pancreatic neoplasms; paracrine signaling; quantitative polymerase chain reaction; tissues
Abstract:
... The polysaccharide hyaluronan (HA) is abundant in pancreatic cancer (PC) tissue and promotes pancreatic cancer cell (PCC) motility in vitro. However, it is controversial as to whether high-molecular-weight HA (HMW-HA) or low-molecular weight HA(LMW-HA) is present in the pancreatic cancer stroma and whether PCC or pancreatic stellate cell (PSC) in PC tissue produces HA. We thereby aim to characteri ...
DOI:
10.1016/j.bbrc.2019.05.167

10. Improvement of GH10 family xylanase thermostability by introducing of an extra α-helix at the C-terminal

Author:
Li, Guangqi; Chen, Xiaojuan; Zhou, Xuan; Huang, Rong; Li, Lingbo; Miao, Youzhi; Liu, Dongyang; Zhang, Ruifu
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 417-422
ISSN:
0006-291X
Subject:
Aspergillus fumigatus; active sites; carbohydrate binding; composting; fungi; industrial applications; models; molecular dynamics; thermal stability; xylanases
Abstract:
... Xylanase is an important enzyme in industrial applications, which usually require the enzyme to maintain activity in high-temperature condition. In this study, a GH10 family xylanase XynAF0 from a thermophilic composting fungus, Aspergillus fumigatus Z5, was investigated to determine its thermostable mechanism. XynAF0 showed excellent thermostability, which could maintain 50% relative activity aft ...
DOI:
10.1016/j.bbrc.2019.05.163

11. Insights into active intragenic enhancers

Author:
Yang, Yong; Dai, Zhiming; Dai, Xianhua
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 423-428
ISSN:
0006-291X
Subject:
epigenetics; genes; histones; transcription (genetics)
Abstract:
... Enhancers can regulate gene transcription from afar. Many enhancers are located in genes. Although the regulatory roles of several individual intragenic enhancers have been elaborated, a genome-wide insight into intragenic enhancers remains to be elucidated. We found that active intragenic enhancers have a preference for being located in expressed genes. Unlike intergenic enhancers, active intrage ...
DOI:
10.1016/j.bbrc.2019.05.160

12. In situ reactivity of electrochemically generated semiquinone on Emodin and its CuII/MnII complexes with pyrimidine based nucleic acid bases and calf thymus DNA: Insight into free radical induced cytotoxicity of anthracyclines

Author:
Mandal, Bitapi; Mondal, Hasanat Karim; Das, Saurabh
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 505-509
ISSN:
0006-291X
Subject:
DNA; anthracyclines; antineoplastic activity; antineoplastic agents; calves; clinical trials; cytotoxicity; drug toxicity; electrochemistry; electron transfer; emodin; free radicals; glassy carbon electrode; mechanism of action; moieties; nucleobases; oxygen; superoxide anion; therapeutics; thymus gland
Abstract:
... There is enough proof to believe that free-radical intermediates of anthracycline based anticancer agents are involved in different stages of drug action. Subtle therapeutic differences observed in the actions of different anthracyclines largely influence the mechanism of action of the drugs that distinguish one member from another. Redox properties control biological responses related either to t ...
DOI:
10.1016/j.bbrc.2019.05.140

13. miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-β1 and IL-6

Author:
Yuan, Qi; Zhang, Zheng; Hu, Xiaoxuan; Liao, Jinmao; Kuang, Jia
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 499-504
ISSN:
0006-291X
Subject:
collagen; free radicals; hepatocytes; interleukin-6; iron; iron overload; liver cirrhosis; oxidative stress; oxygen; transcription (genetics); transforming growth factor beta 1
Abstract:
... The transformation of hepatic stellate cells (HSCs) to activated myofibroblasts plays a critical role in the progression of hepatic fibrosis, while iron-catalyzed production of free radical, including reaction and active oxygen (ROS), and activation and transformation of HSC into a myofibroblasts has been regarded as a major mechanism. In the present study, we attempted to investigate the mechanis ...
DOI:
10.1016/j.bbrc.2019.05.152

14. miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis

Author:
Xiao, Feng-Jun; Zhang, Dan; Wu, Ye; Jia, Qing-Hua; Zhang, Lin; Li, Yu-Xiang; Yang, Yue-Feng; Wang, Hua; Wu, Chu-Tse; Wang, Li-Sheng
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 448-454
ISSN:
0006-291X
Subject:
Lentivirus; angiogenesis; atherosclerosis; cell death; growth retardation; human umbilical vein endothelial cells; ischemia; lipoproteins; microRNA; neoplasms; precipitin tests; zinc
Abstract:
... Endothelial cell death is linked to vascular diseases such as atherosclerosis and tissue ischemia. miRNA-17-92 (miR-17–92) is a multiple functional oncogenic miRNA cluster which plays vital roles in tumor angiogenesis and tissue development. However, its role in regulation of endothelial cell ferroptosis remains unclear. In this study, we revealed that miR-17–92 protects endothelial HUVEC cells fr ...
DOI:
10.1016/j.bbrc.2019.05.147

15. Nitrosporeusine A attenuates sepsis-associated acute kidney injury through the downregulation of IL-6/sIL-6R axis activation-mediated PGC-1α suppression

Author:
Zhao, Yan; Nie, Ming; Xu, Peng; Li, Hua; Xu, Lei; Cheng, Xue-Qi; Lei, Yan-Qing
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 474-480
ISSN:
0006-291X
Subject:
acute kidney injury; kidneys; mice; oxidative stress; protective effect; reactive oxygen species
Abstract:
... Nitrosporeusine A (NA) has been recently reported to exert anti-inflammatory and renal protective effects, but whether NA can attenuate sepsis-associated acute kidney injury (AKI) has not yet been reported. In this study, our results found that cecal ligation and puncture (CLP) reduced renal PGC-1α expression and induced oxidative stress in C57BL/6 mice. PGC-1α overexpression attenuated CLP-induce ...
DOI:
10.1016/j.bbrc.2019.05.151

16. The olfactory stimulation slows down the substance clearance in the extracellular space of the hippocampus in rat brain

Author:
Zhang, Yixuan; Sun, Linlin; Liu, E; Wang, Aibo; Yan, Junhao
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 429-435
ISSN:
0006-291X
Subject:
aquaporins; astrocytes; breathing; central nervous system diseases; drainage; eugenol; extracellular space; gene silencing; genes; hippocampus; neurons; olfactory perception; rats; sensory system; smell
Abstract:
... Accelerating the clearance of toxin in the brain extracellular space (ECS) has grown a promising strategy for treating some central nervous system diseases. As oldest sensory system, we know little about the influence of olfaction on the brain, but preclinical studies such as treatment of neurological diseases through it are in the ascendant. This makes it important to clarify the effects of olfac ...
DOI:
10.1016/j.bbrc.2019.05.159

17. TIGAR suppresses seizures induced by kainic acid through inhibiting oxidative stress and neuronal apoptosis

Author:
Chen, Chunyou; Mei, Qin; Wang, Linlin; Feng, Xuewen; Tao, Xiaoxiao; Qiu, Chenfeng; Zhu, Jingang
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 436-441
ISSN:
0006-291X
Subject:
NADP (coenzyme); Western blotting; analytical kits; antioxidants; apoptosis; astrocytes; epilepsy; fluorescent antibody technique; glutathione; glycolysis; neurons; oxidative stress; pentose phosphate cycle; proteins; rats; seizures; staining
Abstract:
... TP53-induced glycolysis and apoptosis regulator (TIGAR) activates the pentose phosphate pathway (PPP), which feeds reduced nicotinamide adenine dinucleotide phosphate (NADPH) to the antioxidant glutathione pathway. Oxidative stress-induced neuronal apoptosis is the pathological basis of several neurological disorders, including epilepsy. To determine the potential anti-epileptic action TIGAR in a ...
DOI:
10.1016/j.bbrc.2019.05.156

18. XTP8 promotes hepatocellular carcinoma growth by forming a positive feedback loop with FOXM1 oncogene

Author:
Han, Ming; Lu, Hongping; Han, Kai; Yuan, Xiaoxue; Liu, Shunai; Wang, Yun; Zhao, Jing; Liang, Pu; Cheng, Jun
Source:
Biochemical and biophysical research communications 2019 v.515 no.3 pp. 455-461
ISSN:
0006-291X
Subject:
Hepatitis B virus; apoptosis; cell proliferation; chronic hepatitis B; databases; death; hepatoma; human cell lines; immunohistochemistry; mice; oncogenes; patients; protein synthesis; thiostrepton; tissues; transactivators
Abstract:
... Hepatocellular carcinoma (HCC) is one of the most common cancer in the world and the main cause of cancer death. Chronic hepatitis B virus (HBV) infection is the major cause of HCC. HBx, as a transactivator, plays an important role in the occurrence and development process of HCC leading by HBV infection. XTP8, related to HBx, however, there are no studies on the function of XTP8 in HCC. In our re ...
DOI:
10.1016/j.bbrc.2019.05.164