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- Avrova, Stanislava V.; Karpicheva, Olga E.; Simonyan, Armen O.; Sirenko, Vladimir V.; Redwood, Charles S.; Borovikov, Yurii S.
- Biochemical and biophysical research communications 2019 v.515 no.2 pp. 372-377
- myosin, etc ; actin; adenosinetriphosphatase; calcium; fluorescence microscopy; muscle fibers; muscles; mutants; mutation; patients; Show all 10 Subjects
- ... Substitution of Ala for Thr residue in 155th position in γ-tropomyosin (Tpm3.12) is associated with muscle weakness. To understand the mechanisms of this defect, we studied the Ca2+-sensitivity of thin filaments in solution and multistep changes in mobility and spatial arrangement of actin, Tpm, and myosin heads during the ATPase cycle in reconstituted muscle fibres, using the polarized fluorescen ...