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- Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
- Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
- CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
- ... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
- Yu Shang; Li Tian; Tianjiao Chen; Xiaoying Liu; Jilin Zhang; Dongxin Liu; Jiayi Wei; Wengang Fang; Yuhua Chen; Deshu Shang
- Biochemical and biophysical research communications 2019 v.515 no.1 pp. 201-206
- Alzheimer disease; astrocytes; cell proliferation; cerebrospinal fluid; chemokine CXCL1; macrophages; mice; neural stem cells; patients; reactive oxygen species
- ... Elevated levels of CXCL1 were observed in the cerebrospinal fluid of patients with early Alzheimer's disease, which may affect neural stem cells in the subventricular zone. We used APP/PS1 mice and neural stem cells to elucidate the role of CXCL1 in Alzheimer's disease.We detected CXCL1 in cerebrospinal fluid (CSF), activated macrophages, and microglia suggesting that macrophages may contribute to ...