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You searched for: Author "Xia, Hong" Remove constraint Author: "Xia, Hong" Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Publication Year 2019 Remove constraint Publication Year: 2019 Subject humans Remove constraint Subject: humans Subject cerebrospinal fluid Remove constraint Subject: cerebrospinal fluid Subject biotin Remove constraint Subject: biotin Subject CD8-positive T-lymphocytes Remove constraint Subject: CD8-positive T-lymphocytes
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1. CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier

Author:
Xia, Hong,   et al.   ; Liu, Zhaoxiang; Zhang, Hua; Wang, Baocheng; Zhang, Renwen; Zeng, Qun; Guo, Lingzhi; Shen, Kui; Wang, BaTa; Zhong, Yanheng; Li, Zhizhong; Sun, Guodong;     Show all 12 Authors
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:
... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:
10.1016/j.bbrc.2019.03.002