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Biochemical and biophysical research communications
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7982-2018
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2018 v.501 no.4
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- Author:
- Wenyu Jiao; Yongchen Wang; Linghong Kong; Tao Ou-yang; Qing Meng; Qiang Fu; Zhenzhen Hu
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 1016-1022
- ISSN:
- 0006-291X
- Subject:
- Alzheimer disease; adenosine triphosphate; animal models; antioxidant activity; antioxidants; apoptosis; caspase-3; caspase-9; hippocampus; memory; neurons; oxidative stress; peptides; rats; signal transduction; therapeutics
- Abstract:
- ... The accumulation of amyloid-beta (Aβ) and oxidative stress damage in the brain are recognized as early features of Alzheimer's disease (AD). The cocaine- and amphetamine-regulated transcript (CART) peptide may possibly play an antioxidative role in neurons. The aim of this study was to investigate the potential antioxidant mechanism of CART peptide in a rat model of AD. We microinjected of Aβ1-42 ...
- DOI:
- 10.1016/j.bbrc.2018.05.101
- https://doi.org/10.1016/j.bbrc.2018.05.101
- Author:
- Xiang Wang; Zeyuan Guan; Zhou Gong; Junjie Yan; Guangsheng Yang; Yao-Guang Liu; Ping Yin
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 898-904
- ISSN:
- 0006-291X
- Subject:
- copper; crystal structure; cytochrome-c oxidase; cytoplasmic male sterility; genes; hybrids; ion transport; mitochondria; models; plant breeding; protein structure; reactive oxygen species; rice; seeds
- Abstract:
- ... Plant cytoplasmic male sterility (CMS) is an important phenomenon and is widely utilized in hybrid crop breeding. The Wild Abortive CMS (CMS-WA), a well-known CMS type, has been successfully applied in the commercial production of hybrid rice seeds for more than 40 years. The CMS-WA causal gene WA352 encodes a novel transmenbrane protein and the interacts with the mitochondrial copper chaperone CO ...
- DOI:
- 10.1016/j.bbrc.2018.05.079
- https://doi.org/10.1016/j.bbrc.2018.05.079
- Author:
- Akiho Nakatani; Xuan Li; Junki Miyamoto; Miki Igarashi; Hitoshi Watanabe; Asuka Sutou; Keita Watanabe; Takayasu Motoyama; Nobuhiko Tachibana; Mitsutaka Kohno; Hiroshi Inoue; Ikuo Kimura
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 955-961
- ISSN:
- 0006-291X
- Subject:
- Bacteroidetes; Firmicutes; adipose tissue; adults; animal models; bile acids; blood glucose; dairy protein; fatty liver; glucagon-like peptide 1; high fat diet; insulin; intestinal microorganisms; intestines; lipogenesis; males; mice; mung beans; obesity; phenotype; protein isolates; ribosomal RNA; secretion; sequence analysis; weight gain
- Abstract:
- ... The 8-globulin-rich mung bean protein (MPI) suppresses hepatic lipogenesis in rodent models and reduces fasting plasma glucose and insulin levels in obese adults. However, its effects on mitigating high fat diet (HFD)-induced obesity and the mechanism underlying these effects remain to be elucidated. Herein, we examined the metabolic phenotype, intestinal bile acid (BA) pool, and gut microbiota of ...
- DOI:
- 10.1016/j.bbrc.2018.05.090
- https://doi.org/10.1016/j.bbrc.2018.05.090
- Author:
- Nanaka Kaneshiro; Ryosuke Imaoka; Masato Komai; Taku Kashiyama; Takashi Sakurai; Takashi Uehara; Nobumasa Takasugi
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 1023-1028
- ISSN:
- 0006-291X
- Subject:
- Alzheimer disease; amyloid; brain; cell lines; clones; enzymes; gene editing; metabolism; metabolites; mice; mutation; neurites; pathogenesis; patients; retinoic acid
- Abstract:
- ... Amyloid-β precursor protein (APP) correlates with the pathogenesis of certain brain diseases, such as Alzheimer disease (AD). APP is cleaved by several enzymes to produce APP metabolites, including the amyloid beta peptide (Aβ), which accumulates in the brain of AD patients. However, the exact functions of APP metabolites remain elusive. In this study, using genome editing technology, we mutated j ...
- DOI:
- 10.1016/j.bbrc.2018.05.102
- https://doi.org/10.1016/j.bbrc.2018.05.102
- Author:
- Edwin J. Wiest; Heather Jensen Smith; Michael A. Hollingsworth
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 858-862
- ISSN:
- 0006-291X
- Subject:
- cell viability; endoplasmic reticulum; humans; neoplasm cells; pancreatic neoplasms; spectral analysis
- Abstract:
- ... We discovered that SU11274, a class I c-Met inhibitor, fluoresces when excited by 488 nm laser light and showed rapid specific accumulation in distinct subcellular compartments. Given that SU11274 reduces cancer cell viability, we exploited these newly identified spectral properties to determine SU11274 intracellular distribution and accumulation in human pancreatic cancer cells. The aim of the st ...
- DOI:
- 10.1016/j.bbrc.2018.05.034
- https://doi.org/10.1016/j.bbrc.2018.05.034
- Author:
- Zhen-Hua Wu; Chen Lin; Chen-Chen Liu; Wei-Wei Jiang; Ming-Zhu Huang; Xin Liu; Wei-Jian Guo
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 1068-1073
- ISSN:
- 0006-291X
- Subject:
- angiogenesis; animal tissues; chromosomes; gain-of-function mutation; metastasis; microRNA; neoplasm cells; prognosis; stomach neoplasms; therapeutics
- Abstract:
- ... Dysregulation of microRNAs has been demonstrated to be involved in a variety of biological events related to cancer, including proliferation, metastasis, angiogenesis and immune escape. MiR-616-3p is located on the chromosome region 12q13.3, however, its potential role and clinical implications in gastric cancer remain poorly understood. The current study aimed to investigate the potential role of ...
- DOI:
- 10.1016/j.bbrc.2018.05.109
- https://doi.org/10.1016/j.bbrc.2018.05.109
- Author:
- Kiyoshi Yasui; Mai Izumida; Takeya Nakagawa; Yoshinao Kubo; Hideki Hayashi; Takashi Ito; Hiroaki Ikeda; Toshifumi Matsuyama
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 833-837
- ISSN:
- 0006-291X
- Subject:
- T-lymphocytes; adults; antiviral agents; binding sites; cell lines; cell proliferation; drug resistance; interferon regulatory factors; leukemia; lymphoma; neoplasm cells; proto-oncogenes
- Abstract:
- ... Interferon regulatory factor (IRF) 4 and the proto-oncogene c-Rel cooperate in growth and antiviral drug resistance of adult T-cell leukemia/lymphoma (ATLL). To elucidate the target of IRF4 and c-Rel in ATLL, we determined the simultaneous binding sites of IRF4 and c-Rel using ChIP-seq technology. Nine genes were identified within 2 kb of binding sites, including MIR3662. Expression of miR-3662 wa ...
- DOI:
- 10.1016/j.bbrc.2018.04.159
- https://doi.org/10.1016/j.bbrc.2018.04.159
- Author:
- Rajiv Kumar Jha; Priyanka Tare; Valakunja Nagaraja
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 877-884
- ISSN:
- 0006-291X
- Subject:
- DNA; DNA topoisomerase (ATP-hydrolysing); DNA-directed RNA polymerase; Mycobacterium tuberculosis; gene expression; homeostasis; operon; topology; transcription (genetics)
- Abstract:
- ... DNA gyrase introduces negative supercoils into DNA to maintain topological homeostasis. The genes encoding gyrase, gyrB and gyrA, form a dicistronic operon in Mycobacterium tuberculosis (Mtb) and other actinobacteria. Earlier work indicated that DNA relaxation stimulates the expression of the gyr genes, a phenomenon termed relaxation-stimulated transcription (RST). The present study addresses the ...
- DOI:
- 10.1016/j.bbrc.2018.05.067
- https://doi.org/10.1016/j.bbrc.2018.05.067
- Author:
- Bailing Dai; Na Qi; Junchao Li; Guilong Zhang
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 871-876
- ISSN:
- 0006-291X
- Subject:
- Western blotting; adjuvants; antibodies; brain neoplasms; cell lines; drug therapy; drugs; glioma; immunohistochemistry; immunotherapy; magnetic resonance imaging; mice; models; patients; spleen
- Abstract:
- ... Temozolomide (TMZ) is the most frequent adjuvant chemotherapy drug in gliomas. PDL1 expresses on various tumors, including gliomas, and anti-PD-1 antibodies have been approved for treating some tumors by FDA. This study was to evaluate the therapeutical potential of combined TMZ with anti-PD-1 antibody therapy for mouse orthotopic glioma model.We performed C57BL/6 mouse orthotopic glioma model by ...
- DOI:
- 10.1016/j.bbrc.2018.05.064
- https://doi.org/10.1016/j.bbrc.2018.05.064
- Author:
- Michele Tavanti; Joanne L. Porter; Colin W. Levy; J. Rubén Gómez Castellanos; Sabine L. Flitsch; Nicholas J. Turner
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 846-850
- ISSN:
- 0006-291X
- Subject:
- active sites; crystal structure; engineering; enzymes; fatty acids; guidelines; macrolides; models; sequence analysis; steroids; terpenoids
- Abstract:
- ... The first crystal structure of a class VII P450, CYP116B46 from Tepidiphilus thermophilus, has been solved at 1.9 Å resolution. The structure reveals overall conservation of the P450-fold and a water conduit around the I-helix. Active site residues have been identified and sequence comparisons have been made with other class VII enzymes. A structure similarity search demonstrated that the P450-TT ...
- DOI:
- 10.1016/j.bbrc.2018.05.014
- https://doi.org/10.1016/j.bbrc.2018.05.014
- Author:
- Norihiro Kotani; Yui Ida; Takanari Nakano; Izumi Sato; Ryusuke Kuwahara; Arisa Yamaguchi; Masahiro Tomita; Koichi Honke; Takayuki Murakoshi
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 982-987
- ISSN:
- 0006-291X
- Subject:
- Western blotting; animal models; blood serum; brain; enzyme-linked immunosorbent assay; humans; lung neoplasms; mice; patients; secretion; transgenic animals
- Abstract:
- ... Close homolog of L1 (CHL1) and its truncated form mainly play crucial roles in mouse brain development and neural functions. Herein, we newly identified that truncated form of CHL1 is produced and released from lung tumor tissue in a mouse model expressing human EML4-ALK fusion gene. Both western blot and direct ELISA analysis revealed that mouse CHL1 level in serum (including serum extracellular ...
- DOI:
- 10.1016/j.bbrc.2018.05.096
- https://doi.org/10.1016/j.bbrc.2018.05.096
- Author:
- Junrong Wang; Cong Ye; Junbao Liu; Yubo Hu
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 1034-1040
- ISSN:
- 0006-291X
- Subject:
- animal ovaries; apoptosis; carcinoma; drug resistance; non-coding RNA; oncogenes; ovarian neoplasms; paclitaxel; therapeutics
- Abstract:
- ... Increasing evidence has demonstrated the involvement of dysregulated long non-coding RNAs (lncRNAs) in chemoresistance acting as potential oncogenes or tumor suppressors in various cancers. Nevertheless, the profound molecular mechanisms of lncRNAs in ovarian cancer (OC) chemoresistance is not well elucidated. The objective of this work was to investigate the role and molecular mechanisms of uroth ...
- DOI:
- 10.1016/j.bbrc.2018.05.104
- https://doi.org/10.1016/j.bbrc.2018.05.104
- Author:
- Gulnaz Khan; Meha Fatima Aftab; Bilquees Bano; Khalid Mohammed Khan; Munazza Murtaza; Sonia Siddiqui; M.Hafizur Rehman; Rizwana Sanaullah Waraich
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 863-870
- ISSN:
- 0006-291X
- Subject:
- adipocytes; adiponectin; advanced glycation end products; age; animal disease models; blood serum; diabetes; glucose; glucose tolerance; glycogen; insulin; insulin receptor substrate proteins; insulin resistance; mechanism of action; mice; mitogen-activated protein kinase; muscle tissues; phosphorylation; reactive oxygen species; serine; transcription factor NF-kappa B
- Abstract:
- ... Accumulating evidence indicates that a number of tissues are damaged due to build-up of abnormal amount of Advanced Glycation End products (AGEs) in several diseases including diabetes. Currently AGE inhibitors are scarce in clinical use indicating a need for development of new anti-AGE agents. The aim of the current study is to identify the new AGE inhibitors and to decipher their mechanism of ac ...
- DOI:
- 10.1016/j.bbrc.2018.05.043
- https://doi.org/10.1016/j.bbrc.2018.05.043
- Author:
- Bin Ni; Jared S. Farrar; Shanshan Chen; Joseph C. Lownik; Francesco S. Celi
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 851-857
- ISSN:
- 0006-291X
- Subject:
- biochemical pathways; cell culture; droplet size; genes; lipids; mice; mitochondria; protein phosphorylation; protein synthesis; receptor protein-tyrosine kinase; transcription factors; white adipocytes
- Abstract:
- ... Adipocyte differentiation is a tightly regulated process which requires the sequential and organized expression of numerous genes and proteins. Phosphorylation of cytoplasmic proteins and key transcription factors represents a critical regulatory mechanism of the process leading to adipocyte maturation and modulation of associated metabolic pathways. Despite the recognition of the importance of pr ...
- DOI:
- 10.1016/j.bbrc.2018.05.021
- https://doi.org/10.1016/j.bbrc.2018.05.021
- Author:
- Masaki Nishikawa; Hiroshi Kimura; Naomi Yanagawa; Morgan Hamon; Peter Hauser; Lifu Zhao; Oak D. Jo; Norimoto Yanagawa
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 996-1002
- ISSN:
- 0006-291X
- Subject:
- blood serum; branching; cell aggregates; culture media; genetic markers; in vitro culture; keratinocytes; kidneys; mice; morphogenesis; stem cells
- Abstract:
- ... Kidney organoid is an emerging topic of importance for research in kidney development and regeneration. Conventional culture systems for kidney organoids reported thus far use culture media containing serum, which may compromise our understanding and the potential clinical applicability of the organoid system. In our present study, we tested two serum-free culture conditions and compared their sui ...
- DOI:
- 10.1016/j.bbrc.2018.05.098
- https://doi.org/10.1016/j.bbrc.2018.05.098
- Author:
- Seul-Gi Lee; Young Ae Joe
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 941-947
- ISSN:
- 0006-291X
- Subject:
- angiogenin; autophagy; bone marrow; chloroquine; cytokines; human umbilical vein endothelial cells; hypoxia; hypoxia-inducible factor 1; ischemia; secretion; small interfering RNA; stem cells; therapeutics; vascular endothelial growth factors
- Abstract:
- ... Mesenchymal stromal/stem cells (MSCs) have been promising source for regenerative cell therapy in ischemic diseases. To improve efficacy of MSC therapy, various priming methods have been developed, and hypoxic priming has been reported to enhance therapeutic efficacy of MSCs by increasing secretion level of growth factors and cytokines. Recently, it has been reported that bone marrow MSCs primed w ...
- DOI:
- 10.1016/j.bbrc.2018.05.086
- https://doi.org/10.1016/j.bbrc.2018.05.086
- Author:
- Kazuki Harada; Shoko Sada; Hidekazu Sakaguchi; Mai Takizawa; Rika Ishida; Takashi Tsuboi
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 1009-1015
- ISSN:
- 0006-291X
- Subject:
- actin; calcium; cell lines; estrogen receptors; exocytosis; glucagon-like peptide 1; immunocytochemistry; insulin secretion; islets of Langerhans; isoflavones; metabolites; mice; microfilaments; polymerization; soybeans
- Abstract:
- ... S-equol is one of gut bacterial metabolites produced from soybean isoflavone daizein. While S-equol is known to promote glucose-induced insulin secretion from pancreatic β cells, whether S-equol affects glucagon-like peptide-1 (GLP-1) secretion from enteroendoceine L cells remains unclear. Here we assessed the effect of S-equol on GLP-1 secretion from mouse enteroendocrine L cell line GLUTag cells ...
- DOI:
- 10.1016/j.bbrc.2018.05.100
- https://doi.org/10.1016/j.bbrc.2018.05.100
- Author:
- Kenichiro Matsuzaki; Miki Shinohara
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 1080-1084
- ISSN:
- 0006-291X
- Subject:
- DNA; DNA damage; DNA repair; cell cycle; consensus sequence; cytotoxicity; homologous recombination; non-specific serine/threonine protein kinase; phosphorylation; protein subunits; yeasts
- Abstract:
- ... A DNA double strand break (DSB) is one of the most cytotoxic DNA lesions, but it can be repaired by non-homologous end joining (NHEJ) or by homologous recombination. The choice between these two repair pathways depends on the cell cycle stage. Although NHEJ constitutes a simple re-ligation reaction, the regulatory mechanism(s) controlling its activity has not been fully characterized. Lif1 is a re ...
- DOI:
- 10.1016/j.bbrc.2018.05.111
- https://doi.org/10.1016/j.bbrc.2018.05.111
- Author:
- Ning Yu; Yun Tong; Danni Zhang; Shanshan Zhao; Xinli Fan; Lihui Wu; Hua Ji
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 838-845
- ISSN:
- 0006-291X
- Subject:
- active ingredients; aldosterone; animal models; embryotoxicity; gene expression regulation; gene ontology; genes; glyphosate; hippocampus; humans; mice; microRNA; microarray technology; neurons; neurotoxicity; prefrontal cortex; progeny; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; secretion; steroid metabolism
- Abstract:
- ... Glyphosate is the active ingredient in numerous herbicide formulations. The roles of glyphosate in embryo-toxicity and neurotoxicity have been reported in human and animal models. Recently, several studies have reported evidence linking neurodevelopmental disorders (NDDs) with gestational glyphosate exposure. However, the role of glyphosate in neuronal development is still not fully understood. Ou ...
- DOI:
- 10.1016/j.bbrc.2018.04.200
- https://doi.org/10.1016/j.bbrc.2018.04.200
- Author:
- Xin Fang; Keli Ge; Chao Song; YinLin Ge; JinYu Zhang
- Source:
- Biochemical and biophysical research communications 2018 v.501 no.4 pp. 927-932
- ISSN:
- 0006-291X
- Subject:
- Western blotting; autophagy; body length; chemokine CCL5; chemokine CX3CL1; chemokine CXCL12; electron microscopy; fluorescent antibody technique; gene expression regulation; genes; genotype; hypothalamus; inflammation; interleukin-1beta; interleukin-6; messenger RNA; mice; models; neuroglia; neurons; obesity; omega-3 fatty acids; polyunsaturated fatty acids; quantitative polymerase chain reaction; transcription factor NF-kappa B; transgenic animals; tumor necrosis factor-alpha
- Abstract:
- ... Fat-1 transgenic mice were used as a model to study the effect of endogenous n-3 polyunsaturated fatty acids (n-3PUFAs) on the body weight, inflammatory factors and autophagy proteins in hypothalamus to explore the mechanism of n-3PUFAs inhibiting obesity.The mice were divided into two groups after genotype identification: fat-1 transgenic mice and wild-type mice. The body weight and body length o ...
- DOI:
- 10.1016/j.bbrc.2018.05.084
- https://doi.org/10.1016/j.bbrc.2018.05.084