U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Journal name Biochemical and biophysical research communications Remove constraint Journal name: Biochemical and biophysical research communications Publication year rev 7983-2017 Remove constraint Publication year rev: 7983-2017 Source 2017 Remove constraint Source: 2017
Start Over

Search

1,139  Search Results

« Previous | 1 - 20 of 1,139 |
Number of results to display per page

Search Results

1. 2,3-Butandione 2-monoxime inhibits skeletal myosin II by accelerating ATP cleavage

Author:
Hideyuki Komatsu; Yuji Koseki; Takeshi Kanno; Shunsuke Aoki; Takao Kodama
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
acetylcholinesterase; adenosine; adenosine triphosphate; adenosinetriphosphatase; mechanism of action; myosin; nuclear magnetic resonance spectroscopy; phosphorus; potassium; stable isotopes
Abstract:
... 2,3-Butandione 2-monoxime (BDM) is a widely used myosin inhibitor with an unclear mode of action. In this report, we investigated the mechanism of BDM oxime group nucleophilic reactivity on the phosphoester bond of ATP. BDM increased the ATPase activity of skeletal myosin subfragment 1 (S1) under conditions in which ATP cleavage is the rate-limiting step (K+, EDTA-ATPase activity of native S1 and ...
DOI:
10.1016/j.bbrc.2017.06.130

2. 4-PBA reverses autophagic dysfunction and improves insulin sensitivity in adipose tissue of obese mice via Akt/mTOR signaling

Author:
Qinyue Guo; Lin Xu; Huixia Li; Hongzhi Sun; Shufang Wu; Bo Zhou
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
adipocytes; adipose tissue; animal disease models; autophagy; butyric acid; endoplasmic reticulum; glucose tolerance; insulin; insulin resistance; mice; obesity; protective effect; small interfering RNA
Abstract:
... 4-phenyl butyric acid (4-PBA) has been considered as a key regulator of insulin resistance in obesity. However the mechanism of 4-PBA involved in insulin resistance remains elusive.We evaluated the effect of 4-PBA on abnormal autophagy and endoplasmic reticulum (ER) stress in obese mice. 4-PBA was administered in obese mice and adipocyte models, and metabolic parameters, autophagy markers, ER stre ...
DOI:
10.1016/j.bbrc.2017.01.106

3. A causal relationship between the neurotherapeutic effects of miR182/7a and decreased expression of PRDM5

Author:
Weiqi Ling; Xu Xu; Jinbo Liu
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Western blotting; animal injuries; apoptosis; correlation; flow cytometry; gene expression; gene expression regulation; luciferase; messenger RNA; models; necrosis; neurons; protein synthesis; quantitative polymerase chain reaction; rats; spinal cord; therapeutics; transfection
Abstract:
... Spinal cord injury (SCI) is terrible damage resulting in the deficiencies and necrosis of neurology and causes infinite inconvenience to sufferers. The therapy of SCI still meets a larger number of problems. Therefore, the underlying mechanism and novel therapy of acute SCI (ASCI) are urgent to explore.The SCI model was established in rats. The expression of miR-182/miR-7a and PRDM5 at mRNA level ...
DOI:
10.1016/j.bbrc.2017.05.141

4. A label-free immunoassay for Flavivirus detection by the Reflective Phantom Interface technology

Author:
Giovanni Tagliabue; Valentina Faoro; Serena Rizzo; Daniele Sblattero; Andrea Saccani; Gabriele Riccio; Tommaso Bellini; Matteo Salina; Marco Buscaglia; Alessandro Marcello
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Tick-borne encephalitis virus; West Nile virus; antibodies; cross reaction; diagnostic techniques; geographical distribution; immunoassays; microarray technology; monitoring; point-of-care systems; proteins; serology; travel; viremia
Abstract:
... Flaviviruses are widespread and cause clinically relevant arboviral diseases that impact locally and as imported travel-related infections. Direct detection of viraemia is limited, being typically undetectable at onset of symptoms. Therefore, diagnosis is primarily based on serology, which is complicated by high cross-reactivity across different species. The overlapping geographical distribution o ...
DOI:
10.1016/j.bbrc.2017.05.025

5. A new role of GCN2 in the nucleolus

Author:
Akito Nakamura; Hiromichi Kimura
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
DNA-directed RNA polymerase; amino acids; cell nucleolus; cytosol; fluorescent antibody technique; messenger RNA; nutrient deficiencies; ribosomal RNA; ribosomes; starvation; transfer RNA
Abstract:
... General control nonderepressible 2 (GCN2) is activated by the accumulation of uncharged tRNA in response to amino acid shortage and regulates amino acid starvation response in the cytosol. Here we report the nucleolar localization of GCN2 and the association between GCN2 and small RNA transcripts. Immunofluorescence analysis revealed that GCN2 was constitutively localized to the nucleolus or recru ...
DOI:
10.1016/j.bbrc.2017.02.038

6. A novel conformation of the LC3-interacting region motif revealed by the structure of a complex between LC3B and RavZ

Author:
Do Hoon Kwon; Leehyeon Kim; Byeong-Won Kim; Jun Hoe Kim; Kyung-Hye Roh; Eui-Ju Choi; Hyun Kyu Song
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Legionella pneumophila; autophagy; binding capacity; chemical elements; crystal structure; hydrophobicity; pathogens; proteins; tandem repeat sequences
Abstract:
... LC3-family member proteins play a critical role in autophagy, a cellular process responsible for the degradation of massive cellular components including intracellular pathogens. A variety of molecules involved in the autophagic pathway engage in specific interactions with a unique sequence motif referred to as the LIR (LC3-interacting region) motif. Although identification of conserved structural ...
DOI:
10.1016/j.bbrc.2017.06.173

7. A novel role for earthworm peptide Lumbricusin as a regulator of neuroinflammation

Author:
Minchul Seo; Joon Ha Lee; Minhee Baek; Mi-Ae Kim; Mi-Young Ahn; Seong Hyun Kim; Eun-Young Yun; Jae-Sam Hwang
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Lumbricus terrestris; antimicrobial peptides; cell viability; central nervous system; cytotoxicity; earthworms; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; macrophages; mitogen-activated protein kinase; neurodegenerative diseases; neuroglia; neurons; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Recently, we reported that Lumbricusin, an antimicrobial peptide isolated from earthworm Lumbricus terrestris, enhanced neuronal proliferation and ameliorated motor dysfunction and dopaminergic neurodegeneration. Accumulating evidence suggests that neurodegeneration is the primary pathological feature of acute or chronic inflammation mediated by microglia, the resident macrophage of the central ne ...
DOI:
10.1016/j.bbrc.2017.06.154

8. A self-assembled polyjuglanin nanoparticle loaded with doxorubicin and anti-Kras siRNA for attenuating multidrug resistance in human lung cancer

Author:
Zhong-Mei Wen; Jing Jie; Yuan Zhang; Han Liu; Li-Ping Peng
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Juglans mandshurica; P-glycoproteins; antibiotics; antineoplastic activity; cell proliferation; cytotoxicity; disease course; doxorubicin; genes; glycosides; hulls; humans; lung neoplasms; mice; multiple drug resistance; nanoparticles; neoplasm cells; particle size; small interfering RNA; survival rate; walnuts; zeta potential
Abstract:
... Lung cancer is a leading cause of cancer-associated mortality worldwide, which has a low survival rate. Multidrug resistance (MDR) is a major obstacle that hinders the treatment of lung cancer. Doxorubicin (DOX) is an anthracycline glycoside antibiotic, having a broad spectrum of anticancer activity against various solid tumors. Juglanin is a natural production, mainly extracted from green walnut ...
DOI:
10.1016/j.bbrc.2017.09.132

9. A serum exosomal microRNA panel as a potential biomarker test for gastric cancer

Author:
Ning Wang; Lina Wang; Yongjun Yang; Li Gong; Bin Xiao; Xin Liu
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
quantitative polymerase chain reaction; proteins; blood serum; stomach neoplasms; biomarkers; models; reverse transcriptase polymerase chain reaction; exosomes; metastasis; microRNA; neoplasm cells; patients; screening
Abstract:
... The findings from several studies have suggested that circulating miRNAs are imbalanced with the genesis of gastric cancer (GC). Both normal and cancer cells can generate and secrete exosomes, which are nanosized membrane vesicles that can transport microRNAs and proteins. Emerging evidence indicates that the exosomes secreted by cancer cells can be released into the circulatory system. In this st ...
DOI:
10.1016/j.bbrc.2017.10.003

10. A simple comparison of the extrinsic noise in gene expression between native and foreign regulations in Escherichia coli

Author:
Bei-Wen Ying; Shigeto Seno; Hideo Matsuda; Tetsuya Yomo
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Escherichia coli; clones; data collection; gene expression; gene expression regulation; genes
Abstract:
... Living cells reorganize their gene expression through regulatory machineries in response to external perturbations. The contribution of the regulation to the noise in gene expression is of great interest. In this study, we evaluate the contribution of both native and foreign regulations to the extrinsic noise in gene expression. We analyzed the gene expression data of a mini-library containing 70 ...
DOI:
10.1016/j.bbrc.2017.03.148

11. A simple elution strategy for biotinylated proteins bound to streptavidin conjugated beads using excess biotin and heat

Author:
Joleen S. Cheah; Soichiro Yamada
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
biotin; heat; mutants; precipitin tests; protein-protein interactions; streptavidin
Abstract:
... Protein-protein interactions are the molecular basis of cell signaling. Recently, proximity based biotin identification (BioID) has emerged as an alternative approach to traditional co-immunoprecipitation. In this protocol, a mutant biotin ligase promiscuously labels proximal binding partners with biotin, and resulting biotinylated proteins are purified using streptavidin conjugated beads. This ap ...
DOI:
10.1016/j.bbrc.2017.09.168
PubMed:
28986262
PubMed Central:
PMC5693302

12. A three-dimensional model of RNase P in the hyperthermophilic archaeon Pyrococcus horikoshii OT3

Author:
Xuzhu Gao; Kosuke Oshima; Toshifumi Ueda; Takashi Nakashima; Makoto Kimura
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Pyrococcus horikoshii; binding sites; crystal structure; double-stranded RNA; ions; magnesium; models; proteins; ribonucleases; transfer RNA
Abstract:
... Ribonuclease P (RNase P) is an endoribonuclease involved in maturation of the 5′-end of tRNA. We found previously that RNase P in the hyperthermophilic archaeon Pyrococcus horikoshii OT3 consists of a catalytic RNase P RNA (PhopRNA) and five protein cofactors designated PhoPop5, PhoRpp21, PhoRpp29, PhoRpp30, and PhoRpp38. The crystal structures of the five proteins have been determined, a three-di ...
DOI:
10.1016/j.bbrc.2017.09.085

13. AG1296 enhances plaque stability via inhibiting inflammatory responses and decreasing MMP-2 and MMP-9 expression in ApoE−/− mice

Author:
Min Dong; Changping Zhou; Liang Ji; Bing Pan; Lemin Zheng
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
atherosclerosis; carotid arteries; gene expression regulation; histology; inflammation; interleukin-6; lipids; macrophages; metalloproteinases; mice; myocytes; phenotype; signal transduction; smooth muscle; stroke; surgery; thrombosis; tumor necrosis factor-alpha; tyrosine
Abstract:
... Atherosclerosis is a chronic process that progresses to unstable plaques. Plaque rupture leads to deleterious consequences such as acute coronary syndrome, thrombosis and stroke. AG1296 is a potent tyrosine kinase inhibitor which is able to block PDGF-PDGFR signaling pathway. This study aims to assess the effect of AG1296 on plaque stability and explore the potential mechanisms.Atherosclerotic pla ...
DOI:
10.1016/j.bbrc.2017.05.159

14. AKT2 deficiency induces retardation of myocyte development through EndoG-MEF2A signaling in mouse heart

Author:
Dandan Chen; Fan Chen; Yitao Xu; Yubin Zhang; Zhe Li; Han Zhang; Tianshu Pan; Yuheng Su; Miyang Wan; Xiaochuan Wang; Junmei Ye
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
animal models; blood pressure; cardiac output; cardiomyocytes; hypertrophy; metabolism; mice; protein kinases; signal transduction
Abstract:
... Protein kinase B2 (AKT2) is implicated in diverse process of cardiomyocyte signaling including survival and metabolism. However, the role of AKT2 in myocardium development and the signaling pathway is rarely understood. Therefore, we sought to determine the effect of AKT2 deletion on heart development and its downstream targets. By using experimental animal models and neonatal rat cardiomyocytes ( ...
DOI:
10.1016/j.bbrc.2017.09.149

15. AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway

Author:
Hisako Akatsuka; Shuhei Kuga; Kaori Masuhara; Odontuya Davaadorj; Chisa Okada; Yumi Iida; Yoshinori Okada; Nahoko Fukunishi; Takahiro Suzuki; Kazuyoshi Hosomichi; Masato Ohtsuka; Masafumi Tanaka; Ituro Inoue; Minoru Kimura; Takehito Sato
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
T-lymphocytes; autophagy; glycolysis; mitochondria
Abstract:
... Metabolic reprogramming contributes to dynamic alteration of cell functions and characteristics. In T cells, TCR-mediated signaling evokes metabolic reprogramming and autophagy. AMBRA1 is known to serve in the facilitation of autophagy and quality control of mitochondria, but the role of AMBRA1 in T cell metabolic alteration is unknown. Here, we show that AMBRA1, but not ATG7, plays a role in TCR- ...
DOI:
10.1016/j.bbrc.2017.08.019

16. ARID1A represses hepatocellular carcinoma cell proliferation and migration through lncRNA MVIH

Author:
Sheng Cheng; Lan Wang; Chuan-Huai Deng; Shi-Chun Du; Ze-Guang Han
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
cell proliferation; disease course; hepatoma; mutation; neoplasm cells; non-coding RNA; nucleotides; protein binding
Abstract:
... ARID1A, encoding the BAF250a subunit of SWI/SNF complex, has a high mutation frequency in numerous types of cancer. LncRNAs, a type of non-coding RNAs longer than 200 nucleotides, have been reported to interplay with SWI/SNF complex during cancer progression. However, whether the interaction between ARID1A and lncRNA affects hepatocellular carcinoma (HCC) still needs to be investigated. Here, we r ...
DOI:
10.1016/j.bbrc.2017.07.072

17. Activation and overexpression of Sirt1 attenuates lung fibrosis via P300

Author:
Zhilin Zeng; Sheng Cheng; Huilong Chen; Qinghai Li; Yinan Hu; Qi Wang; Xianying Zhu; Jun Wang
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
animal models; epigenetics; fibroblasts; fibrosis; fluorescent antibody technique; histone deacetylase; lungs; mice; pathophysiology; patients; respiratory tract diseases; signal transduction; transcription (genetics); transforming growth factor beta 1
Abstract:
... Persistent fibroblast activation is a predominant feature of idiopathic pulmonary fibrosis (IPF), but the transcriptional and epigenetic mechanisms controlling this process are not well understood. Silent information regulator type-1 (Sirt1) is a member of class Ⅲ histone deacetylase with important regulatory roles in a variety of pathophysiologic processes, but its role in fibrotic lung diseases ...
DOI:
10.1016/j.bbrc.2017.03.155

18. Activation of EphA1-Epha receptor axis attenuates diabetic nephropathy in mice

Author:
Yihui Li; Hongdan Yan; Feng Wang; Shanying Huang; Yun Zhang; Zhihao Wang; Ming Zhong; Wei Zhang
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
high fat diet; signal transduction; renal function; phosphorylation; mitogen-activated protein kinase; metabolites; Dependoparvovirus; fibrosis; glucose; insulin resistance; hyperglycemia; animal disease models; metabolism; diabetic nephropathy; mice; insulin; kidneys; histopathology; islets of Langerhans; receptor protein-tyrosine kinase; inflammation; therapeutics; streptozotocin; hypertrophy
Abstract:
... The Eph family of receptor tyrosine kinases serves as key modulators of various cellular functions, including inflammation, hypertrophy and fibrosis. Recent analyses have revealed that a member of the Eph family, EphA1, plays a pivotal role in regulating insulin metabolism and kidney injury. However, the importance of EphA1 in diabetic nephropathy has not been recognized. We established a diabetic ...
DOI:
10.1016/j.bbrc.2017.03.100

19. Activation of Wnt3α/β-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation

Author:
Jianshui Zhang; Junfeng Zhang; Cunfang Qi; Pengbo Yang; Xinlin Chen; Yong Liu
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
apoptosis; brain; endothelial cells; gene expression; ischemia; lithium chloride; messenger RNA; signal transduction
Abstract:
... Brain microvascular endothelial cells (BMECs) play vital roles in cerebral ischemia, during which many signal pathways mediate BMECs apoptosis. In this study, we explored the potential role of Wnt3α/β-catenin signal in BMECs apoptosis induced by ischemia. Here, we found that oxygen-glucose deprivation (OGD) could induce apoptosis of BMECs with Wnt3a mRNA expression decrease. Meanwhile, activation ...
DOI:
10.1016/j.bbrc.2017.03.130

20. Activation of transient receptor potential melastatin 7 (TRPM7) channel increases basal autophagy and reduces amyloid β-peptide

Author:
Hyun Geun Oh; Sungkwon Chung
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Alzheimer disease; amyloid; autophagy; calcium; mutants; neuropathology
Abstract:
... Cerebral accumulation of amyloid β-peptide (Aβ), which is produced from amyloid precursor protein (APP), is the primary cause of Alzheimer's disease (AD). Autophagy recycles cellular components and digests intracellular components including Aβ. The Ca2+- and Mg2+-permeable transient receptor potential melastatin 7 (TRPM7) channel underlies the constitutive Ca2+ influx in some cells. Since we alrea ...
DOI:
10.1016/j.bbrc.2017.08.163