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1. Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau

Author:
Shimizu, Taiki; Uchida, Chiyoko; Shimizu, Ritsuko; Motohashi, Hozumi; Uchida, Takafumi
Source:
Biochemical and biophysical research communications 2017 v.493 pp. 946-951
ISSN:
0006-291X
Subject:
cell lines; genes; isomerization; megakaryocytes; mice; microtubules; polymerization
Abstract:
... Here we show that Pin1, a peptidyl-prolyl cis/trans isomerase which catalyzes the isomerization of phosphorylated Ser/Thr-Pro, is a regulatory molecule of thrombopoiesis. We found that mice lacking the Pin1 gene (Pin1−⁄− mice) formed more megakaryocytes (MKs) than wild type mice (WT mice), and that the proplatelet formation of MKs was poorer in Pin1−⁄− mice than WT mice. Treatment of Meg-01 cells, ...
DOI:
10.1016/j.bbrc.2017.09.115

2. Dietary β-conglycinin prevents acute ethanol-induced fatty liver in mice

Author:
Ikaga, Reina; Li, Dongyang; Yamazaki, Tomomi
Source:
Biochemical and biophysical research communications 2017 v.493 pp. 542-547
ISSN:
0006-291X
Subject:
alcohol drinking; beta-conglycinin; casein; ethanol; fatty liver; genes; glucose; hyperlipidemia; lipogenesis; liver; liver cirrhosis; males; mice; obesity; peroxisome proliferator-activated receptors; soy protein; stearoyl-CoA desaturase; transcription (genetics); triacylglycerols
Abstract:
... Alcoholic fatty liver is the earliest stage of alcohol-induced liver disease leading to liver cirrhosis. β-Conglycinin, one of the soy proteins, is known to prevent non-alcoholic fatty liver, hyperlipidemia and obesity. Therefore, we examined whether β-conglycinin feeding has an effect on the prevention of acute ethanol-induced fatty liver in mice. Male C57BL/6J mice were fed with 20 energy% β-con ...
DOI:
10.1016/j.bbrc.2017.08.155

3. Modulation of RAB5A early endosome trafficking in response to KRas mediated macropinocytic fluxes in pancreatic cancer cells

Author:
Teske, Christian; Schweitzer, Christine; Palamidessi, Andrea; Aust, Daniela E.; Scita, Giorgio; Weitz, Jürgen; Welsch, Thilo
Source:
Biochemical and biophysical research communications 2017 v.493 pp. 528-533
ISSN:
0006-291X
Subject:
adenocarcinoma; biogenesis; cell lines; dextran; endosomes; epidermal growth factor; genes; mutants; neoplasm cells; pancreatic neoplasms; shrinkage
Abstract:
... KRAS is the key mutated gene in pancreatic ductal adenocarcinoma (PDAC). Emerging evidence indicates that KRas modulates endocytic uptake. The present study aimed to explore the fate of early endosomal trafficking under the control of KRas expression in PDAC.Surprisingly, PANC-1 cells lacking KRas exhibited significantly enlarged early and late endosomes containing internalized dextran and epiderm ...
DOI:
10.1016/j.bbrc.2017.08.157

4. Thyroidectomy stimulates glucagon-like peptide-1 secretion and attenuates hepatic steatosis in high-fat fed rats

Author:
Kang, Jong Yeon; Kim, Mikyung; Kang, Yuna; Lee, Wonmok; Ha, Tae Kyung; Seo, Ji Hae; Son, Young Gil; Ha, Eunyoung
Source:
Biochemical and biophysical research communications 2017 v.493 pp. 548-555
ISSN:
0006-291X
Subject:
appetite; beta catenin; blood serum; cholesterol; fatty liver; genes; glucagon-like peptide 1; glutamate-ammonia ligase; high density lipoprotein; high fat diet; hypothyroidism; insulin; liver; low density lipoprotein; obesity; rats; secretion; small intestine; thyroid hormones; triacylglycerols
Abstract:
... Thyroid hormones (THs) as a therapeutic intervention to treat obesity has been tried but the effect of THs on body weight and the mechanistic details of which are far from clear. This study was designed to determine and elucidate the mechanistic details of metabolic action of THs in high-fat diet (HFD) fed Sprague Dawley (SD) rats. Rats were made surgically hypothyroid (thyroidectomy, Thx). Body w ...
DOI:
10.1016/j.bbrc.2017.08.154

5. Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells

Author:
Fujimoto, Takahiro; Yaoi, Takeshi; Fushiki, Shinji; Itoh, Kyoko
Source:
Biochemical and biophysical research communications 2017 v.492 pp. 349-355
ISSN:
0006-291X
Subject:
brain; central nervous system diseases; dystrophin; gene expression; genes; muscular dystrophy; neurons; phosphorylation; ubiquitin
Abstract:
... The Dystrophin (Dp) gene is responsible for Duchenne muscular dystrophy (DMD), which is characterized by progressive muscular degeneration and variable degrees of cognitive impairment. Although Dp71 is the most abundant among the Dp isoforms in the brain, the regulatory mechanisms of the related expression levels have not been elucidated. In this study, we found that the constitutive expression le ...
DOI:
10.1016/j.bbrc.2017.08.108

6. Epstein-Barr virus-encoded latent membrane protein 1 induces epithelial to mesenchymal transition by inducing V-set Ig domain containing 4 (VSIG4) expression via NF-kB in renal tubular epithelial HK-2 cells

Author:
Kim, Seung-Mi; Oh, Se Won; Park, Sang Hyun; Hur, Dae Young; Hong, Seung-Woo; Han, Sang Youb
Source:
Biochemical and biophysical research communications 2017 v.492 no.3 pp. 316-322
ISSN:
0006-291X
Subject:
transcription factor NF-kappa B; cell movement; fibrosis; humans; epithelial cells; Betaretrovirus; transcription (genetics); membrane proteins; genes; kidney diseases; cell lines; epithelium; cell proliferation; Human gammaherpesvirus 4
Abstract:
... The epithelial to mesenchymal transition (EMT), a hallmark of chronic kidney disease, is a key event in the conversion from tubular epithelial cells to myofibroblasts in renal fibrosis. Epstein-Barr virus (EBV) is a γ-herpes oncovirus associated with chronic kidney disease. However, the relationship between EBV and the EMT process in renal tubular epithelial cells is not well understood. Among EBV ...
DOI:
10.1016/j.bbrc.2017.08.116

7. E3 ubiquitin ligase DTX4 is required for adipogenic differentiation in 3T3-L1 preadipocytes cell line

Author:
Wang, Zonggui; Dai, Zhong; Pan, Yaqiong; Wu, Simin; Li, Zhengli; Zuo, Changqing
Source:
Biochemical and biophysical research communications 2017 v.492 pp. 419-424
ISSN:
0006-291X
Subject:
Lentivirus; adipogenesis; beta catenin; cell lines; droplets; genes; lipids; messenger RNA; mitosis; protein synthesis; signal transduction; transcription factors; ubiquitin-protein ligase
Abstract:
... Deltex4 (DTX4) is a member of the Deltex family of proteins. To date several lines of evidences suggest that Deltex family of proteins is closely linked to cell development and cell differentiation. However, little is known about the role of DTX4 in adipogenic differentiation. In this study, we assessed the impact of DTX4 on adipogenic differentiation in vitro, we found that DTX4 protein expressio ...
DOI:
10.1016/j.bbrc.2017.08.083

8. miR-1236-3p suppresses the migration and invasion by targeting KLF8 in lung adenocarcinoma A549 cells

Author:
Bian, Tingting; Jiang, Daishan; Liu, Jian; Yuan, Xiaopeng; Feng, Jia; Li, Qian; Zhang, Qing; Li, Xiaoli; Liu, Yifei; Zhang, Jianguo
Source:
Biochemical and biophysical research communications 2017 v.492 pp. 461-467
ISSN:
0006-291X
Subject:
adenocarcinoma; carcinogenesis; cell lines; cell movement; correlation; epithelium; genes; lungs; microRNA; neoplasm cells; prognosis
Abstract:
... MicroRNAs (miRNAs) have a great effect on regulating tumor cell migration, invasion, proliferation and prognosis. However, the mechanism of miR-1236-3p on regulating carcinogenesis is still unknown. In this study, the expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue. In lung adenocarcinoma A549 cell line, miR-1236-3p decreased ability of cell i ...
DOI:
10.1016/j.bbrc.2017.08.074

9. Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and Sirt1

Author:
Ianni, Alessandro; Hoelper, Soraya; Krueger, Marcus; Braun, Thomas; Bober, Eva
Source:
Biochemical and biophysical research communications 2017 v.492 pp. 434-440
ISSN:
0006-291X
Subject:
genes; genomics; heterochromatin; histones; homologous recombination; loci; methyltransferases; ribosomal DNA; ribosomal RNA
Abstract:
... Maintenance of highly compact heterochromatin at ribosomal DNA (rDNA) segments is essential to prevent homologous recombination between rDNA repeats and for preserving genomic stability and nucleolar architecture. Here, we investigated the role of Sirtuin 7 (Sirt7) in the regulation of rDNA chromatin structure, rDNA repeat stability and nucleolar organization. We found that Sirt7 mediates heteroch ...
DOI:
10.1016/j.bbrc.2017.08.081

10. TIF1β is phosphorylated at serine 473 in colorectal tumor cells through p38 mitogen-activated protein kinase as an oxidative defense mechanism

Author:
Shen, Larina Tzu-Wei; Chou, Han-Yi E.; Kato, Mitsuyasu
Source:
Biochemical and biophysical research communications 2017 v.492 pp. 310-315
ISSN:
0006-291X
Subject:
DNA repair; bacteria; cell death; cell lines; cell viability; colorectal neoplasms; drug therapy; genes; hydrogen peroxide; metabolites; mitogen-activated protein kinase; neoplasm cells; phosphorylation; serine; stem cells
Abstract:
... TIF1β is a pleiotropic regulator of a diverse range of cellular processes such as DNA repair or gene repression in stem cells. This functional switch depends on phosphorylation at serine residue 473 and multiple pathways exist to accomplish this. However, the effects of exogenous reactive oxygen species (ROS) generated by bacterial flora and dietary metabolites in the colonic lumen or chemotherapy ...
DOI:
10.1016/j.bbrc.2017.08.117

11. Identification of three signaling molecules required for calcineurin-dependent monopolar growth induced by the DNA replication checkpoint in fission yeast

Author:
Kume, Kazunori; Hashimoto, Tomoyo; Suzuki, Masashi; Mizunuma, Masaki; Toda, Takashi; Hirata, Dai
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 883-889
ISSN:
0006-291X
Subject:
DNA replication; Schizosaccharomyces pombe; adenosinetriphosphatase; antiporters; calcium; calcium signaling; cell polarity; genes; interphase; microtubules; non-specific serine/threonine protein kinase
Abstract:
... Cell polarity is coordinately regulated with the cell cycle. Growth polarity of the fission yeast Schizosaccharomyces pombe transits from monopolar to bipolar during G2 phase, termed NETO (new end take off). Upon perturbation of DNA replication, the checkpoint kinase Cds1/CHK2 induces NETO delay through activation of Ca2+/calmodulin-dependent protein phosphatase calcineurin (CN). CN in turn regula ...
DOI:
10.1016/j.bbrc.2017.07.129

12. MicroRNA-125b-5p modulates the inflammatory state of macrophages via targeting B7-H4

Author:
Diao, Wenli; Lu, Lin; Li, Shan; Chen, Jiangning; Zen, Ke; Li, Limin
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 912-918
ISSN:
0006-291X
Subject:
T-lymphocytes; cell proliferation; cytokines; dexamethasone; genes; macrophages; messenger RNA; protein synthesis; secretion; tissues
Abstract:
... As a newly identified negative costimulatory molecule of B7 family, B7-H4 suppresses T cell function via inhibiting cell proliferation and cytokine secretion. Although B7-H4 mRNA is widely distributed in various tissues, its protein expression is strongly limited, suggesting B7-H4 may be regulated post-transcriptionally. However, the mechanism underlying the inducement of B7-H4 expression remains ...
DOI:
10.1016/j.bbrc.2017.07.135

13. Plant G-protein β subunits positively regulate drought tolerance by elevating detoxification of ROS

Author:
Liu, Changying; Xu, Yazhen; Long, Dingpei; Cao, Boning; Hou, Jiamin; Xiang, Zhonghuai; Zhao, Aichun
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 897-902
ISSN:
0006-291X
Subject:
G-proteins; Morus alba; Nicotiana tabacum; drought; drought tolerance; enzyme activity; free radicals; gene overexpression; genes; hydrogen peroxide; malondialdehyde; mulberries; mutants; peroxidase; proline; tobacco; transgenic plants; water stress
Abstract:
... Heterotrimeric guanine-nucleotide-binding proteins (G-proteins) consist of α, β and γ subunits and play important roles in response and tolerance to abiotic stresses in plants, but the function of the heterotrimeric G-protein β subunit in response to drought remains unclear. In the present study, the AGB1 mutants (agb1-2-1 and agb1-3-2) were more sensitive to drought than the wild-type. The overex ...
DOI:
10.1016/j.bbrc.2017.07.133

14. Fibroblast growth factor 21 plays an inhibitory role in vascular calcification in vitro through OPG/RANKL system

Author:
Cao, Fangying; Liu, Xiaoxiao; Cao, Xiangrong; Wang, Shaoping; Fu, Kun; Zhao, Yejing; Shen, Fang; Liu, Jinghua
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 578-586
ISSN:
0006-291X
Subject:
alkaline phosphatase; apoptosis; atherosclerosis; calcification; caspase-3; fibroblast growth factors; gene expression regulation; genes; ligands; metabolism; phosphatidylinositol 3-kinase; rats; smooth muscle; therapeutics; transcription (genetics); transcription factor NF-kappa B
Abstract:
... Vascular calcification is prevalent and associated with adverse outcome without available therapy. The benefits of fibroblast growth factor (FGF)-21 on metabolism and atherosclerosis make it a promising therapeutic agent for vascular calcification. We investigated the effects of FGF21 on vascular smooth muscle cell (VSMC) calcification by culturing rat VSMCs in a calcifying medium for 9days. FGF21 ...
DOI:
10.1016/j.bbrc.2017.07.160

15. Functional analysis of the promoters of the small GTPases RhoA and RhoB in embryonic stem cells

Author:
Nomikou, Eirini; Stournaras, Christos; Kardassis, Dimitris
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 754-759
ISSN:
0006-291X
Subject:
autoregulation; cell lines; embryonic stem cells; enzyme activity; genes; guanosinetriphosphatase; messenger RNA; mutagenesis; neoplasms; proteins; regulatory sequences; transcription (genetics)
Abstract:
... Small GTPases of the Rho subfamily have been implicated in many physiological and pathological processes in various cell types including embryonic stem cells (ESCs). In the present study we performed a functional analysis of the promoters of the RhoA and the RhoB genes in order to identify regulatory elements that are important for their transcriptional control in ESCs. We show that RhoA mRNA leve ...
DOI:
10.1016/j.bbrc.2017.07.114

16. Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation

Author:
Guo, Jun; Lam, Lloyd T.; Longenecker, Kenton L.; Bui, Mai H.; Idler, Kenneth B.; Glaser, Keith B.; Wilsbacher, Julie L.; Tse, Chris; Pappano, William N.; Huang, Tzu-Hsuan
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 681-686
ISSN:
0006-291X
Subject:
NAD (coenzyme); biosynthesis; cell death; cytotoxicity; fibrosarcoma; genes; heterozygosity; human cell lines; humans; metabolites; neoplasm cells; nicotinamide; nicotinamide phosphoribosyltransferase; point mutation; resistance mechanisms; sequence analysis
Abstract:
... Cancer cells have an unusually high requirement for the central and intermediary metabolite nicotinamide adenine dinucleotide (NAD+), and NAD+ depletion ultimately results in cell death. The rate limiting step within the NAD+ salvage pathway required for converting nicotinamide to NAD+ is catalyzed by nicotinamide phosphoribosyltransferase (NAMPT). Targeting NAMPT has been investigated as an anti- ...
DOI:
10.1016/j.bbrc.2017.07.143

17. Pah1p negatively regulates the expression of V-ATPase genes as well as vacuolar acidification

Author:
Sherr, Goldie Libby; LaMassa, Nicole; Li, Erxin; Phillips, Greg; Shen, Chang-Hui
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 693-700
ISSN:
0006-291X
Subject:
H-transporting ATP synthase; acidification; biosynthesis; enzyme activity; genes; homeostasis; inositols; phospholipids; quantitative polymerase chain reaction; vacuoles; yeasts
Abstract:
... In yeast, PAH1 plays an important role in cell homeostasis and lipid biosynthesis. PAH1 encodes for the PA phosphatase, Pah1p, which is responsible for de novo TAG and phospholipid synthesis. It has been suggested that the lack of Pah1p causes irregular vacuolar morphology and dysfunctional V-ATPase pump activity. However, the molecular connection between Pah1p and V-ATPase activity has remained u ...
DOI:
10.1016/j.bbrc.2017.07.127

18. Role of LncRNA TUG1 in intervertebral disc degeneration and nucleus pulposus cells via regulating Wnt/β-catenin signaling pathway

Author:
Chen, Jiang; Jia, Yu-Song; Liu, Gen-Zhe; Sun, Qi; Zhang, Fan; Ma, Sheng; Wang, Yong-Jun
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 668-674
ISSN:
0006-291X
Subject:
Western blotting; apoptosis; beta catenin; caspase-3; cell proliferation; enzyme-linked immunosorbent assay; genes; humans; intervertebral disks; lumbar spine; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; staining; tumor necrosis factor-alpha
Abstract:
... To investigate the role of TUG1 in intervertebral disc degeneration (IDD) and human nucleus pulposus cells (NPCs) via regulating Wnt/β-catenin pathway.The study collected nucleus pulposus (NP) tissue samples from 30 patients with lumbar disc herniation (LDH) (Case group) and 18 patients with lumbar spine trauma (Control group). NPCs induced by TNF-α in vitro were divided into Blank, Vector, TUG1, ...
DOI:
10.1016/j.bbrc.2017.07.146

19. The effects of IGF-1 on mouse spermatogenesis using an organ culture method

Author:
Yao, Jianfei; Zuo, Haiyang; Gao, Jun; Wang, Mingming; Wang, Dong; Li, Xiangdong
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 840-847
ISSN:
0006-291X
Subject:
apoptosis; cell cycle; culture media; gene ontology; genes; haploidy; insulin-like growth factor I; insulin-like growth factor I receptor; mice; organ culture; quantitative polymerase chain reaction; sequence analysis; spermatids; spermatogenesis; stem cells; testes; transcriptome
Abstract:
... Currently available organ culture methods can induce the differentiation of spermatogonial stem cells (SSCs) to spermatids in vitro, but the percentages of haploid cells and elongated spermatids are extremely low. The goal of this study was to test strategies to increase the differentiation rate of SSCs into elongated spermatids in vitro. RNA-seq was performed from forty round spermatids isolated ...
DOI:
10.1016/j.bbrc.2017.05.125

20. The wheat salinity-induced R2R3-MYB transcription factor TaSIM confers salt stress tolerance in Arabidopsis thaliana

Author:
Yu, Yuehua; Ni, Zhiyong; Chen, Quanjia; Qu, Yanying
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 642-648
ISSN:
0006-291X
Subject:
Arabidopsis thaliana; abscisic acid; breeding; crops; drought; gene overexpression; genes; plant development; salinity; salt stress; salt tolerance; stress tolerance; temperature; transcription (genetics); transcription factors; transgenic plants; wheat
Abstract:
... MYB transcription factors are a large family of proteins involved in plant development and responses to stress. In this study, the wheat salinity-induced R2R3-MYB transcription factor TaSIM was functionally characterized, with a focus on its role in salt stress tolerance. TaSIM protein enters the nucleus and binds to the MYB-binding site II motif. Expression analysis revealed that TaSIM was induce ...
DOI:
10.1016/j.bbrc.2017.07.150