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You searched for: Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Publication Year 2017 Remove constraint Publication Year: 2017 Subject genes Remove constraint Subject: genes Subject mice Remove constraint Subject: mice Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau

Author:
Shimizu, Taiki; Uchida, Chiyoko; Shimizu, Ritsuko; Motohashi, Hozumi; Uchida, Takafumi
Source:
Biochemical and biophysical research communications 2017 v.493 pp. 946-951
ISSN:
0006-291X
Subject:
cell lines; genes; isomerization; megakaryocytes; mice; microtubules; polymerization
Abstract:
... Here we show that Pin1, a peptidyl-prolyl cis/trans isomerase which catalyzes the isomerization of phosphorylated Ser/Thr-Pro, is a regulatory molecule of thrombopoiesis. We found that mice lacking the Pin1 gene (Pin1−⁄− mice) formed more megakaryocytes (MKs) than wild type mice (WT mice), and that the proplatelet formation of MKs was poorer in Pin1−⁄− mice than WT mice. Treatment of Meg-01 cells, ...
DOI:
10.1016/j.bbrc.2017.09.115

2. Dietary β-conglycinin prevents acute ethanol-induced fatty liver in mice

Author:
Ikaga, Reina; Li, Dongyang; Yamazaki, Tomomi
Source:
Biochemical and biophysical research communications 2017 v.493 pp. 542-547
ISSN:
0006-291X
Subject:
alcohol drinking; beta-conglycinin; casein; ethanol; fatty liver; genes; glucose; hyperlipidemia; lipogenesis; liver; liver cirrhosis; males; mice; obesity; peroxisome proliferator-activated receptors; soy protein; stearoyl-CoA desaturase; transcription (genetics); triacylglycerols
Abstract:
... Alcoholic fatty liver is the earliest stage of alcohol-induced liver disease leading to liver cirrhosis. β-Conglycinin, one of the soy proteins, is known to prevent non-alcoholic fatty liver, hyperlipidemia and obesity. Therefore, we examined whether β-conglycinin feeding has an effect on the prevention of acute ethanol-induced fatty liver in mice. Male C57BL/6J mice were fed with 20 energy% β-con ...
DOI:
10.1016/j.bbrc.2017.08.155

3. The effects of IGF-1 on mouse spermatogenesis using an organ culture method

Author:
Yao, Jianfei; Zuo, Haiyang; Gao, Jun; Wang, Mingming; Wang, Dong; Li, Xiangdong
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 840-847
ISSN:
0006-291X
Subject:
apoptosis; cell cycle; culture media; gene ontology; genes; haploidy; insulin-like growth factor I; insulin-like growth factor I receptor; mice; organ culture; quantitative polymerase chain reaction; sequence analysis; spermatids; spermatogenesis; stem cells; testes; transcriptome
Abstract:
... Currently available organ culture methods can induce the differentiation of spermatogonial stem cells (SSCs) to spermatids in vitro, but the percentages of haploid cells and elongated spermatids are extremely low. The goal of this study was to test strategies to increase the differentiation rate of SSCs into elongated spermatids in vitro. RNA-seq was performed from forty round spermatids isolated ...
DOI:
10.1016/j.bbrc.2017.05.125

4. Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung

Author:
Kim, Jung-Hwan; Yamaori, Satoshi; Tanabe, Tomotaka; Takagi, Mitsuhiro; Matsubara, Tsutomu; Okamoto, Minoru; Kimura, Shioko; Gonzalez, Frank J.
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 271-276
ISSN:
0006-291X
Subject:
abnormal development; animal models; apoptosis; cell adhesion; cell culture; cell lines; epithelial cells; epithelium; genes; glucose; knockout mutants; lipids; lungs; metabolism; mice; phenotype; phosphates; plasmids; promoter regions
Abstract:
... Peroxisome proliferator-activated receptor-γ (PPARγ) plays an important role in lipid and glucose metabolism. In this study, the function of PPARγ on lung development was investigated. Lung-specific Pparg conditional knockout mice (PpargΔLuEpC) were developed using Cre-Lox system. PpargΔLuEpC mice showed abnormal lung development with enlarged airspaces and followed by increase of apoptotic cells ...
DOI:
10.1016/j.bbrc.2017.07.113

5. A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis

Author:
Ito, Ryo; Sato, Ikuko; Tsujita, Tadayuki; Yokoyama, Atsushi; Sugawara, Akira
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 21-28
ISSN:
0006-291X
Subject:
adrenal glands; aldosterone; angiotensin II; animal disease models; antihypertensive agents; blood pressure; electrolytes; gene expression; gene expression regulation; genes; hypertension; messenger RNA; metabolism; mice; renin-angiotensin system; screening; secretion
Abstract:
... CYP11B2 is a key enzyme involved in the synthesis of the mineralocorticoid aldosterone. CYP11B2 expression in the adrenal glands is controlled by the renin-angiotensin system (RAS), and plays an important role in the maintenance of electrolyte metabolism in higher organisms. Abnormal overexpression of CYP11B2 results in the disruption of mineral balance and can lead to hypertension. Though the mol ...
DOI:
10.1016/j.bbrc.2017.05.109

6. BCL6 mediates the effects of Gastrodin on promoting M2-like macrophage polarization and protecting against oxidative stress-induced apoptosis and cell death in macrophages

Author:
Jia, Jing; Shi, Xiaojie; Jing, Xiaoqian; Li, Jianguo; Gao, Jie; Liu, Mengya; Lin, Chi-Iou; Guo, Xinzhi; Hua, Qian
Source:
Biochemical and biophysical research communications 2017 v.486 pp. 458-464
ISSN:
0006-291X
Subject:
B-cell lymphoma; Oriental traditional medicine; apoptosis; arginase; bioactive compounds; biomarkers; blood sampling; cerebral palsy; childhood; gene expression; gene expression regulation; genes; hydrogen peroxide; macrophages; messenger RNA; mice; microarray technology; oxidative stress; patients; prediction; protective effect; small interfering RNA; tissue repair
Abstract:
... Cerebral palsy (CP) is the most common childhood disability worldwide, yet biomarkers for predicting CP are lacking. By subjecting peripheral blood samples from 62 CP patients and 30 healthy controls to Affymetrix GeneChip® PrimeView™ HumanGene Expression Microarray analysis, we identified the novel biomarker B-cell lymphoma 6 (BCL6) as the most upregulated gene in the CP samples. Gastrodin is a t ...
DOI:
10.1016/j.bbrc.2017.03.062

7. Klotho ameliorates cyclosporine A–induced nephropathy via PDLIM2/NF-kB p65 signaling pathway

Author:
Jin, Meihua; Lv, Pengfei; Chen, Guanyu; Wang, Peng; Zuo, Zhongfu; Ren, Lili; Bi, Jing; Yang, Chul-Woo; Mei, Xifan; Han, Donghe
Source:
Biochemical and biophysical research communications 2017 v.486 pp. 451-457
ISSN:
0006-291X
Subject:
Adenoviridae; blood serum; creatinine; cyclosporine; dose response; epithelial cells; excretion; fibrosis; gene transfer; genes; humans; inducible nitric oxide synthase; inflammation; interleukin-12; interleukin-6; kidney diseases; longevity; luciferase; macrophages; messenger RNA; mice; oxidative stress; quantitative polymerase chain reaction; secretion; signal transduction; small interfering RNA; transcription factor NF-kappa B; tumor necrosis factor-alpha; urea nitrogen
Abstract:
... Klotho, an antiaging protein, can extend the lifespan and modulate cellular responses to inflammation and oxidative stress which can ameliorate chronic kidney diseases (CKD). To investigate the molecular mechanism of Klotho on inflammation in cyclosporine A (CsA) induced nephropathy, the mice were transfected with adenovirus mediated Klotho gene and treated with cyclosporine A (CsA; 30 mg/kg/day) ...
DOI:
10.1016/j.bbrc.2017.03.061

8. Suv39h2 deficiency ameliorates diet-induced steatosis in mice

Author:
Shao, Jing; Li, Luyang; Xu, Huihui; Yang, Lili; Bian, Yaoyao; Fang, Mingming; Xu, Yong
Source:
Biochemical and biophysical research communications 2017 v.485 pp. 658-664
ISSN:
0006-291X
Subject:
alanine transaminase; animal models; diet; droplets; genes; histones; inflammation; lipids; liver; liver cirrhosis; macrophages; metabolic diseases; methyltransferases; mice; pathogenesis; quantitative polymerase chain reaction; staining
Abstract:
... Steatosis is a prototypical metabolic disorder characterized by accumulation of lipid droplets in the liver, extensive hepatic inflammation, and, in advanced stages, accelerated liver fibrogenesis. The molecular mechanism underlying steatosis is not completely understood. In the present study we investigated the involvement of the histone methyltransferase Suv39h2 in the pathogenesis of steatosis. ...
DOI:
10.1016/j.bbrc.2017.02.093

9. NERP-2 regulates gastric acid secretion and gastric emptying via the orexin pathway

Author:
Namkoong, Cherl; Toshinai, Koji; Waise, T.M. Zaved; Sakoda, Hideyuki; Sasaki, Kazuki; Ueta, Yoichi; Kim, Min-Seon; Minamino, Naoto; Nakazato, Masamitsu
Source:
Biochemical and biophysical research communications 2017 v.485 pp. 409-413
ISSN:
0006-291X
Subject:
antagonists; atropine; energy expenditure; gastric acid; gastric emptying; genes; hypothalamus; mice; nerve tissue; peptides; rats; secretion; signal transduction
Abstract:
... Neuroendocrine regulatory peptide (NERP)-2 is derived from a distinct region of VGF, a neurosecretory protein originally identified as a product of a nerve growth factor-responsive gene in rat PC12 cells. Colocalization of NERP-2 with orexin-A in the lateral hypothalamus increases orexin-A-induced feeding and energy expenditure in both rats and mice. Orexigenic and anorectic peptides in the hypoth ...
DOI:
10.1016/j.bbrc.2017.02.064

10. Changes in photoperiod alter Glut4 expression in skeletal muscle of C57BL/6J mice

Author:
Tashiro, Ayako; Shibata, Satomi; Takai, Yusuke; Uchiwa, Tatsuhiro; Furuse, Mitsuhiro; Yasuo, Shinobu
Source:
Biochemical and biophysical research communications 2017 v.485 no.1 pp. 82-88
ISSN:
0006-291X
Subject:
adipose tissue; blood glucose; body weight; genes; glucose transporters; insulin; insulin resistance; locomotion; metabolism; mice; muscles; photoperiod; seasonal variation; skeletal muscle
Abstract:
... Seasonal changes in photoperiod influence body weight and metabolism in mice. Here, we examined the effect of changes in photoperiod on the expression of glucose transporter genes in the skeletal muscle and adipose tissue of C57BL/6J mice. Glut4 expression was lower in the gastrocnemius muscle of mice exposed to a short-duration day (SD) than those to a long-duration day (LD), with accompanying ch ...
DOI:
10.1016/j.bbrc.2017.02.023

11. Dysregulation of long noncoding RNAs in mouse testes and spermatozoa after exposure to cadmium

Author:
Gao, Fengxin; Zhang, Peng; Zhang, Hongyan; Zhang, Yunhui; Zhang, Yunwen; Hao, Qingyun; Zhang, Xiaoning
Source:
Biochemical and biophysical research communications 2017 v.484 pp. 8-14
ISSN:
0006-291X
Subject:
cadmium; databases; gene expression; gene expression regulation; genes; male fertility; males; messenger RNA; mice; non-coding RNA; reproductive toxicology; sequence analysis; spermatogenesis; spermatozoa; testes; transcriptomics
Abstract:
... There is increasing evidence that cadmium (Cd) exposure can cause male subfertility and even complete infertility in mammals. Long noncoding (lnc) RNAs are critical for spermatogenesis, and their dysregulation might lead to male infertility. However, whether they are involved in Cd-induced subfertility is unknown. Here we found that intraperitoneal exposure to Cd in mice led to male subfertility i ...
DOI:
10.1016/j.bbrc.2017.01.091

12. Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes

Author:
Taniguchi, Hiroaki; Okamuro, Shota; Koji, Misaki; Waku, Tsuyoshi; Kubo, Kaori; Hatanaka, Atsushi; Sun, Yimeng; Chowdhury, A.M. Masudul Azad; Fukamizu, Akiyoshi; Kobayashi, Akira
Source:
Biochemical and biophysical research communications 2017 v.484 pp. 176-183
ISSN:
0006-291X
Subject:
cerebellum; cerebral cortex; databases; gene expression; genes; homeostasis; mice; microarray technology; motor neurons; neurodegenerative diseases; proteasome endopeptidase complex; proteolysis; stem cells; transcription factors
Abstract:
... The transcription factor Nrf1 (NFE2L1) maintains protein homeostasis (proteostasis) by regulating the gene expression of proteasome subunits in response to proteasome inhibition. The deletion of the Nrf1 gene in neural stem/progenitor cells causes severe neurodegeneration due to the accumulation of ubiquitinated proteins in Purkinje cells and motor neurons (Nrf1 NKO mice). However, the molecular m ...
DOI:
10.1016/j.bbrc.2017.01.038

13. Rifampin suppresses osteoclastogenesis and titanium particle-induced osteolysis via modulating RANKL signaling pathways

Author:
Zhu, Liang; Kang, Hui; Guo, Chang-an; Fan, Wen-shuai; Wang, Yi-ming; Deng, Lian-fu; Yan, Zuo-qin
Source:
Biochemical and biophysical research communications 2017 v.484 pp. 64-70
ISSN:
0006-291X
Subject:
H-transporting ATP synthase; T-lymphocytes; acid phosphatase; bone resorption; cathepsin K; cell viability; colony-stimulating factors; dose response; genes; ligands; macrophages; mice; mitogen-activated protein kinase; models; osteoclasts; prostheses; rifampicin; signal transduction; staining; titanium; transcription factor NF-kappa B
Abstract:
... Wear particles liberated from the surface of prostheses are considered to be main reason for osteoclast bone resorption and that extensive osteoclastogenesis leads to peri-implant osteolysis and subsequent prosthetic loosening. The aim of this study was to assess the effect of rifampin on osteoclastogenesis and titanium (Ti) particle-induced osteolysis.The Ti particle-induced osteolysis mouse calv ...
DOI:
10.1016/j.bbrc.2017.01.071

14. Possible role of mitochondrial permeability transition pore in the pathogenesis of Huntington disease

Author:
Quintanilla, Rodrigo A.; Tapia, Cheril; Pérez, María José
Source:
Biochemical and biophysical research communications 2017 v.483 pp. 1078-1083
ISSN:
0006-291X
Subject:
adenosine triphosphate; apoptosis; calcium; cortex; dementia; energy metabolism; genes; heart; mice; mitochondria; models; mutants; neurodegenerative diseases; neurons; pathogenesis; patients; permeability; reactive oxygen species
Abstract:
... Huntington disease (HD) is a devastating neurological disorder that affects the striatum and cortex of patients. HD patients develop progressive motor dysfunction and psychiatric disturbances with gradual dementia. HD is caused by a pathological expansion of CAG repeats in the huntingtin gene that codifies for a protein called huntingtin (Htt), which principal function is not completely understood ...
DOI:
10.1016/j.bbrc.2016.09.054

15. Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease

Author:
Czeredys, Magdalena; Maciag, Filip; Methner, Axel; Kuznicki, Jacek
Source:
Biochemical and biophysical research communications 2017 v.483 pp. 1194-1205
ISSN:
0006-291X
Subject:
calcium; endoplasmic reticulum; extracellular space; genes; genetically modified organisms; homeostasis; membrane potential; mice; mitochondrial membrane; models; neurodegenerative diseases; neurons
Abstract:
... Huntington's disease (HD) is a hereditary neurodegenerative disease caused by a polyglutamine expansion within the huntingtin (HTT) gene. One of the cellular functions that is dysregulated in HD is store-operated calcium entry (SOCE), a process in which the depletion of Ca2+ from the endoplasmic reticulum (ER) induces Ca2+ influx from the extracellular space. We detected an enhanced activity of SO ...
DOI:
10.1016/j.bbrc.2016.08.106

16. Circadian clock and steroidogenic-related gene expression profiles in mouse Leydig cells following dexamethasone stimulation

Author:
Chen, Huatao; Gao, Lei; Xiong, Yongjie; Yang, Dan; Li, Cuimei; Wang, Aihua; Jin, Yaping
Source:
Biochemical and biophysical research communications 2017 v.483 pp. 294-300
ISSN:
0006-291X
Subject:
Leydig cells; bioinformatics; circadian rhythm; dexamethasone; fluorescent antibody technique; gene expression; genes; image analysis; liver; mice; transcription (genetics)
Abstract:
... Previous studies have shown that circadian clock genes are expressed in mammalian testes; however, it remains unclear if the expression patterns of these genes are cyclic. Furthermore, it is unknown whether Leydig cells, the primary androgen secreting cells in the testis, play a role in the rhythmicity of circadian clock and steroidogenic-related gene transcription. Here, we examine the circadian ...
DOI:
10.1016/j.bbrc.2016.12.149

17. Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: Differences between endogenous and exogenous insulin effects

Author:
Oishi, Katsutaka; Yasumoto, Yuki; Higo-Yamamoto, Sayaka; Yamamoto, Saori; Ohkura, Naoki
Source:
Biochemical and biophysical research communications 2017 v.483 pp. 165-170
ISSN:
0006-291X
Subject:
circadian rhythm; corticosterone; cultured cells; gene expression; genes; heart; insulin; liver; locomotion; mice; phosphorylation; skeletal muscle
Abstract:
... The master clock in the suprachiasmatic nucleus synchronizes peripheral clocks via humoral and neural signals in mammals. Insulin is thought to be a critical Zeitgeber (synchronizer) for peripheral clocks because it induces transient clock gene expression in cultured cells. However, the extent to which fluctuations in feeding-dependent endogenous insulin affect the temporal expression of clock gen ...
DOI:
10.1016/j.bbrc.2016.12.173

18. Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice

Author:
Montufar-Solis, Dina; Williams, Alexander; Vigneswaran, Nadarajah; Klein, John R.
Source:
Biochemical and biophysical research communications 2017 v.483 pp. 590-595
ISSN:
0006-291X
Subject:
T-lymphocytes; animal models; colon; epithelium; genes; inflammation; interferon-gamma; interleukin-17; messenger RNA; mice; mutation; small intestine; tumor necrosis factor-alpha; ubiquitin-protein ligase
Abstract:
... Roquin is an E3 ligase that regulates mRNA stability. Mice with a mutation in the Rc3h1 gene and Roquin protein, referred to as Roquinsan/san or sanroque mice, develop broad-spectrum chronic inflammatory conditions and autoimmune pathologies. Our laboratory recently reported that sanroque mice also develop extensive inflammation that is localized in the small intestine but is rare in the colon. He ...
DOI:
10.1016/j.bbrc.2016.12.099

19. Preserving expression of Pdx1 improves β-cell failure in diabetic mice

Author:
Yamamoto, Yuichi; Miyatsuka, Takeshi; Sasaki, Shugo; Miyashita, Kazuyuki; Kubo, Fumiyo; Shimo, Naoki; Takebe, Satomi; Watada, Hirotaka; Kaneto, Hideaki; Matsuoka, Taka-aki; Shimomura, Iichiro
Source:
Biochemical and biophysical research communications 2017 v.483 pp. 418-424
ISSN:
0006-291X
Subject:
animal disease models; diabetes; genes; glucose; glucose tolerance; histology; humans; insulin secretion; islets of Langerhans; messenger RNA; mice; reverse transcriptase polymerase chain reaction; transcription factors; transcriptional activation; transgenic animals
Abstract:
... Pdx1, a β-cell-specific transcription factor, has been shown to play a crucial role in maintaining β-cell function through transactivation of β-cell-related genes. In addition, it has been reported that the expression levels of Pdx1 are compromised under diabetic conditions in human and rodent models. We therefore aimed to clarify the possible beneficial role of Pdx1 against β-cell failure and gen ...
DOI:
10.1016/j.bbrc.2016.12.128

20. Protease–activated receptor 2 exacerbates adenine–induced renal tubulointerstitial injury in mice

Author:
Hayashi, Sakiko; Oe, Yuji; Fushima, Tomofumi; Sato, Emiko; Sato, Hiroshi; Ito, Sadayoshi; Takahashi, Nobuyuki
Source:
Biochemical and biophysical research communications 2017 v.483 pp. 547-552
ISSN:
0006-291X
Subject:
adenine; antagonists; atrophy; coagulation; diet; fibrin; fibrosis; genes; inflammation; kidney diseases; kidneys; mice; oxidative stress; pathogenesis
Abstract:
... Hypercoagulability is associated with chronic kidney disease (CKD). Tissue factor/factor VIIa complex and factor Xa in the coagulation cascade are known to activate protease–activated receptor 2 (PAR2), and to cause inflammation and tissue injury. Although PAR2 is highly expressed in the kidney, it is unclear whether PAR2 plays a pathogenic role in CKD. To test this, we fed the mice lacking Par2 ( ...
DOI:
10.1016/j.bbrc.2016.12.108