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21. Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway

Author:
Cui, Chao; Lin, Huang; Shi, Yanyu; Pan, Ruiyan
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 277-284
ISSN:
0006-291X
Subject:
adenosine; agonists; anaerobic conditions; apoptosis; endothelial cells; genes; humans; ischemia; membrane permeability; membrane potential; mitochondria; mitochondrial membrane; models; pro-apoptotic proteins; protective effect; purinergic receptors; signal transduction
Abstract:
... In recent years, many studies have demonstrated that endogenous adenosine induced by ischemia postconditioning reduces apoptosis in animal and cell models, but no study has clearly elucidated the effects of hypoxia postconditioning (HPC) in human dermal microvascular endothelial cells (HDMECs) of flaps, and the subtype of adenosine receptors involved remains unknown. In our study, we sought to ide ...
DOI:
10.1016/j.bbrc.2017.07.112

22. Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung

Author:
Kim, Jung-Hwan; Yamaori, Satoshi; Tanabe, Tomotaka; Takagi, Mitsuhiro; Matsubara, Tsutomu; Okamoto, Minoru; Kimura, Shioko; Gonzalez, Frank J.
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 271-276
ISSN:
0006-291X
Subject:
abnormal development; animal models; apoptosis; cell adhesion; cell culture; cell lines; epithelial cells; epithelium; genes; glucose; knockout mutants; lipids; lungs; metabolism; mice; phenotype; phosphates; plasmids; promoter regions
Abstract:
... Peroxisome proliferator-activated receptor-γ (PPARγ) plays an important role in lipid and glucose metabolism. In this study, the function of PPARγ on lung development was investigated. Lung-specific Pparg conditional knockout mice (PpargΔLuEpC) were developed using Cre-Lox system. PpargΔLuEpC mice showed abnormal lung development with enlarged airspaces and followed by increase of apoptotic cells ...
DOI:
10.1016/j.bbrc.2017.07.113

23. miR-203a controls keratinocyte proliferation and differentiation via targeting the stemness-associated factor ΔNp63 and establishing a regulatory circuit with SNAI2

Author:
Ma, Xu; Li, Ling; Jia, Tao; Chen, Mingwei; Liu, Guofeng; Li, Chunyang; Li, Ning; Yang, Daping
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 241-249
ISSN:
0006-291X
Subject:
apoptosis; calcium; cell cycle checkpoints; cell proliferation; dose response; genes; keratinocytes; luciferase; microRNA; prediction; promoter regions; transcription (genetics); transcription factors
Abstract:
... Keratinocyte differentiation plays a pivotal role in the function of epidermal barrier and can be triggered by extracellular calcium in vitro and in vivo, but the precise mechanism still need to be further investigated. On the other hand, it is known that microRNAs control multiple biological events including cellular proliferation and differentiation. The present study demonstrated that miR-203a ...
DOI:
10.1016/j.bbrc.2017.07.131

24. Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in vitro

Author:
Manivasagam, Senthamizharasi; Vellaichamy, Elangovan
Source:
Biochemical and biophysical research communications 2017 v.491 pp. 250-256
ISSN:
0006-291X
Subject:
Western blotting; cyclic GMP; enzyme-linked immunosorbent assay; fluorescent antibody technique; gene silencing; genes; genetic markers; isoproterenols; messenger RNA; protein synthesis; quantitative polymerase chain reaction
Abstract:
... Npr1 gene (coding for NPR-A) and Npr2 gene (coding for NPR-B) are identified as intrinsic anti-hypertrophic genes that opposes abnormal cardiac remodeling. However, the functional role of Npr1 and Npr2 genes during cardiac hypertrophic growth is not well understood. Hence, the present investigation was aimed to study the effect of Npr1 and Npr2 gene silencing, respectively on β-AR activation induc ...
DOI:
10.1016/j.bbrc.2017.07.123

25. Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells

Author:
Yamashita, Nobuko; Yashiro, Masato; Ogawa, Hirohito; Namba, Hikaru; Nosaka, Nobuyuki; Fujii, Yousuke; Morishima, Tsuneo; Tsukahara, Hirokazu; Yamada, Masao
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 466-471
ISSN:
0006-291X
Subject:
Influenza A virus; biochemical pathways; blood; cysteamine; epithelium; gene expression; genes; humans; influenza; interleukin-1beta; messenger RNA; metabolites; neoplasm cells; pantothenic acid; patients; pneumonia; respiratory system; transcription (genetics); tumor necrosis factor-alpha; virus replication
Abstract:
... Our previous analysis of gene expression profiles in the peripheral blood from patients with influenza A (H1N1) pdm09 pneumonia revealed elevated transcription levels of the vanin-1 (vascular non-inflammatory molecule 1, VNN1) gene, which encodes an epithelial ectoenzyme with pantetheinase activity involved in recycling coenzyme A. Here, to elucidate the role of VNN1 in influenza A virus (IAV) H1N ...
DOI:
10.1016/j.bbrc.2017.05.172

26. ERK1/2 signaling mediated naringin-induced osteogenic differentiation of immortalized human periodontal ligament stem cells

Author:
Wei, Kai; Xie, Yuansheng; Chen, Tianyu; Fu, Bo; Cui, Shaoyuan; Wang, Yan; Cai, Guangyan; Chen, Xiangmei
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 319-325
ISSN:
0006-291X
Subject:
alkaline phosphatase; bone formation; cell cycle; cell differentiation; gene overexpression; genes; genetic markers; humans; ligaments; longevity; mineralization; mitogen-activated protein kinase; naringin; osteocalcin; signal transduction; stem cells; transcription (genetics); transcription factors
Abstract:
... Periodontal ligament stem cells (PDLSCs) are promising tools for the investigations of cell differentiation and bone regeneration. However, the limited life span significantly restricts their usefulness. In this study, we established an immortalized PDLSC cell line by the introduction of Bmi1 (PDLSC-Bmi1). Several genes related to cell cycle, cell replication and stemness were found to be changed ...
DOI:
10.1016/j.bbrc.2017.05.130

27. NF-κB signaling and cell-fate decision induced by a fast-dissociating tumor necrosis factor mutant

Author:
Zhang, Xiaoling; Yin, Ning; Guo, Annan; Zhang, Qi; Zhang, Yalei; Xu, Youjun; Liu, Hongbo; Tang, Bo; Lai, Luhua
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 287-292
ISSN:
0006-291X
Subject:
apoptosis; caspases; dissociation; drugs; genes; mutants; transcription factor NF-kappa B; tumor necrosis factors
Abstract:
... Tumor necrosis factor (TNF) is a pluripotent inflammatory cytokine that can induce both the pro-survival nuclear factor kappa B (NF-κB) pathway and the pro-apoptotic caspase pathway. Selectively activating only one of the two pathways remains challenging. We used TNF mutants with different receptor binding kinetics to study their effects on NF-κB signaling dynamics and cell apoptosis. A TNF mutant ...
DOI:
10.1016/j.bbrc.2017.05.149

28. A transfer RNA gene rearrangement in the lepidopteran mitochondrial genome

Author:
Liu, Qiu-Ning; Xin, Zhao-Zhe; Zhu, Xiao-Yu; Chai, Xin-Yue; Zhao, Xiao-Ming; Zhou, Chun-Lin; Tang, Bo-Ping
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 149-154
ISSN:
0006-291X
Subject:
Bayesian theory; Parasa; amino acid sequences; genes; mitochondria; mitochondrial genome; models; moths; phylogeny; transfer RNA
Abstract:
... Gene arrangements in the mitochondrial genomes (mitogenomes) of insects are conserved across the major lineages, but can be rearranged within derived groups and may provide valuable phylogenetic characters. In this study, we sequenced the entire mitogenome of Parasa consocia, a moth of the family Limacodidae (Lepidoptera: Zygaenoidea). Compared with other lepidopterans and ancestral insects, the P ...
DOI:
10.1016/j.bbrc.2017.05.115

29. The occurrence of l-lactate dehydrogenase in the inner mitochondrial compartment of pig liver

Author:
Paventi, Gianluca; Pizzuto, Roberto; Passarella, Salvatore
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 255-261
ISSN:
0006-291X
Subject:
Sus scrofa; biomedical research; digitonin; genes; lactic acid; liver; metabolism; mitochondria; models; pH; solubilization; swine; temperature; titration
Abstract:
... Although pig represents a model species in biomedical research including studies dealing with liver patho-physiology, some aspects of liver metabolism need to be addressed. In particular, whether and how pig mitochondria can metabolize l-lactate remains to be established. We show here that pig liver mitochondria (PLM) possess their own l-lactate dehydrogenase (mL-LDH). This was shown both via immu ...
DOI:
10.1016/j.bbrc.2017.05.154

30. Whole-transcriptome screening reveals the regulatory targets and functions of long non-coding RNA H19 in epileptic rats

Author:
Han, Chun-Lei; Liu, Yun-Peng; Zhao, Xue-Min; Wang, Kai-Liang; Chen, Ning; Hu, Wei; Zhang, Jian-Guo; Ge, Ming; Meng, Fan-Gang
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 262-269
ISSN:
0006-291X
Subject:
animal models; apoptosis; cluster analysis; epilepsy; gene expression regulation; gene overexpression; genes; inflammation; microarray technology; mitogen-activated protein kinase; neuroglia; neurons; non-coding RNA; rats; screening; sprouting; transcription (genetics)
Abstract:
... Understanding the molecular mechanisms mediating epileptogenesis may lead to the development of preventative therapies against epilepsy. Our previous study demonstrated that the long non-coding RNA H19 contributes to epileptogenesis by aggravating status epilepticus-induced neuronal loss, glial cell activation, mossy fiber sprouting, and cognitive impairments in epileptic rats. However, the system ...
DOI:
10.1016/j.bbrc.2017.05.161

31. AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes

Author:
Wang, Hongbin; Quan, Haitian; Lou, Liguang
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 14-20
ISSN:
0006-291X
Subject:
antagonism; colorectal neoplasms; genes; heterozygosity; homozygosity; melanoma; mitogen-activated protein kinase; mutants; mutation; neoplasm cells; patients; phosphatidylinositol 3-kinase; signal transduction
Abstract:
... BRAF, one of the key factors in mitogen-activated protein kinase (MAPK) signaling pathway, plays an important role in cell functions including growth and proliferation. Inhibition of BRAF represents a promising antitumor strategy. Dabrafenib, a type I inhibitor of BRAF interrupting RAF/MEK interaction, has been approved by FDA as a single agent or combined with MEK inhibitor trametinib for the tre ...
DOI:
10.1016/j.bbrc.2017.05.110

32. A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis

Author:
Ito, Ryo; Sato, Ikuko; Tsujita, Tadayuki; Yokoyama, Atsushi; Sugawara, Akira
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 21-28
ISSN:
0006-291X
Subject:
adrenal glands; aldosterone; angiotensin II; animal disease models; antihypertensive agents; blood pressure; electrolytes; gene expression; gene expression regulation; genes; hypertension; messenger RNA; metabolism; mice; renin-angiotensin system; screening; secretion
Abstract:
... CYP11B2 is a key enzyme involved in the synthesis of the mineralocorticoid aldosterone. CYP11B2 expression in the adrenal glands is controlled by the renin-angiotensin system (RAS), and plays an important role in the maintenance of electrolyte metabolism in higher organisms. Abnormal overexpression of CYP11B2 results in the disruption of mineral balance and can lead to hypertension. Though the mol ...
DOI:
10.1016/j.bbrc.2017.05.109

33. Autophagy-related gene microarray and bioinformatics analysis for ischemic stroke detection

Author:
Guo, Yinsheng; Ma, Yue; Zhang, Yanwei; Zhou, Li; Huang, Suli; Wen, Ying; Zou, Fei; Cheng, Jinquan
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 48-55
ISSN:
0006-291X
Subject:
apoptosis; autophagy; bioinformatics; biomarkers; blood sampling; gene ontology; genes; lysosomes; microarray technology; mitochondria; morbidity; patients; prognosis; protein kinases; stroke
Abstract:
... Ischemic stroke (IS) is characterized by high morbidity and poor prognosis. However, the mechanisms of IS induced injury are still poorly understood. The main aim of this study is to explore the role of autophagy in IS. Ten pairs of whole blood samples of IS patients and matched controls were included to select differential expressed genes (DE genes) by autophagy-related functional gene microarray ...
DOI:
10.1016/j.bbrc.2017.05.099

34. The forkhead-like transcription factor (Fhl1p) maintains yeast replicative lifespan by regulating ribonucleotide reductase 1 (RNR1) gene transcription

Author:
Tai, Akiko; Kamei, Yuka; Mukai, Yukio
Source:
Biochemical and biophysical research communications 2017 v.488 pp. 218-223
ISSN:
0006-291X
Subject:
signal transduction; ribonucleotide reductase; precipitin tests; genes; catalytic activity; promoter regions; genetic factors; diploidy; longevity; transcription factors; gene overexpression; yeasts; eukaryotic cells; mutation; DNA microarrays; transcription (genetics); cell proliferation; heterozygosity; hydroxyurea; mutants; chromatin
Abstract:
... In eukaryotes, numerous genetic factors contribute to the lifespan including metabolic enzymes, signal transducers, and transcription factors. As previously reported, the forkhead-like transcription factor (FHL1) gene was required for yeast replicative lifespan and cell proliferation. To determine how Fhl1p regulates the lifespan, we performed a DNA microarray analysis of a heterozygous diploid st ...
DOI:
10.1016/j.bbrc.2017.05.038

35. Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells

Author:
Nakamura, Tamami; Hosoyama, Tohru; Murakami, Junichi; Samura, Makoto; Ueno, Koji; Kurazumi, Hiroshi; Suzuki, Ryo; Mikamo, Akihito; Hamano, Kimikazu
Source:
Biochemical and biophysical research communications 2017 v.487 pp. 653-659
ISSN:
0006-291X
Subject:
antagonists; antineoplastic agents; cell senescence; drug therapy; elderly; gene expression regulation; genes; heart; heart failure; humans; patients; phenotype; stem cells
Abstract:
... Aging of cardiac stem/progenitor cells (CSCs) impairs heart regeneration and leads to unsatisfactory outcomes of cell-based therapies. As the precise mechanisms underlying CSC aging remain unclear, the use of therapeutic strategies for elderly patients with heart failure is severely delayed. In this study, we used human cardiosphere-derived cells (CDCs), a subtype of CSC found in the postnatal hea ...
DOI:
10.1016/j.bbrc.2017.04.110

36. Disturbance of cell-size determination by forced overproduction of sulfoquinovosyl diacylglycerol in the cyanobacterium Synechococcus elongatus PCC 7942

Author:
Sato, Norihiro; Ebiya, Yuki; Kobayashi, Ryutaro; Nishiyama, Yoshitaka; Tsuzuki, Mikio
Source:
Biochemical and biophysical research communications 2017 v.487 pp. 734-739
ISSN:
0006-291X
Subject:
Synechococcus sp. PCC 7942; cell division; cell growth; diacylglycerols; gene overexpression; genes; homeostasis; messenger RNA; mutants; plastids
Abstract:
... Sulfoquinovosyl diacylglycerol (SQDG) is present in the membranes of cyanobacteria or their descendants, plastids at species-dependent levels. We investigated the physiological significance of the intrinsic SQDG content in the cyanobacterium Synechococcus elongatus PCC 7942, with the use of its mutant, in which the genes for SQDG synthesis, sqdB and sqdX, were overexpressed. The mutant showed a 1. ...
DOI:
10.1016/j.bbrc.2017.04.129

37. Evolutionary origins of pectin methylesterase genes associated with novel aspects of angiosperm pollen tube walls

Author:
Wallace, Simon; Williams, Joseph H.
Source:
Biochemical and biophysical research communications 2017 v.487 pp. 509-516
ISSN:
0006-291X
Subject:
Gymnospermae; Nymphaea odorata; eggs; esterification; evolution; gene expression; genes; pectinesterase; pectins; pollen; pollen tubes; spermatozoa; tissues; vascular plants
Abstract:
... The early evolution of angiosperms was marked by a number of innovations of the reproductive cycle including an accelerated fertilization process involving faster transport of sperm to the egg via a pollen tube. Fast pollen tube growth rates in angiosperms are accompanied by a hard shank-soft tip pollen tube morphology. A critical actor in that morphology is the wall-embedded enzyme pectin methyle ...
DOI:
10.1016/j.bbrc.2017.04.027

38. Identification of enzymes involved in the mevalonate pathway of Flavobacterium johnsoniae

Author:
Hayakawa, Hajime; Sobue, Fumiaki; Motoyama, Kento; Yoshimura, Tohru; Hemmi, Hisashi
Source:
Biochemical and biophysical research communications 2017 v.487 pp. 702-708
ISSN:
0006-291X
Subject:
Archaea; Flavobacterium johnsoniae; bacteria; biosynthesis; eukaryotic cells; genes; isoprenoids; phosphotransferases (kinases)
Abstract:
... The mevalonate pathway is prevalent in eukaryotes, archaea, and a limited number of bacteria. This pathway yields the fundamental precursors for isoprenoid biosynthesis, i.e., isopentenyl diphosphate and dimethylally diphosphate. In the downstream part of the general eukaryote-type mevalonate pathway, mevalonate is converted into isopentenyl diphosphate by the sequential actions of mevalonate kina ...
DOI:
10.1016/j.bbrc.2017.04.120

39. TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells

Author:
Eshelman, Melanie A.; Shah, Meera; Raup-Konsavage, Wesley M.; Rennoll, Sherri A.; Yochum, Gregory S.
Source:
Biochemical and biophysical research communications 2017 v.487 pp. 716-722
ISSN:
0006-291X
Subject:
T-lymphocytes; antagonists; binding proteins; carcinogenesis; cell cycle; cell growth; cell proliferation; colorectal neoplasms; gene expression; gene expression regulation; genes; histone deacetylase; humans; microarray technology; neoplasm cells; transcription factors
Abstract:
... The T-cell factor/Lymphoid enhancer factor (TCF/LEF; hereafter TCF) family of transcription factors are critical regulators of colorectal cancer (CRC) cell growth. Of the four TCF family members, TCF7L1 functions predominantly as a repressor of gene expression. Few studies have addressed the role of TCF7L1 in CRC and only a handful of target genes regulated by this repressor are known. By silencin ...
DOI:
10.1016/j.bbrc.2017.04.123

40. The mitogen-activated protein kinase kinase 9 (MKK9) modulates nitrogen acquisition and anthocyanin accumulation under nitrogen-limiting condition in Arabidopsis

Author:
Luo, Juan; Wang, Xu; Feng, Lei; Li, Yan; He, Jun-Xian
Source:
Biochemical and biophysical research communications 2017 v.487 pp. 539-544
ISSN:
0006-291X
Subject:
Arabidopsis; anthocyanins; genes; growth and development; mitogen-activated protein kinase kinase; nitrogen; plant adaptation; plant growth; transgenic plants
Abstract:
... Nitrogen (N) plays important roles as both a macronutrient and signal in plant growth and development. However, our understanding of N signaling and/or response mechanisms in plants is still limited. Here, we show that the mitogen-activated protein kinase kinase 9 (MKK9) is involved in plant N responses in Arabidopsis by regulating production of anthocyanins and the ability of N acquisition under ...
DOI:
10.1016/j.bbrc.2017.04.065