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You searched for: Author "Shi, Zheng" Remove constraint Author: "Shi, Zheng" Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Publication Year 2017 Remove constraint Publication Year: 2017
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1. Selenomethionine promoted hippocampal neurogenesis via the PI3K-Akt-GSK3β-Wnt pathway in a mouse model of Alzheimer's disease

Author:
Jia, Shi-Zheng,   et al.   ; Zheng, Rui; Zhang, Zhong-Hao; Chen, Chen; Chen, Yao; Liu, Qiong; Ni, Jia-Zuan; Song, Guo-Li;     Show all 8 Authors
Source:
Biochemical and biophysical research communications 2017 v.485 no.1 pp. 6-15
ISSN:
0006-291X
Subject:
Alzheimer disease; animal models; astrocytes; cognition; genetically modified organisms; in vitro studies; mice; neurodegenerative diseases; neurogenesis; neurons; selenium; selenomethionine; signal transduction; stem cells; tau-protein kinase; therapeutics
Abstract:
... The maintenance of neural system integrity and function is the ultimate goal for the treatment of neurodegenerative disease such as Alzheimer's disease (AD). Neurogenesis plays an integral role in the maintenance of neural and cognitive functions, and its dysfunction is regarded as a major cause of cognitive impairment in AD. Moreover, the induction of neurogenesis by targeting endogenous neural s ...
DOI:
10.1016/j.bbrc.2017.01.069