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- Author:
- Nam, Dae-Hwan; Han, Jung-Hwa; Kim, Suji; Shin, YoungHyun; Lim, Jae Hyang; Choi, Hyoung Chul; Woo, Chang-Hoon
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 622-628
- ISSN:
- 0006-291X
- Subject:
- AMP-activated protein kinase; apoptosis; calcium; cardiomyocytes; cardiomyopathy; diabetic complications; endoplasmic reticulum; epidemiological studies; gene expression; ischemia; protective effect; reactive oxygen species; signal transduction; stress response
- Abstract:
- ... Previous epidemiological studies have shown that methylglyoxal (MGO) levels are highly regulated in diabetic cardiovascular diseases. We have also previously reported that MGO mediates ER stress and apoptosis in cardiomyocytes. Furthermore, activated protein C (APC) has recently been shown to play a protective role against ER stress, as well as a cardioprotective role against ischemia and reperfus ...
- DOI:
- 10.1016/j.bbrc.2016.10.106
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.106
- Author:
- Chen, Lezi; Chen, Quan; Deng, Guosan; Kuang, Shifeng; Lian, Jihong; Wang, Mian; Zhu, Huilan
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 515-521
- ISSN:
- 0006-291X
- Subject:
- AMP-activated protein kinase; apoptosis; caspases; cell proliferation; cell viability; cytotoxicity; humans; melanocytes; melanoma; mice; mutation; severe combined immunodeficiency
- Abstract:
- ... Recent studies suggest that forced activation of AMP-activated protein kinase (AMPK) could inhibit melanoma cell proliferation. In this report, we evaluated the anti-melanoma cell activity by a novel small-molecular AMPK activator, GSK621. Treatment of GSK621 decreased survival and proliferation of human melanoma cells (A375, WM-115 and SK-Mel-2 lines), which was accompanied by activation of caspa ...
- DOI:
- 10.1016/j.bbrc.2016.10.040
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.040
- Author:
- Qin, Qin; Wang, Junhao; Yan, Yulin; Jing, Xiaodong; Du, Jianlin; Deng, Songbai; Wu, Ling; Liu, Yajie; She, Qiang
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 696-701
- ISSN:
- 0006-291X
- Subject:
- actin; angiotensin II; antagonists; carbachol; mice; muscles; myosin heavy chains; receptors; smooth muscle; stem cells
- Abstract:
- ... Epicardial progenitor cells (EpiCs) have a crucial role in cardiac development and vasculature formation. Here we detected the expression of Angiotensin II (Ang II) receptors AT1 and AT2 on EpiCs and demonstrated that AngII could increase the expression of smooth muscle specific markers, including α-smooth muscle actin (α-SMA) and myosin heavy chain 11 (Myh11) in EpiCs. Moreover, the expression of ...
- DOI:
- 10.1016/j.bbrc.2016.10.122
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.122
- Author:
- Wang, Ding; Peng, Yingpeng; Xie, Yangchun; Zhou, Borong; Sun, Xiaofang; Kang, Rui; Tang, Daolin
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 602-607
- ISSN:
- 0006-291X
- Subject:
- cell death; dopamine; dopamine receptors; gene expression; glutathione; immune system; iron; iron absorption; lipid metabolism; lipid peroxidation; malondialdehyde; neoplasms; neurodegenerative diseases; neurotransmitters; phospholipid-hydroperoxide glutathione peroxidase; phospholipids; protein degradation
- Abstract:
- ... Dopamine is a neurotransmitter that has many functions in the nervous and immune systems. Ferroptosis is a non-apoptotic form of regulated cell death that is involved in cancer and neurodegenerative diseases. However, the role of dopamine in ferroptosis remains unidentified. Here, we show that the non-oxidative form of dopamine is a strong inhibitor of ferroptotic cell death. Dopamine dose-depende ...
- DOI:
- 10.1016/j.bbrc.2016.10.099
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.099
- Author:
- Asada, Minoru; Mizutani, Shuki; Takagi, Masatoshi; Suzuki, Hidenori
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 615-621
- ISSN:
- 0006-291X
- Subject:
- antipsychotics; cultured cells; dopamine receptors; humans; in vitro studies; rodents; stem cells
- Abstract:
- ... We investigated the effects of antipsychotics on human induced pluripotent stem cell (hiPSC)-derived neural stem cell (NSC) differentiation. Induction of NSCs from hiPSCs was performed using PSC neural induction medium. Induced NSCs were subsequently cultured in neural differentiation medium containing antipsychotics. Cultured cells were subjected to neural differentiation marker analysis. As prev ...
- DOI:
- 10.1016/j.bbrc.2016.10.102
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.102
- Author:
- Ma, Yongyong; Lei, Huyi; Tan, Jie; Xuan, Li; Wu, Xiuli; Liu, Qifa
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 594-601
- ISSN:
- 0006-291X
- Subject:
- GATA transcription factors; T-lymphocytes; Toll-like receptor 8; immune response; myeloma; patients; remission
- Abstract:
- ... γδ regulatory T cells are able to inhibit the activation and function of T cells involved in antigen-specific immune responses. This study aimed to investigate the potential role of γδ regulatory T cells in inhibiting anti-tumor immune responses in patients diagnosed as multiple myeloma (MM). We measured the levels of γδ T cells, the distribution and clonally amplified TCR Vγ and VδT cells in peri ...
- DOI:
- 10.1016/j.bbrc.2016.10.098
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.098
- Author:
- Lee, Hankyu; Ko, Hyuk Wan
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 574-579
- ISSN:
- 0006-291X
- Subject:
- acetylation; animal development; antagonists; apoptosis; calcium; cilia; fibroblasts; genetic engineering; homeostasis; ligands; mice; microtubules; signal transduction; transcription factors; tubulin
- Abstract:
- ... Hedgehog (Hh) signaling plays key roles in animal development and tissue homeostasis. Binding of the secreted ligand to its Ptch1 receptor triggers Hh signaling through distinct canonical or noncanonical signaling pathways. Canonical Hh signaling leads to the activation of Gli transcription factors to induce Hh target-gene expression. In contrast, noncanonical Hh signaling regulates cytoskeleton r ...
- DOI:
- 10.1016/j.bbrc.2016.10.093
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.093
- Author:
- Aoyama, Michihiko; Hata, Katsutomo; Higashisaka, Kazuma; Nagano, Kazuya; Yoshioka, Yasuo; Tsutsumi, Yasuo
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 690-695
- ISSN:
- 0006-291X
- Subject:
- biological control; humans; nanoparticles; nanosilver; phagocytes; protein composition; proteins; silica
- Abstract:
- ... In biological fluids, nanoparticles interact with biological components such as proteins, and a layer called the “protein corona” forms around the nanoparticles. It is believed that the composition of the protein corona affects the cellular uptake and in vivo biodistribution of nanoparticles; however, the key proteins of the protein corona that control the biological fate of nanoparticles remain u ...
- DOI:
- 10.1016/j.bbrc.2016.10.121
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.121
- Author:
- Seiriki, Kaoru; Kasai, Atsushi; Kuwaki, Takahiro; Nakazawa, Takanobu; Yamaguchi, Shun; Hashimoto, Hitoshi
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 558-563
- ISSN:
- 0006-291X
- Subject:
- antagonists; mice; neurons; prefrontal cortex; receptors
- Abstract:
- ... Glutamatergic N-methyl-d-aspartate (NMDA) receptors play critical roles in several neurological and psychiatric diseases. Blockade by noncompetitive NMDA receptor antagonist leads to psychotomimetic effects; however, the brain regions responsible for the effects are not well understood. Here, we determined the specific brain regions responsive to MK-801, a noncompetitive NMDA receptor antagonist, ...
- DOI:
- 10.1016/j.bbrc.2016.10.089
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.089
- Author:
- Han, Xiaoni; Fang, Ziling; Wang, Heng; Jiao, Rongfang; Zhou, Jing; Fang, Nian
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 675-681
- ISSN:
- 0006-291X
- Subject:
- animal ovaries; carcinogenesis; cell proliferation; gene expression regulation; neoplasm cells; oncogenes; ovarian neoplasms; prognosis; small interfering RNA; tissues
- Abstract:
- ... Cullin 4A (CUL4A), as a well-defined oncogene, has been reported to be upregulated in ovarian cancer clinically. However, the biological functions of CUL4A and the molecular mechanism underlying its upregulation in ovarian cancer remains unknown throughly. Here, we show that expression of CUL4A is significantly higher in ovarian cancer tissues compared to corresponding non-cancerous tissues. Moreo ...
- DOI:
- 10.1016/j.bbrc.2016.10.114
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.114
- Author:
- Seth, Kunal; Harish,
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 499-507
- ISSN:
- 0006-291X
- Subject:
- RNA; chromosomes; crops; epigenetics; fluorescent dyes; gene expression; genes; genomics; image analysis
- Abstract:
- ... Redesigned Cas9 has emerged as a tool with various applications like gene editing, gene regulation, epigenetic modification and chromosomal imaging. Target specific single guide RNA (sgRNA) can be used with Cas9 for precise gene editing with high efficiency than previously known methods. Further, nuclease-deactivated Cas9 (dCas9) can be fused with activator or repressor for activation (CRISPRa) an ...
- DOI:
- 10.1016/j.bbrc.2016.10.130
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.130
- Author:
- Kim, Minsun; Kim, Eun-hee; Choi, Bo-Ran; Woo, Hee-Jong
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 734-740
- ISSN:
- 0006-291X
- Subject:
- cell growth; direct contact; gene expression; gene expression regulation; genes; iron; microarray technology; neurodegenerative diseases; prion diseases; prions
- Abstract:
- ... The conversion of the cellular prion protein (PrPC) to the protease-resistant isoform is the key event in chronic neurodegenerative diseases, including transmissible spongiform encephalopathies (TSEs). Increased iron in prion-related disease has been observed due to the prion protein-ferritin complex. Additionally, the accumulation and conversion of recombinant PrP (rPrP) is specifically derived f ...
- DOI:
- 10.1016/j.bbrc.2016.10.117
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.117
- Author:
- Zhang, Zhijian; Li, Zhengnan; Deng, Wenwen; He, Qinghua; Wang, Qiang; Shi, Wentao; Chen, Qian; Yang, Wenjing; Spector, Myron; Gong, Aihua; Yu, Jiangnan; Xu, Ximing
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 727-733
- ISSN:
- 0006-291X
- Subject:
- coculture; death; extracellular matrix; gap junctions; laminin; nervous system diseases; oligodendroglia; stem cells
- Abstract:
- ... Many neurological diseases are closely associated with demyelination caused by pathological changes of oligodendrocytes. Although intrinsic remyelination occurs after injury, the regeneration efficiency of myelinating oligodendrocytes remains to be improved. Herein, we reported an initiative finding of employing a valuable cell source, namely neural crest-derived ectoderm mesenchymal stem cells (E ...
- DOI:
- 10.1016/j.bbrc.2016.10.115
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.115
- Author:
- Kinana, Alfred D.; Vargiu, Attilio V.; Nikaido, Hiroshi
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 552-557
- ISSN:
- 0006-291X
- Subject:
- Escherichia coli; cephalosporins; drugs; hydrophobicity; minimum inhibitory concentration; mutants; site-directed mutagenesis; transporters
- Abstract:
- ... The Resistance-Nodulation-Division (RND) family transporter AcrB plays a major role in the intrinsic and increased resistance of Escherichia coli to a large number of antibiotics. The distal binding pocket within this multidrug efflux transporter is very large, but the effort to define the roles of various residues facing this pocket through site-directed mutagenesis so far involved only the deter ...
- DOI:
- 10.1016/j.bbrc.2016.10.083
- PubMed:
- 27789287
- PubMed Central:
- PMC5137507
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.083
- Author:
- Ujihara, Yoshihiro; Mohri, Satoshi; Katanosaka, Yuki
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 564-569
- ISSN:
- 0006-291X
- Subject:
- calcium; calcium channels; cardiomyocytes; heart failure; hypertrophy; quantitative analysis; sarcoplasmic reticulum; structural proteins
- Abstract:
- ... The Na+/Ca2+ exchanger 1 (NCX1) is an essential Ca2+ efflux system in cardiomyocytes. Although NCX1 is distributed throughout the sarcolemma, a subpopulation of NCX1 is localized to transverse (T)-tubules. There is growing evidence that T-tubule disorganization is a causal event that shifts the transition from hypertrophy to heart failure (HF). However, the detailed molecular mechanisms have not b ...
- DOI:
- 10.1016/j.bbrc.2016.10.090
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.090
- Author:
- Han, Yujin; An, Bobae; Choi, Sukwoo
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 608-614
- ISSN:
- 0006-291X
- Subject:
- cognition; fearfulness; hippocampus; memory
- Abstract:
- ... Mechanisms underlying delay fear conditioning in which conditioned stimuli (CS) are paired and co-terminated with unconditioned stimuli (US), have been extensively characterized, thus expanding knowledge concerning learning and memory. However, trace fear conditioning in which CS and US are separated by trace interval periods, has received much less attention though it involves cognitive processes ...
- DOI:
- 10.1016/j.bbrc.2016.10.101
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.101
- Author:
- Nagai, Saki; Ikeda, Kazuhiro; Horie-Inoue, Kuniko; Shiba, Sachiko; Nagasawa, Saya; Takeda, Satoru; Inoue, Satoshi
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 758-764
- ISSN:
- 0006-291X
- Subject:
- adenosine triphosphate; energy expenditure; estrogen receptors; exercise; females; gene expression regulation; mice; microarray technology; mitochondria; muscles; muscular diseases; ovariectomy; skeletal muscle
- Abstract:
- ... Estrogen is a hormone that regulates physiological processes and its dysregulation may relate to muscle disorders particularly in female, although the mechanism remains to be elucidated. We here show that estrogen deficiency repressed exercise endurance in female mice whereas the administration of estrogen to ovariectomized mice recovered it. Microarray analysis of mouse muscles showed that mitoch ...
- DOI:
- 10.1016/j.bbrc.2016.10.129
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.129
- Author:
- Osorio-Méndez, Juan Felipe; Vizcaíno-Castillo, Andrea; Manning-Cela, Rebeca; Hernández, Roberto; Cevallos, Ana María
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 709-714
- ISSN:
- 0006-291X
- Subject:
- Trypanosoma cruzi; actin; carbohydrate metabolism; gene expression; genes; insects; ligands; liquid chromatography; mammals; mass spectrometry; metalloproteinases; microtubules; parasites; profilins; regulatory proteins; sequence analysis
- Abstract:
- ... The role and regulation of actin in Trypanosoma cruzi and other related parasites is largely unknown. Based on early genome analysis, it was proposed that there was a reduced dependency on the acto-myosin system in the trypanosomatid parasites. However, more recent studies have extended the set of potential actin regulatory proteins, particularly for T. cruzi. One of the identified actin-binding p ...
- DOI:
- 10.1016/j.bbrc.2016.10.044
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.044
- Author:
- Lin, Jianhuang; Hisaoka, Miharu; Nagata, Kyosuke; Okuwaki, Mitsuru
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 702-708
- ISSN:
- 0006-291X
- Subject:
- bioluminescence; cell culture; luciferase; oligomerization; phosphoproteins; screening
- Abstract:
- ... NPM1/nucleophosmin is a multifunctional and oligomeric phosphoprotein. A number of observations have suggested that changes in the oligomer formation of NPM1 could influence its biological functions, especially its oncogenic functions. To understand the functional meaning of oligomerization of NPM1/nucleophosmin, we have established a novel method to monitor protein oligomerization in cells. We ut ...
- DOI:
- 10.1016/j.bbrc.2016.10.125
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.125
- Author:
- Zhu, Jianhua; Luo, Jing; Li, Yongchao; Jia, Min; Wang, Yueqin; Huang, Yan; Ke, Shuhong
- Source:
- Biochemical and biophysical research communications 2016 v.480 pp. 522-527
- ISSN:
- 0006-291X
- Subject:
- Toll-like receptor 4; carcinogenesis; cell movement; gene expression; humans; immigration; integrins; lung neoplasms; messenger RNA; metastasis; mice; neoplasm cells; non-specific protein-tyrosine kinase; nucleoproteins; phosphorylation; signal transduction; talin; transcription factor NF-kappa B
- Abstract:
- ... High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein with multi-functions and plays an important role in tumorigenesis and metastasis in various human cancers. In the present study, we found that HMGB1 induced migration of in human non-small cell lung cancer (NSCLC) cells by up-regulating integrin αvβ3 expression. Further investigation evidenced that HMGB1 activated Toll-like receptor ...
- DOI:
- 10.1016/j.bbrc.2016.10.052
-
http://dx.doi.org/10.1016/j.bbrc.2016.10.052
