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- Li, Liangchang; Jin, Guangyu; Jiang, Jingzhi; Zheng, Mingyu; Jin, Yan; Lin, Zhenhua; Li, Guangzhao; Choi, Yunho; Yan, Guanghai
- Biochemical and biophysical research communications 2016 v.473 pp. 408-414
- mast cells, etc ; Western blotting; anaphylaxis; calcium; cell viability; enzyme-linked immunosorbent assay; histamine; humans; immunoglobulin E; interleukin-6; intravenous injection; mitogen-activated protein kinase; rats; secretion; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha; Show all 17 Subjects
- ... The present study is to investigate the effect of cornuside on mast cell-mediated allergic response, as well as its possible mechanisms of action.To test the anti-allergic effects of cornuside in vivo, local extravasation was induced by local injection of anti-dinitrophenyl immunoglobulin E (IgE) followed by intravenous antigenic challenge in passive cutaneous anaphylaxis model rats. Mast cell via ...
- Zhang, Yuan-Yuan; Yu, Yang-Yang; Zhang, Ya-Rui; Zhang, Wei; Yu, Bo
- Biochemical and biophysical research communications 2016 v.470 pp. 368-374
- mast cells, etc ; Toll-like receptor 2; anti-infective properties; antimicrobial peptides; calcium; humans; inflammation; innate immunity; interleukin-8; ligands; mitogen-activated protein kinase; peptidoglycans; phosphatidylinositol 3-kinase; signal transduction; Show all 14 Subjects
- ... The sole and endogenous anti-microbial peptide LL-37 is a significant effector molecule in the innate host defense system. Apart from its broadly direct anti-microbial activity, the peptide also activates mast cell in respect of allergic diseases and inflammation. On the other hand, mast cell can be activated by Toll-like receptors (TLRs) which are at the center of innate immunity. It was the aim ...