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- Wang, Guangping, et al. Show all 5 Authors
- Biochemical and biophysical research communications 2016 v.472 pp. 662-668
- apoptosis; ceramides; cytotoxicity; humans; intraperitoneal injection; mice; mononuclear leukocytes; myeloid leukemia; neoplasm cells; sphingosine; stem cells
- ... Akt signaling plays a pivotal role in acute myeloid leukemia (AML) development and progression. In the present study, we evaluated the potential anti-AML activity by a novel Akt kinase inhibitor A-674563. Our results showed that A-674563 dose-dependently inhibited survival and proliferation of U937 AML cells and six lines of human AML progenitor cells, yet sparing human peripheral blood mononuclea ...