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- Ding, Wei, et al. Show all 8 Authors
- Biochemical and biophysical research communications 2015 v.459 pp. 361-366
- Parkinson disease; Western blotting; animal disease models; apoptosis; biosynthesis; brain; cell viability; cultured cells; diabetes mellitus; dopamine; glucose; human diseases; hyperglycemia; infrared spectroscopy; mice; mitochondria; mutants; neurons; neurotoxicity; neurotoxins; nuclear magnetic resonance spectroscopy; pathogenesis; patients; rats; risk; synthesis; transgenic animals
- ... Diabetes is associated with an increased risk of Parkinson's disease (PD). Number of studies have suggested that methylglyoxal (MGO) induced by diabetes is related to PD. However, very little is known about its molecular mechanism. On other hand, 1-acetyl-6, 7- dihydroxyl-1, 2, 3, 4- Tetrahydroisoquinoline(ADTIQ) is a dopamine (DA)-derived tetrahydroisoquinoline (TIQ), a novel endogenous neurotoxi ...