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- Chen, Lei, et al. Show all 6 Authors
- Biochemical and biophysical research communications 2015 v.464 pp. 487-492
- 3' untranslated regions; beta-galactosidase; cell senescence; humans; in vitro culture; protein synthesis; small interfering RNA; stem cells; telomerase; tissue degeneration; transfection; translation (genetics)
- ... Aging of tendon stem/progenitor cells (TSPCs) can lead to tissue degeneration and subsequent injury. However, the molecular mechanisms controlling TSPC aging are not completely understood. In the present study, we investigated the role of Pin1 in aging of human TSPCs. Pin1 mRNA and protein expression levels were significantly decreased during prolonged in vitro culture of human TSPCs. Furthermore, ...