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- Author:
- Liu, Ran-yi; Zhou, Ling; Zhang, Yan-ling; Huang, Bi-jun; Ke, Miao-la; Chen, Jie-min; Li, Li-xia; Fu, Xiang; Wu, Jiang-xue; Huang, Wenlin
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 171-176
- ISSN:
- 0006-291X
- Subject:
- anticarcinogenic activity; carcinoma; cytotoxicity; gene therapy; human umbilical vein endothelial cells; humans; neoplasm cells; proteins
- Abstract:
- ... A replication-deficient adenovirus (Ad) encoding secreted human endostatin (Ad-Endo) has been demonstrated to have promising antiangiogenic and antitumoral effects. The E1B55k-deleted Ad H101 can selectively lyse cancer cells. In this study, we explored the antitumor effects and cross-interactions of Ad-Endo and H101 on nasopharyngeal carcinoma (NPC). The results showed that H101 dramatically prom ...
- DOI:
- 10.1016/j.bbrc.2013.11.047
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.047
- Author:
- Kim, Eun Sung; Shin, Ji Hyun; Seok, Su Hyeon; Kim, Jun Bum; Chang, Huikyoung; Park, So Jung; Jo, Yoon Kyung; Choi, Eun Sun; Park, Jun-Seong; Yeom, Myeong Hun; Lim, Chol Seung; Cho, Dong-Hyung
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 165-170
- ISSN:
- 0006-291X
- Subject:
- autophagy; melanin; melanocytes; melanogenesis; melanoma; mitochondria; peroxisomes; screening
- Abstract:
- ... Autophagy is a cellular degradation process for cellular aggregates and unneeded cellular compartments including damaged mitochondria, ER, and peroxisomes. Melanosome is cellular organelle that is the cellular site of generation, storage and transports of melanin in melanocytes. Despite potential importance of autophagy, the role of autophagy in melanogenesis and melanosome autophagy are largely u ...
- DOI:
- 10.1016/j.bbrc.2013.11.048
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.048
- Author:
- Wang, Mengyao; Yuan, Feifei; Hao, Hongmei; Zhang, Yanfeng; Zhao, Huixian; Guo, Aiguang; Hu, Jingjiang; Zhou, Xiaona; Xie, Chang Gen
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 214-220
- ISSN:
- 0006-291X
- Subject:
- Arabidopsis; Brassica oleracea; abscisic acid; alternative splicing; cabbage; cytoplasm; drought; luciferase; phenotype; protein kinases; stomata; sucrose
- Abstract:
- ... Open Stomata 1 (OST1), an ABA-activated sucrose non-fermenting 1 (SNF1)-related protein kinase, is critical for plant drought responses. We investigated the functions of two splicing isoforms of the OST1 ortholog in Brassica oleracea (BolOST1). BolOST1 expression was found to be dramatically induced by drought and high-salt stress, and the ectopic expression of BolOST1 restored the drought-sensiti ...
- DOI:
- 10.1016/j.bbrc.2013.11.032
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.032
- Author:
- Okamoto, Mitsuhiro; Yamaoka, Mami; Takei, Masahiro; Ando, Tomomi; Taniguchi, Shigeki; Ishii, Isao; Tohya, Kazuo; Ishizaki, Toshimasa; Niki, Ichiro; Kimura, Toshihide
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 227-233
- ISSN:
- 0006-291X
- Subject:
- DNA fragmentation; apoptosis; blood glucose; chronic exposure; cystathionine gamma-lyase; gene expression regulation; genes; glucose; high fat diet; hydrogen; hydrogen sulfide; insulin; islets of Langerhans; mice; middle-aged adults; noninsulin-dependent diabetes mellitus
- Abstract:
- ... Chronic exposure to high glucose induces the expression of cystathionine gamma-lyase (CSE), a hydrogen sulfide-producing enzyme, in pancreatic beta-cells, thereby suppressing apoptosis. The aim of this study was to examine the effects of hydrogen sulfide on the onset and development of type 2 diabetes. Middle-aged (6-month-old) wild-type (WT) and CSE knockout (CSE-KO) mice were fed a high-fat diet ...
- DOI:
- 10.1016/j.bbrc.2013.11.023
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.023
- Author:
- Kim, Sun-Mi; Lee, Sae-A; Kim, Bo-Young; Bae, Sun-Sik; Eo, Seong-Kug; Kim, Koanhoi
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 159-164
- ISSN:
- 0006-291X
- Subject:
- T-lymphocytes; agonists; antibodies; arteries; atherosclerosis; chemokine CCL2; cholesterol; metabolites; mice; monocytes; secretion
- Abstract:
- ... Deposition of lipids in the intima is followed by infiltration of inflammatory cells, like monocytic cells and T lymphocytes, in atherosclerosis. However, roles of lipids in the infiltration of the inflammatory cells are not clearly defined. We investigated the possible involvement of cholesterol or its catabolites in recruitment of monocytic cells. Consumption of a high cholesterol-diet resulted ...
- DOI:
- 10.1016/j.bbrc.2013.11.052
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.052
- Author:
- Ohkuni, Aya; Ohno, Yusuke; Kihara, Akio
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 195-201
- ISSN:
- 0006-291X
- Subject:
- acyl coenzyme A; bioactive properties; biochemical pathways; endoplasmic reticulum; eukaryotic cells; genes; humans; ligases; metabolism; mutants; sphingosine; yeasts
- Abstract:
- ... Sphingosine 1-phosphate (S1P) plays important roles both as a bioactive lipid molecule and an intermediate of the sphingolipid-to-glycerophospholipid metabolic pathway. To identify human acyl-CoA synthetases (ACSs) involved in S1P metabolism, we cloned all 26 human ACS genes and examined their abilities to restore deficient sphingolipid-to-glycerophospholipid metabolism in a yeast mutant lacking t ...
- DOI:
- 10.1016/j.bbrc.2013.11.036
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.036
- Author:
- Yorgan, Timur; Rendenbach, Carsten; Jeschke, Anke; Amling, Michael; Cheah, Kathryn S.E.; Schinke, Thorsten
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 209-213
- ISSN:
- 0006-291X
- Subject:
- bone density; collagen; genes; growth plate; histology; homeostasis; mice; mineralization; mutation; osteoblasts; phenotype; rickets; transcription (genetics)
- Abstract:
- ... X-linked hypophosphatemic rickets (XLHR) is a severe disorder of phosphate homeostasis and skeletal mineralization caused by mutations of PHEX, encoding a bone-specific endopeptidase. Phex-deficient Hyp mice have been extensively studied to understand the molecular bases of XLHR, and here it was found that Fgf23, encoding a major phosphaturic hormone, was transcriptionally activated in bone-formin ...
- DOI:
- 10.1016/j.bbrc.2013.11.033
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.033
- Author:
- Park, Sun Hong; Roh, Eunmiri; Kim, Hyun Soo; Baek, Seung-Il; Choi, Nam Song; Kim, Narae; Hwang, Bang Yeon; Han, Sang-Bae; Kim, Youngsoo
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 183-188
- ISSN:
- 0006-291X
- Subject:
- anti-inflammatory activity; lipopolysaccharides; genes; chlorogenic acid; blood; protective effect; macrophages; volunteers; gene expression regulation; endotoxins; Escherichia coli; Toll-like receptors; humans; interleukins; isomers; mice; tumor necrosis factor-alpha; mortality; intravenous injection; nitric oxide; endotoxemia
- Abstract:
- ... Lonicerae flos extract (HS-23) is a clinical candidate currently undergoing Phase I trial in lipopolysaccharide (LPS)-injected healthy human volunteers, but its molecular basis remains to be defined. Here, we investigated protective effects of HS-23 or its major constituents on Escherichia coli LPS-induced septic mortality in mice. Intravenous treatment with HS-23 rescued LPS-intoxicated C57BL/6J ...
- DOI:
- 10.1016/j.bbrc.2013.11.045
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.045
- Author:
- Koh, Dong-In; Yoon, Jae-Hyeon; Kim, Min-Kyeong; An, Haemin; Kim, Min-Young; Hur, Man-Wook
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 177-182
- ISSN:
- 0006-291X
- Subject:
- B-lymphocytes; cell cycle; cell proliferation; chromatin; gene expression regulation; knockout mutants; oncogenes; phenotype; precipitin tests; repressor proteins; spleen; splenocytes; splenomegaly; transcription (genetics)
- Abstract:
- ... Kaiso was previously described as a methylated DNA-binding protein and a transcription repressor interacting with the corepressor protein complex NCoR. In the current study, we show that generation-3 Kaiso knockout mice show a phenotype of splenomegaly and large diffused germinal centers (GC). In the spleens of Kaiso knockout mice, Bcl6 (a transcriptional repressor that plays a critical role in GC ...
- DOI:
- 10.1016/j.bbrc.2013.11.046
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.046
- Author:
- Yuan, Feifei; Wang, Mengyao; Hao, Hongmei; Zhang, Yanfeng; Zhao, Huixian; Guo, Aiguang; Xu, Hong; Zhou, Xiaona; Xie, Chang Gen
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 202-208
- ISSN:
- 0006-291X
- Subject:
- Brassica oleracea; abscisic acid; drought; gene expression; signal transduction; stomata
- Abstract:
- ... ABI1 (ABA Insensitive 1) is an important component of the core regulatory network in early ABA (Abscisic acid) signaling. Here, we investigated the functions of an ABI1 ortholog in Brassica oleracea (BolABI1). The expression of BolABI1 was dramatically induced by drought, and constitutive expression of BolABI1 confers ABA insensitivity upon the wild-type. Subcellular localization and phosphatase a ...
- DOI:
- 10.1016/j.bbrc.2013.11.035
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.035
- Author:
- Kaneta, Yasuyuki; Ullrich, Axel
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 139-146
- ISSN:
- 0006-291X
- Subject:
- antineoplastic agents; carcinoma; cell death; centrosomes; chromosomes; cytokinesis; epithelium; image analysis; kidney neoplasms; kidneys; mitosis; neoplasm cells; phenotype; small interfering RNA
- Abstract:
- ... NEK9 is known to play a role in spindle assembly and in the control of centrosome separation, but the consequences of NEK9 targeting in cancer cells remain to be elucidated. In this study, we used siRNA to investigate the consequences of targeting NEK9 in glioblastoma and kidney cancer cells as a first step in assessing its potential as an anti-cancer therapeutic target. Live cell imaging revealed ...
- DOI:
- 10.1016/j.bbrc.2013.04.105
-
http://dx.doi.org/10.1016/j.bbrc.2013.04.105
- Author:
- Zhang, Gaoyang; Qi, Jianmin; Xu, Jiantang; Niu, Xiaoping; Zhang, Yujia; Tao, Aifen; Zhang, Liwu; Fang, Pingping; Lin, LiHui
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 153-158
- ISSN:
- 0006-291X
- Subject:
- Corchorus capsularis; Southern blotting; bioinformatics; biosynthesis; cellulose; complementary DNA; fiber quality; gene overexpression; genes; jute; lignin; quantitative polymerase chain reaction
- Abstract:
- ... In this study, the full-length cDNA of the UDP-glucose pyrophosphorylase gene was isolated from jute by homologous cloning (primers were designed according to the sequence of UGPase gene of other plants) and modified RACE techniques; the cloned gene was designated CcUGPase. Using bioinformatic analysis, the gene was identified as a member of the UGPase gene family. Real-time PCR analysis revealed ...
- DOI:
- 10.1016/j.bbrc.2013.11.053
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.053
- Author:
- Weber, Silvio; Wetzel, Sebastian; Prox, Johannes; Lehmann, Tobias; Schneppenheim, Janna; Donners, Marjo; Saftig, Paul
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 234-241
- ISSN:
- 0006-291X
- Subject:
- adults; bone marrow cells; bone marrow transplant; death; erythropoiesis; granulocyte colony-stimulating factor; immune system; mice; tissues
- Abstract:
- ... Adult hematopoiesis requires tightly regulated cell–cell interactions between hematopoietic cells and the bone marrow stromal microenvironment. We addressed the question if the ectodomain sheddase ADAM10 is essential to regulate adult hematopoiesis. Induced ADAM10 deletion in hematopoietic cells resulted in morphological and histological abnormalities that resemble an unclassified myeloproliferati ...
- DOI:
- 10.1016/j.bbrc.2013.11.020
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.020
- Author:
- Huang, Yen-Hua; Huang, Cheng-Yang
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 147-152
- ISSN:
- 0006-291X
- Subject:
- DNA replication; Western blotting; bacteria; gel chromatography; mutants; polyacrylamide gel electrophoresis; proteins; single-stranded DNA
- Abstract:
- ... DnaT and PriB are replication restart primosomal proteins required for re-initiating chromosomal DNA replication in bacteria. Although the interaction of DnaT with PriB has been proposed, which region of DnaT is involved in PriB binding and self-trimerization remains unknown. In this study, we identified the N-terminal domain in DnaT (aa 1–83) that is important in PriB binding and self-trimerizati ...
- DOI:
- 10.1016/j.bbrc.2013.11.069
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.069
- Author:
- Basílio, José; Hoeth, Martina; Holper-Schichl, Yvonne M.; Resch, Ulrike; Mayer, Herbert; Hofer-Warbinek, Renate; de Martin, Rainer
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 221-226
- ISSN:
- 0006-291X
- Subject:
- IKappaB kinase; angiogenesis; gene expression; gene expression regulation; growth factors; human umbilical vein endothelial cells; interleukin-1; metalloproteinases; promoter regions; reporter genes; signal transduction; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... The transcription factor Sox18 plays a role in angiogenesis, including lymphangiogenesis, where it is upregulated by growth factors and directs the expression of genes encoding, e.g., guidance molecules and a matrix metalloproteinase. Conversely, we found that in human umbilical vein endothelial cells (HUVEC) Sox18 is repressed by the pro-inflammatory mediator TNFα (as well as IL-1 and LPS). Since ...
- DOI:
- 10.1016/j.bbrc.2013.11.030
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.030
- Author:
- Lien, Huang-Wei; Yang, Chung-Hsiang; Cheng, Chia-Hsiung; Liao, Yung-Feng; Han, Yu-San; Huang, Chang-Jen
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 189-194
- ISSN:
- 0006-291X
- Subject:
- Danio rerio; gene expression; genes; zinc finger motif
- Abstract:
- ... Zebrafish synuclein-γ2 (sncgb) has been reported to be expressed specifically in the notochord. However, the mechanism by which the sncgb gene promoter is regulated has not been described. In this paper, we demonstrate that Zinc finger protein 219-like (ZNF219L) and sox9a are involved in the regulation of sncgb gene expression. Furthermore, we observed that over-expression of both ZNF219L and Sox9 ...
- DOI:
- 10.1016/j.bbrc.2013.11.042
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.042
- Author:
- Matsuura-Hachiya, Yuko; Arai, Koji Y.; Ozeki, Rieko; Kikuta, Ayako; Nishiyama, Toshio
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 38-43
- ISSN:
- 0006-291X
- Subject:
- angiotensin II; angiotensin-converting enzyme inhibitors; blood pressure; cell proliferation; hyperplasia; immunohistochemistry; inflammation; irradiation; maleates; mice; peptidyl-dipeptidase A; photoaging; receptors; tissue repair
- Abstract:
- ... Angiotensin-converting enzyme (ACE) activity and angiotensin II signaling regulate cell proliferation, differentiation, and tissue remodeling, as well as blood pressure, while in skin, angiotensin II signaling is involved in wound healing, inflammation, and pathological scar formation. Therefore, we hypothesized that angiotensin II is also involved in photoaging of skin. In this study, we examined ...
- DOI:
- 10.1016/j.bbrc.2013.10.162
-
http://dx.doi.org/10.1016/j.bbrc.2013.10.162
- Author:
- Park, Mi Hee; Kang, Dong Woo; Jung, Yunjin; Choi, Kang-Yell; Min, Do Sik
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 1-7
- ISSN:
- 0006-291X
- Subject:
- anti-inflammatory activity; anticarcinogenic activity; antioxidants; caffeic acid; carcinogenesis; enzyme activity; phospholipase D; propolis; transcription (genetics); transcription factor NF-kappa B; transcriptional activation
- Abstract:
- ... Upregulation of phospholipase D (PLD) is functionally linked with oncogenic signals and tumorigenesis. Caffeic acid phenethyl ester (CAPE) is an active compound of propolis extract that exhibits anti-proliferative, anti-inflammatory, anti-oxidant, and antineoplastic properties. In this study, we demonstrated that CAPE suppressed the expression of PLD1 at the transcriptional level via inhibition of ...
- DOI:
- 10.1016/j.bbrc.2013.09.105
-
http://dx.doi.org/10.1016/j.bbrc.2013.09.105
- Author:
- Oh, Sang-Keun; Yoon, Joonseon; Choi, Gyung Ja; Jang, Hyun A; Kwon, Suk-Yoon; Choi, Doil
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 116-121
- ISSN:
- 0006-291X
- Subject:
- Capsicum annuum; Phytophthora capsici; Phytophthora infestans; cell walls; drought; ethephon; gene expression regulation; genes; leaves; osmotic stress; pepper; peppers; plant development; plant pathogens; proteins; reverse transcriptase polymerase chain reaction; salt stress; salt tolerance; tomatoes
- Abstract:
- ... Homeodomain-leucine zipper (HD-Zip) family proteins are unique to plants, but little is known about their role in defense responses. CaHB1 is a nuclear factor in peppers, belonging to subfamily II of HD-Zip proteins. Here, we determined the role of CaHB1 in the defense response. CaHB1 expression was induced when pepper plants were challenged with Phytophthora capsici, a plant pathogen to which pep ...
- DOI:
- 10.1016/j.bbrc.2013.11.019
-
http://dx.doi.org/10.1016/j.bbrc.2013.11.019
- Author:
- Lu, Songhe; Xu, Dezhong
- Source:
- Biochemical and biophysical research communications 2013 v.442 pp. 8-15
- ISSN:
- 0006-291X
- Subject:
- Western blotting; adults; antagonists; autophagy; capsaicin; cold stress; heart; heat; hypertrophy; males; mice; oxidative stress; phosphorylation; proteins; temperature
- Abstract:
- ... Severe cold exposure and pressure overload are both known to prompt oxidative stress and pathological alterations in the heart although the interplay between the two remains elusive. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel activated in response to a variety of exogenous and endogenous physical and chemical stimuli including heat and capsaicin. The aim of t ...
- DOI:
- 10.1016/j.bbrc.2013.10.128
-
http://dx.doi.org/10.1016/j.bbrc.2013.10.128