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1. An oncolytic adenovirus enhances antiangiogenic and antitumoral effects of a replication-deficient adenovirus encoding endostatin by rescuing its selective replication in nasopharyngeal carcinoma cells

Author:
Liu, Ran-yi; Zhou, Ling; Zhang, Yan-ling; Huang, Bi-jun; Ke, Miao-la; Chen, Jie-min; Li, Li-xia; Fu, Xiang; Wu, Jiang-xue; Huang, Wenlin
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 171-176
ISSN:
0006-291X
Subject:
anticarcinogenic activity; carcinoma; cytotoxicity; gene therapy; human umbilical vein endothelial cells; humans; neoplasm cells; proteins
Abstract:
... A replication-deficient adenovirus (Ad) encoding secreted human endostatin (Ad-Endo) has been demonstrated to have promising antiangiogenic and antitumoral effects. The E1B55k-deleted Ad H101 can selectively lyse cancer cells. In this study, we explored the antitumor effects and cross-interactions of Ad-Endo and H101 on nasopharyngeal carcinoma (NPC). The results showed that H101 dramatically prom ...
DOI:
10.1016/j.bbrc.2013.11.047

2. Autophagy mediates anti-melanogenic activity of 3′-ODI in B16F1 melanoma cells

Author:
Kim, Eun Sung; Shin, Ji Hyun; Seok, Su Hyeon; Kim, Jun Bum; Chang, Huikyoung; Park, So Jung; Jo, Yoon Kyung; Choi, Eun Sun; Park, Jun-Seong; Yeom, Myeong Hun; Lim, Chol Seung; Cho, Dong-Hyung
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 165-170
ISSN:
0006-291X
Subject:
autophagy; melanin; melanocytes; melanogenesis; melanoma; mitochondria; peroxisomes; screening
Abstract:
... Autophagy is a cellular degradation process for cellular aggregates and unneeded cellular compartments including damaged mitochondria, ER, and peroxisomes. Melanosome is cellular organelle that is the cellular site of generation, storage and transports of melanin in melanocytes. Despite potential importance of autophagy, the role of autophagy in melanogenesis and melanosome autophagy are largely u ...
DOI:
10.1016/j.bbrc.2013.11.048

3. BolOST1, an ortholog of Open Stomata 1 with alternative splicing products in Brassica oleracea, positively modulates drought responses in plants

Author:
Wang, Mengyao; Yuan, Feifei; Hao, Hongmei; Zhang, Yanfeng; Zhao, Huixian; Guo, Aiguang; Hu, Jingjiang; Zhou, Xiaona; Xie, Chang Gen
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 214-220
ISSN:
0006-291X
Subject:
Arabidopsis; Brassica oleracea; abscisic acid; alternative splicing; cabbage; cytoplasm; drought; luciferase; phenotype; protein kinases; stomata; sucrose
Abstract:
... Open Stomata 1 (OST1), an ABA-activated sucrose non-fermenting 1 (SNF1)-related protein kinase, is critical for plant drought responses. We investigated the functions of two splicing isoforms of the OST1 ortholog in Brassica oleracea (BolOST1). BolOST1 expression was found to be dramatically induced by drought and high-salt stress, and the ectopic expression of BolOST1 restored the drought-sensiti ...
DOI:
10.1016/j.bbrc.2013.11.032

4. Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes

Author:
Okamoto, Mitsuhiro; Yamaoka, Mami; Takei, Masahiro; Ando, Tomomi; Taniguchi, Shigeki; Ishii, Isao; Tohya, Kazuo; Ishizaki, Toshimasa; Niki, Ichiro; Kimura, Toshihide
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 227-233
ISSN:
0006-291X
Subject:
DNA fragmentation; apoptosis; blood glucose; chronic exposure; cystathionine gamma-lyase; gene expression regulation; genes; glucose; high fat diet; hydrogen; hydrogen sulfide; insulin; islets of Langerhans; mice; middle-aged adults; noninsulin-dependent diabetes mellitus
Abstract:
... Chronic exposure to high glucose induces the expression of cystathionine gamma-lyase (CSE), a hydrogen sulfide-producing enzyme, in pancreatic beta-cells, thereby suppressing apoptosis. The aim of this study was to examine the effects of hydrogen sulfide on the onset and development of type 2 diabetes. Middle-aged (6-month-old) wild-type (WT) and CSE knockout (CSE-KO) mice were fed a high-fat diet ...
DOI:
10.1016/j.bbrc.2013.11.023

5. 27-Hydroxycholesterol induces recruitment of monocytic cells by enhancing CCL2 production

Author:
Kim, Sun-Mi; Lee, Sae-A; Kim, Bo-Young; Bae, Sun-Sik; Eo, Seong-Kug; Kim, Koanhoi
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 159-164
ISSN:
0006-291X
Subject:
T-lymphocytes; agonists; antibodies; arteries; atherosclerosis; chemokine CCL2; cholesterol; metabolites; mice; monocytes; secretion
Abstract:
... Deposition of lipids in the intima is followed by infiltration of inflammatory cells, like monocytic cells and T lymphocytes, in atherosclerosis. However, roles of lipids in the infiltration of the inflammatory cells are not clearly defined. We investigated the possible involvement of cholesterol or its catabolites in recruitment of monocytic cells. Consumption of a high cholesterol-diet resulted ...
DOI:
10.1016/j.bbrc.2013.11.052

6. Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway

Author:
Ohkuni, Aya; Ohno, Yusuke; Kihara, Akio
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 195-201
ISSN:
0006-291X
Subject:
acyl coenzyme A; bioactive properties; biochemical pathways; endoplasmic reticulum; eukaryotic cells; genes; humans; ligases; metabolism; mutants; sphingosine; yeasts
Abstract:
... Sphingosine 1-phosphate (S1P) plays important roles both as a bioactive lipid molecule and an intermediate of the sphingolipid-to-glycerophospholipid metabolic pathway. To identify human acyl-CoA synthetases (ACSs) involved in S1P metabolism, we cloned all 26 human ACS genes and examined their abilities to restore deficient sphingolipid-to-glycerophospholipid metabolism in a yeast mutant lacking t ...
DOI:
10.1016/j.bbrc.2013.11.036

7. Increased Col10a1 expression is not causative for the phenotype of Phex-deficient Hyp mice

Author:
Yorgan, Timur; Rendenbach, Carsten; Jeschke, Anke; Amling, Michael; Cheah, Kathryn S.E.; Schinke, Thorsten
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 209-213
ISSN:
0006-291X
Subject:
bone density; collagen; genes; growth plate; histology; homeostasis; mice; mineralization; mutation; osteoblasts; phenotype; rickets; transcription (genetics)
Abstract:
... X-linked hypophosphatemic rickets (XLHR) is a severe disorder of phosphate homeostasis and skeletal mineralization caused by mutations of PHEX, encoding a bone-specific endopeptidase. Phex-deficient Hyp mice have been extensively studied to understand the molecular bases of XLHR, and here it was found that Fgf23, encoding a major phosphaturic hormone, was transcriptionally activated in bone-formin ...
DOI:
10.1016/j.bbrc.2013.11.033

8. Inhibition of IRAK-4 activity for rescuing endotoxin LPS-induced septic mortality in mice by lonicerae flos extract

Author:
Park, Sun Hong; Roh, Eunmiri; Kim, Hyun Soo; Baek, Seung-Il; Choi, Nam Song; Kim, Narae; Hwang, Bang Yeon; Han, Sang-Bae; Kim, Youngsoo
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 183-188
ISSN:
0006-291X
Subject:
anti-inflammatory activity; lipopolysaccharides; genes; chlorogenic acid; blood; protective effect; macrophages; volunteers; gene expression regulation; endotoxins; Escherichia coli; Toll-like receptors; humans; interleukins; isomers; mice; tumor necrosis factor-alpha; mortality; intravenous injection; nitric oxide; endotoxemia
Abstract:
... Lonicerae flos extract (HS-23) is a clinical candidate currently undergoing Phase I trial in lipopolysaccharide (LPS)-injected healthy human volunteers, but its molecular basis remains to be defined. Here, we investigated protective effects of HS-23 or its major constituents on Escherichia coli LPS-induced septic mortality in mice. Intravenous treatment with HS-23 rescued LPS-intoxicated C57BL/6J ...
DOI:
10.1016/j.bbrc.2013.11.045

9. Kaiso is a key regulator of spleen germinal center formation by repressing Bcl6 expression in splenocytes

Author:
Koh, Dong-In; Yoon, Jae-Hyeon; Kim, Min-Kyeong; An, Haemin; Kim, Min-Young; Hur, Man-Wook
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 177-182
ISSN:
0006-291X
Subject:
B-lymphocytes; cell cycle; cell proliferation; chromatin; gene expression regulation; knockout mutants; oncogenes; phenotype; precipitin tests; repressor proteins; spleen; splenocytes; splenomegaly; transcription (genetics)
Abstract:
... Kaiso was previously described as a methylated DNA-binding protein and a transcription repressor interacting with the corepressor protein complex NCoR. In the current study, we show that generation-3 Kaiso knockout mice show a phenotype of splenomegaly and large diffused germinal centers (GC). In the spleens of Kaiso knockout mice, Bcl6 (a transcriptional repressor that plays a critical role in GC ...
DOI:
10.1016/j.bbrc.2013.11.046

10. Negative regulation of abscisic acid signaling by the Brassica oleracea ABI1 ortholog

Author:
Yuan, Feifei; Wang, Mengyao; Hao, Hongmei; Zhang, Yanfeng; Zhao, Huixian; Guo, Aiguang; Xu, Hong; Zhou, Xiaona; Xie, Chang Gen
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 202-208
ISSN:
0006-291X
Subject:
Brassica oleracea; abscisic acid; drought; gene expression; signal transduction; stomata
Abstract:
... ABI1 (ABA Insensitive 1) is an important component of the core regulatory network in early ABA (Abscisic acid) signaling. Here, we investigated the functions of an ABI1 ortholog in Brassica oleracea (BolABI1). The expression of BolABI1 was dramatically induced by drought, and constitutive expression of BolABI1 confers ABA insensitivity upon the wild-type. Subcellular localization and phosphatase a ...
DOI:
10.1016/j.bbrc.2013.11.035

11. NEK9 depletion induces catastrophic mitosis by impairment of mitotic checkpoint control and spindle dynamics

Author:
Kaneta, Yasuyuki; Ullrich, Axel
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 139-146
ISSN:
0006-291X
Subject:
antineoplastic agents; carcinoma; cell death; centrosomes; chromosomes; cytokinesis; epithelium; image analysis; kidney neoplasms; kidneys; mitosis; neoplasm cells; phenotype; small interfering RNA
Abstract:
... NEK9 is known to play a role in spindle assembly and in the control of centrosome separation, but the consequences of NEK9 targeting in cancer cells remain to be elucidated. In this study, we used siRNA to investigate the consequences of targeting NEK9 in glioblastoma and kidney cancer cells as a first step in assessing its potential as an anti-cancer therapeutic target. Live cell imaging revealed ...
DOI:
10.1016/j.bbrc.2013.04.105

12. Overexpression of UDP-glucose pyrophosphorylase gene could increase cellulose content in Jute (Corchorus capsularis L.)

Author:
Zhang, Gaoyang; Qi, Jianmin; Xu, Jiantang; Niu, Xiaoping; Zhang, Yujia; Tao, Aifen; Zhang, Liwu; Fang, Pingping; Lin, LiHui
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 153-158
ISSN:
0006-291X
Subject:
Corchorus capsularis; Southern blotting; bioinformatics; biosynthesis; cellulose; complementary DNA; fiber quality; gene overexpression; genes; jute; lignin; quantitative polymerase chain reaction
Abstract:
... In this study, the full-length cDNA of the UDP-glucose pyrophosphorylase gene was isolated from jute by homologous cloning (primers were designed according to the sequence of UGPase gene of other plants) and modified RACE techniques; the cloned gene was designated CcUGPase. Using bioinformatic analysis, the gene was identified as a member of the UGPase gene family. Real-time PCR analysis revealed ...
DOI:
10.1016/j.bbrc.2013.11.053

13. Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10)

Author:
Weber, Silvio; Wetzel, Sebastian; Prox, Johannes; Lehmann, Tobias; Schneppenheim, Janna; Donners, Marjo; Saftig, Paul
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 234-241
ISSN:
0006-291X
Subject:
adults; bone marrow cells; bone marrow transplant; death; erythropoiesis; granulocyte colony-stimulating factor; immune system; mice; tissues
Abstract:
... Adult hematopoiesis requires tightly regulated cell–cell interactions between hematopoietic cells and the bone marrow stromal microenvironment. We addressed the question if the ectodomain sheddase ADAM10 is essential to regulate adult hematopoiesis. Induced ADAM10 deletion in hematopoietic cells resulted in morphological and histological abnormalities that resemble an unclassified myeloproliferati ...
DOI:
10.1016/j.bbrc.2013.11.020

14. The N-terminal domain of DnaT, a primosomal DNA replication protein, is crucial for PriB binding and self-trimerization

Author:
Huang, Yen-Hua; Huang, Cheng-Yang
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 147-152
ISSN:
0006-291X
Subject:
DNA replication; Western blotting; bacteria; gel chromatography; mutants; polyacrylamide gel electrophoresis; proteins; single-stranded DNA
Abstract:
... DnaT and PriB are replication restart primosomal proteins required for re-initiating chromosomal DNA replication in bacteria. Although the interaction of DnaT with PriB has been proposed, which region of DnaT is involved in PriB binding and self-trimerization remains unknown. In this study, we identified the N-terminal domain in DnaT (aa 1–83) that is important in PriB binding and self-trimerizati ...
DOI:
10.1016/j.bbrc.2013.11.069

15. TNFα-induced down-regulation of Sox18 in endothelial cells is dependent on NF-κB

Author:
Basílio, José; Hoeth, Martina; Holper-Schichl, Yvonne M.; Resch, Ulrike; Mayer, Herbert; Hofer-Warbinek, Renate; de Martin, Rainer
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 221-226
ISSN:
0006-291X
Subject:
IKappaB kinase; angiogenesis; gene expression; gene expression regulation; growth factors; human umbilical vein endothelial cells; interleukin-1; metalloproteinases; promoter regions; reporter genes; signal transduction; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... The transcription factor Sox18 plays a role in angiogenesis, including lymphangiogenesis, where it is upregulated by growth factors and directs the expression of genes encoding, e.g., guidance molecules and a matrix metalloproteinase. Conversely, we found that in human umbilical vein endothelial cells (HUVEC) Sox18 is repressed by the pro-inflammatory mediator TNFα (as well as IL-1 and LPS). Since ...
DOI:
10.1016/j.bbrc.2013.11.030

16. Zinc finger protein 219-like (ZNF219L) and Sox9a regulate synuclein-γ2 (sncgb) expression in the developing notochord of zebrafish

Author:
Lien, Huang-Wei; Yang, Chung-Hsiang; Cheng, Chia-Hsiung; Liao, Yung-Feng; Han, Yu-San; Huang, Chang-Jen
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 189-194
ISSN:
0006-291X
Subject:
Danio rerio; gene expression; genes; zinc finger motif
Abstract:
... Zebrafish synuclein-γ2 (sncgb) has been reported to be expressed specifically in the notochord. However, the mechanism by which the sncgb gene promoter is regulated has not been described. In this paper, we demonstrate that Zinc finger protein 219-like (ZNF219L) and sox9a are involved in the regulation of sncgb gene expression. Furthermore, we observed that over-expression of both ZNF219L and Sox9 ...
DOI:
10.1016/j.bbrc.2013.11.042

17. Angiotensin-converting enzyme inhibitor (enalapril maleate) accelerates recovery of mouse skin from UVB-induced wrinkles

Author:
Matsuura-Hachiya, Yuko; Arai, Koji Y.; Ozeki, Rieko; Kikuta, Ayako; Nishiyama, Toshio
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 38-43
ISSN:
0006-291X
Subject:
angiotensin II; angiotensin-converting enzyme inhibitors; blood pressure; cell proliferation; hyperplasia; immunohistochemistry; inflammation; irradiation; maleates; mice; peptidyl-dipeptidase A; photoaging; receptors; tissue repair
Abstract:
... Angiotensin-converting enzyme (ACE) activity and angiotensin II signaling regulate cell proliferation, differentiation, and tissue remodeling, as well as blood pressure, while in skin, angiotensin II signaling is involved in wound healing, inflammation, and pathological scar formation. Therefore, we hypothesized that angiotensin II is also involved in photoaging of skin. In this study, we examined ...
DOI:
10.1016/j.bbrc.2013.10.162

18. Caffeic acid phenethyl ester downregulates phospholipase D1 via direct binding and inhibition of NFκB transactivation

Author:
Park, Mi Hee; Kang, Dong Woo; Jung, Yunjin; Choi, Kang-Yell; Min, Do Sik
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 1-7
ISSN:
0006-291X
Subject:
anti-inflammatory activity; anticarcinogenic activity; antioxidants; caffeic acid; carcinogenesis; enzyme activity; phospholipase D; propolis; transcription (genetics); transcription factor NF-kappa B; transcriptional activation
Abstract:
... Upregulation of phospholipase D (PLD) is functionally linked with oncogenic signals and tumorigenesis. Caffeic acid phenethyl ester (CAPE) is an active compound of propolis extract that exhibits anti-proliferative, anti-inflammatory, anti-oxidant, and antineoplastic properties. In this study, we demonstrated that CAPE suppressed the expression of PLD1 at the transcriptional level via inhibition of ...
DOI:
10.1016/j.bbrc.2013.09.105

19. Capsicum annuum homeobox 1 (CaHB1) is a nuclear factor that has roles in plant development, salt tolerance, and pathogen defense

Author:
Oh, Sang-Keun; Yoon, Joonseon; Choi, Gyung Ja; Jang, Hyun A; Kwon, Suk-Yoon; Choi, Doil
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 116-121
ISSN:
0006-291X
Subject:
Capsicum annuum; Phytophthora capsici; Phytophthora infestans; cell walls; drought; ethephon; gene expression regulation; genes; leaves; osmotic stress; pepper; peppers; plant development; plant pathogens; proteins; reverse transcriptase polymerase chain reaction; salt stress; salt tolerance; tomatoes
Abstract:
... Homeodomain-leucine zipper (HD-Zip) family proteins are unique to plants, but little is known about their role in defense responses. CaHB1 is a nuclear factor in peppers, belonging to subfamily II of HD-Zip proteins. Here, we determined the role of CaHB1 in the defense response. CaHB1 expression was induced when pepper plants were challenged with Phytophthora capsici, a plant pathogen to which pep ...
DOI:
10.1016/j.bbrc.2013.11.019

20. Cold stress accentuates pressure overload-induced cardiac hypertrophy and contractile dysfunction: Role of TRPV1/AMPK-mediated autophagy

Author:
Lu, Songhe; Xu, Dezhong
Source:
Biochemical and biophysical research communications 2013 v.442 pp. 8-15
ISSN:
0006-291X
Subject:
Western blotting; adults; antagonists; autophagy; capsaicin; cold stress; heart; heat; hypertrophy; males; mice; oxidative stress; phosphorylation; proteins; temperature
Abstract:
... Severe cold exposure and pressure overload are both known to prompt oxidative stress and pathological alterations in the heart although the interplay between the two remains elusive. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel activated in response to a variety of exogenous and endogenous physical and chemical stimuli including heat and capsaicin. The aim of t ...
DOI:
10.1016/j.bbrc.2013.10.128